癌化

Objective: To investigate the role of p16 gene aberrant methylation in the malignant progression of human bladder cancer.

目的：研究膀胱移行细胞癌中p16基因甲基化失活及其在肿瘤发生中的作用。

Methods Ecadherin and PCNA in 59 cases of pancreatic adenocarcinoma was studied by immunohistochemistry.

应用免疫组化方法对59例胰腺癌组织的Ecadherin、PCNA进行检测。

Objective:To study the relationship between CXCL12/CXCR4 expression and the neural invasion of salivary adenoid cystic carcinoma.

目的：探讨趋化因子CXCL12及其受体CXCR4与涎腺腺样囊性癌嗜神经侵袭之间的关系。

Inhibiting gene abnomal methylic P16 become higher with cervical neoplasia,it is a early event in the process of cervical cancer.So it has important clinical significance in early diagnosis of cervical cancer.

抑癌基因P16异常甲基化随宫颈瘤样病变的加重而阳性率增高，P16异常甲基化是宫颈发生的过程中的早期事件，对于宫颈癌的早期诊断具有重要意义。

P16 gene is composed of two intervening sequences and three exons , and encodes p16 protein , which is the inhibiter of CDK4 and CDK6 . They can together prevent phosphorylation deactivation of pRB , and make the cell cycle blocked in G1 stage. P16 gene promoter region has a great of CpG islands , which can be methylated when some adverse factor appears , and so the genetic transcription of p16 can be inhibited , which leads to gene silencing, cell paraplasm, and tumor generate.

抑癌基因p16编码蛋白P16 ，是细胞周期蛋白CDK4和CDK6抑制剂，它阻止pRB磷酸化失活，使细胞周期阻滞于G1期。P16基因启动子区域富含CpG岛，当受到各种有害因素影响时，容易发生甲基化，从而抑制P16基因转录，导致基因沉默，细胞异常增生，导致肿瘤的发生[5]。

Hyperkeratotic Porokeratosis of Mibelli in a Patient with Hepatocellular Cell Carcinoma, Hepatitis B and Recurrent Hypoglycemia

篇名 在肝细胞癌，B型肝炎和反覆性低血糖病人身上的过度角化米贝利汗孔角化症

All the normal cervical epithelial samples (10/10) and 90%(36/40) of cervicalcarcinomas had the positive lanes by using the unmethylated

然而，12例无基因甲基化的癌标本也有FHIT蛋白的异常表达，提示基因甲基化可以导致基因的失活，但不是基因失

ResultsThe rate of methylation of p15 gene was detected 37.8% in the tumor tissues and naive in the normal uro...

结论p15基因在膀胱移行细胞癌组织中的甲基化率较高，其异常高甲基化在膀胱癌的发生、发展中具有重要作用。

Results: The positive detection ratio of IHC and nested PCR were 64.2% and 81.1%, respectively. It was showed that the positive detection ratio of nested PCR was significantly higher than that of IHC (P.01). The nested PCR assay had advantages over IHC on sensitivity, specificity, Youden's index, positive predictive value and negative predictive value.

结果：免疫组化检测和巢式PCR检测的阳性检出率分别为64.2%和81.1%，巢式PCR技术检测肾癌组织支原体在灵敏度、特异度、约登指数、阳性预测值和阴性预测值方面均优于免疫组化技术。

It is possile to induce re-expression of a hypermethylated and silenced tumor suppressor gene by intervening in the DNA methylation and in histone deacetylation. It is worthful to deepen the study on the area of"transcriptional path"for prevention and cure of leukemia.

干扰DNA甲基化和组蛋白去乙酰化，以恢复抑癌基因的重新表达是可能的，通过这种&转录途径&防治白血病是值得深入探讨的研究领域。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。