癌化

Objective:To investigate the relationship between p21WAF1 gene expression and histone acetylation in gastric cancer.

简介： 目的：探讨胃癌组织p21WAF1基因表达与组蛋白乙酰化的关系。方法：利用RT-PCR对53例原发性胃癌的癌组织、癌旁组织和正常胃黏膜的p21WAF1 mRNA表达进行分析；同时对其中p21WAF1 mRNA表达失活或表。。。

AIM and METHODS : Immunohistochemical technique in combination with a computer assisted TV-image analysis system were used to measure the expression level of c-erbB-2 and bcl-2 proteins in 37 cases of lung squamous carcinoma and 48 cases of lung adenocarcinoma identified pathologically. The expression of c-erbB-2 and bcl-2 genetic proteins in lung carcinoma and some image signs of invasiveness of lung carcinoma were analysed correlatively.

摘 要 目的和方法：利用免疫组化技术LSAB法和计算机图像分析系统的结合，测定经手术病理证实之37例肺鳞癌及48例肺腺癌组织中c- erbB -2及 bcl -2基因蛋白的表达水平，分析其表达或共表达与反映肺癌侵袭力的影像征象的关系。

METHODS: COX 2 and VEGF protein expressions were detected by immunohistochemical staining in 15 seborrheic keratosis, 15 Bowen s disease, 20 basal cell epithelioma, 20 squamous cell carcinoma and 5 normal skin tissues.

免疫组织化学法检测脂溢性角化病15例，皮肤原位癌15例，基底细胞上皮瘤20例，鳞癌20例及正常组织5例COX 2和VEGF的表达。

Clinical manifestations are soreness on epigastric region, decreased appetite, distention after meal and eructation. It belongs to "epigastric pain" and "Stomach Pi syndrome" in TCM with characteristics of repetition and pertinacity. In 1978, WHO listed chronic atrophic gastritis as precancerous lesions of gastric cancer because its complications of intestinal metaplasia and dysplasia are closely related to gastric cancer. This has been a research focus in clinical practice and pathology for years.

临床主要表现为上腹隐痛、食欲减退、食后饱胀、嗳气等，属中医学"胃脘痛"、"胃痞"等范畴，具有反覆发作、迁延难愈的特性。1978年WHO将慢性萎缩性胃炎列为胃癌的癌前状态，而在其基础上伴发的肠上皮化生(Intestinal metaplasia，IM)和域异型增生(DYSplasia， DYS)，则与胃癌的发生关系密切，被视为癌前病变(Precacerous lesions Of gastric cancer， PLGC)多年来始终是临床及病理学研究的重点。

Objective To evaluate vascular skeletonization of hepatic hilum in the treatment of T3, T4 gallbladder carcinoma.

目的 探讨肝门血管骨骼化胆囊癌根治术或扩大根治术对T3，T4胆囊癌的治疗价值。

Strumal carcinoid of ovary may be derived from multidirectional differentiations of endodermal origin with low potential malignancy.

卵巢甲状腺肿类癌起源于内胚层，低度恶性，诊断主要依赖病理和免疫组化，需要与颗粒细胞瘤、卵巢恶性甲状腺肿、卵巢类癌等鉴别。

Objective To investigate the aberrantly methylated status in human thyroid cancer.

中文摘要：目的：筛选、克隆甲状腺癌组织与癌旁甲状腺组织的甲基化差异片断。

Ethylation specific PCR analysis also revealed that the BLU promoter was highlymethylated in 74％(17 of 23) of primary tumors where the gene was downregulated,whereas only 2 of 9 non-neoplastic nasopharyngeal epithelia exhibitedhypermethylation in the BLU promoter region.

SP分析的结果表明，在23例表达下调的鼻咽癌组织中，17例(74％，17／23)标本的BLU基因发生了异常甲基化，而9例非癌对照中仅有2例甲基化，说明启动子甲基化在BLU基因的转录失活中具有重要作用。

Erve growth factor can combine with its" receptor (one of tyrosine protein kinase receptor coded by proto - oncogene tyrosine kinase, TrkA), Causing the molecule of receptors to gather on the cell surface, and the tyrosine protein in cytoplasmic domain may be activated, three tyrosine base in the kinase domain of its" receptor and two tyrosine base at other domain be phosphated, thus, phosphated tyrosine receptor kinase became the bracket which absorb all kinds of connective proteins and kinases.

GF与其酪氨酸受体激酶受体(由原癌基因trk编码的一种酪氨酸蛋白激酶受体，TrkA)相结合，引起受体分子在细胞表面发生二聚体化，然后受体细胞内结构上酪氨酸活性被激活，使受体自身结构中位于激酶结构域的三个酪氨酸残基及在此结构域外的两个酪氨酸残基发生自身磷酸化，这样，磷酸化的酪氨酸受体激酶A便成为吸收各种连接蛋白质和酶的支架。

Theoretically, re-expression of tumor suppressor genes by demethylating agents may contribute to inhibiting the development of tumor. It has been suggested that DNA hypermethylation results in resistance to chemotherapy and consequently reduces the efficacy of chemotherapeutic treatment.

由于高度甲基化而暂停表达的抑癌基因，如果能应用去甲基化制剂逆转甲基化的异常状态，使之重获表达，理论上即可发挥其抑制肿瘤细胞生长的功能。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。