癌化

In summary, MPC is an aggressive subtype of metaplastic carcinoma with a worse clinical outcome than invasive ductal carcinoma.

MPC是一种侵袭性的乳腺化生性癌，其预后比浸润性导管癌更差。

Methods The expression of P73 in 92 cases of colorectal carcinoma tissue, 10 cases of colorectal polypous adenoma tissues, 34 cases of lymph node metastasis, 16 cases of liver metastasis, and 10 cases of normal colorectal tissues were measured by PV immunohistochemical approach.

选取92例大肠癌组织标本，腺瘤10例，淋巴结转移灶34例，肝转移灶16例，癌旁正常组织10例，通过免疫组化PV-9000通用型二步法检测P73在上述标本中的表达，分析P73在原发灶，转移灶，癌旁正常组织中的表达情况，与大肠癌临床病理参数的关系。

To investigate the possibility of such a transition, we studied 17 cases of MGA or atypical MGA some of which had given rise to carcinoma in situ and/or invasive ductal carcinoma using the reticulin stain, immunohistochemistry (S-100, p63, Ki-67, and p53), and a molecular approach involving microdissection and high-resolution comparative genomic hybridization and MYC chromogenic in situ hybridization.

为了研究这种转变的可能性，我们分析了17例典型或非典型的MGA，其中一些已经发展成为原位癌和/或浸润性导管癌，所用的方法是网状染色、免疫组化（S-100， p63， Ki-67， and p53）和分子技术，分子技术包括显微切割和高分辨率比较基因组杂交及MYC显色的原位杂交。

It can inhibit the transmethylation activity through conjugating with DNMT1 and forming a covalent compound when conjugated with replicating DNA molecule. Then the formation of hypomethylated daughter chain makes the demethylation function ture.

体外实验已经证实DNA甲基转移酶抑制剂5Aza-dc通过去甲基化作用可使多种含有CpG岛的高甲基化抑癌基因重新表达，从而恢复抑癌功能，这一研究结果对于肿瘤的基因治疗提供了一个新的思路。

It was noted that the protein bands between 23 ku and 40 ku which bound to ulex europaeus agglutinin and lens culinaris agglutinin reduced significantly until 20 weeks when the liver mass formed, but the band at 80 ku became denser week after week during the course of rat hepatocarcinogenesis induced by N nitrosodiethylamine.

在化学诱发的大鼠肝癌过程中，分子质量在 2 3ku到 4 0ku范围内与荆豆凝集素及扁豆凝集素结合的岩藻糖糖基化蛋白显著减少，诱癌至 17～ 2 0周这些条带重新恢复，而分子质量为 80ku的条带却在诱癌过程中逐周增加。

Surveillance: annual ophthalmologic examination; at least annual examination of the skin for solar keratoses, basal cell carcinoma, squamous cell carcinoma; annual pulmonary function testing in those over age 20 years; routine history for symptoms of colitis (e.g., cramping, increased mucus in the stool, rectal bleeding).

监视：每年一次眼科检查；至少每年检查一次皮肤，视有否日光角化病、基底细胞癌、鳞状细胞癌；对20岁以上的患者每年检测一次肺功能；例行进行结肠炎病史调查（如痉挛、凳子上增加的粘液、直肠出血）。

Methods: The expression of PCNA and p53 protein were examined by immunohistochemistry in tumour tissue and adjacent tissue of 78 cases of colorectal cancer and in 12 normal colonic mucosae.

用免疫组化染色方法对78例大肠癌标本的癌组织、癌旁粘膜及12例正常大肠粘膜进行p53蛋白、增殖细胞核抗原检测，并进行随访。

Results In situ hybridization of the three genes and immunohistochemistry showed that positive products were all located in the cytoplasms and nuclei.

应用原位杂交法检测47例食管鳞状细胞癌及其癌旁、上切缘中3种基因的mRNA、免疫组化SABC法检测蛋白表达水平。

Methods 68 specimens of mammary exsected due to breast cancer were tested by method of immunohistochemistry,pathology and molecularbiology to detect the expression of PCNA,P53,C-erbB-2 in tumor and around tumor.

对68例乳腺癌全乳腺切除标本采用常规病理、免疫组化及分子生物学方法，检测癌和癌旁不同范围组织增殖细胞核抗原（proliferation cell nuclear antigen，PCNA）、P53、C-erbB-2等表达情况。

Methods 40 cases of PTC with LNM, 44 papillary thyroid carcinomas without LNM, 30 thyroid adenoma and 30 normal thyroids were studied by ABC immunohistochemical method.

应用免疫组化ABC 法对40 例有颈淋巴结转移的甲状腺乳头状癌，44 例无颈淋巴结转移的甲状腺乳头状癌，30 例甲状腺瘤和30 例正常甲状腺组织进行了C D44v6 ，，EGFR 检测。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。