癌化

AIM: To investigate the expressions of methylthioadenosine phosphorylase and ornithine decarboxylase in human ovarian cancer.

目的： 研究甲硫腺苷磷酸化酶基因和鸟氨酸脱羧酶在卵巢癌中的表达，探讨两者与卵巢癌发病机制的关系。

Study on detecting hypermethylation of the related genes in pancreastic juice to diagnose pancreatic diseases INTRODUCTION Pancreatic cancer is still one of the most common malignant cancers to human, and it is the fourth and sixth cause of death in American and Europe, and also the fifth cause of death in Japan, in our country is the tenth cause of death.

胰液中相关基因高甲基化检测在胰腺疾病诊断中的应用研究前言胰腺癌是二十一世纪人类面临的高度恶性肿瘤之一，在北美洲和欧洲分别占癌症死亡原因的第四位和第六位，在日本占第五位，在我国为前10位。90％的胰腺癌患者在诊断后一年内死亡，诊断后平均生存时间为三个月，适合手术者低于15％，手术平均切除病例的术后5年生存率低于4％。

Objective To study the thymidine phosphorylase expression in different types of cancer and its correlation with tumor microvessel density.

目的 研究胸苷磷酸化酶在不同种类癌组织中的表达，探讨TP与癌组织血管生成的关系。

The number of positive cells of PCNA in 63 cases of tissue was represented...

结果 ：下咽癌组PCNA增殖指数为(71 。4 8± 1 1 。1 4 )%，对照组为(2 1 。1 3±1 2 。0 7)%，其差异有显著性意义(P 。0 5 )；PCNA增殖指数与癌的临床分期、组织分化程度及预后相关，而与是否有颈淋巴结转移和肿瘤发生部位无明显关系，且免疫组化和原位杂交两种检测结果相一致(符合率为 85 。7%)。

METHODS: Semiquantitative RTPCR assay was used to detect the expression of MICA mRNA and SP immunohistochemistry to detect the expression of MICA protein in 41 patients with gastric cancer. Spearman rank correlation was used to analyze the correlation between them.

采用RTPCR技术检测41例高原地区胃癌组织和相应的癌旁粘膜组织中MICA mRNA表达，采用免疫组化SP法检测MICA蛋白在胃癌和癌旁组织中的表达，Spearman相关关系检验分析它们之间的相关性。

Part I Role of glycogen synthase kinase 3 in squamous differentiation induced by cigarette smoke in porcine airway epithelial cell Squamous differentiation of airway epithelium induced by diverse stimuli, such as cigarette smoke, has been thought to be an adaptive response to chronic injury as well as a precancerous lesion of lung squamous carcinoma.

第一部分糖原合成酶激酶3在吸烟诱导的猪气道上皮细胞鳞状分化中的作用研究气道上皮的鳞状细胞化生常见于慢性支气管炎症、致癌剂刺激等，一般被认为是对慢性损伤的一种适应性反应，也是肺鳞癌的癌前病变，其分子机制尚未完全阐明。

Objective To investigate the expression and its significance of P16, Cyclin D1 and pRb in human outrageous squamous cell carcinoma and the relationship between the throe proteins, and to investigate the relationship between the methylation of p16 gene and the development of the CSCC.

目的 探讨P16、Cyclin D1和pRb蛋白在皮肤鳞状细胞癌中的表达及他们的相互关系和意义；研究p16基因甲基化是否与原发性皮肤鳞癌的发生有关。

Methods The expression of CD147, MMP-9 and p-ERK was immunohistochemically examined in 96 cases of IDC of breast, 34 cases of ductal carcinoma in situ and 10 cases of breast adenosis.

应用免疫组化Envision二步法检测96例乳腺浸润性导管癌(invasive ductal carcinoma， IDC)、34例导管内癌(ductal carcinoma in situ， DCIS)及10例乳腺腺病中CD147、MMP-9及p-ERK蛋白的表达，并分析其与临床病理参数的相关性。

Results: CK18 was not detected in normal and abnormal oral tissue sections. But in normal nonkeratinized mucosa, CK19 was detected in the basal cell layer dispersively. In epithelial dysplasia, CK19 was detected in the suprabasal cell layer and the number of CK19-positive cell layers was correlated with the dysplasia degree of epithelia. Furthermore, CK19 was detected in oral squamous cell carcinoma, especially in the poor-differentiated cancer cells.

结果：正常和异常的口腔粘膜均未检测到CK18；CK19可表达于正常非角化上皮的基底层细胞、异常增生上皮的基底上层细胞及口腔鳞状细胞癌中，阳性细胞数与上皮的异常增生程度及鳞癌的分化程度相关。

Methods: The gastrin and PCNA expression in 48 cases of colorectal cancer tissue and cancer-adjacent mucosa were detected with immunohistochemistry techniques.

采用免疫组化法检测48例大肠癌患者癌组织及癌旁粘膜胃泌素和PCNA的表达。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。