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Objective: To investigate the best surgical method of thyroid adenoma.

目的:探讨甲状腺腺瘤的最佳手术方式。

Objective: To summarize the experience of diagnosis and treatment of parathyroid adenoma.

中文摘要:目的:总结甲状旁腺腺瘤的诊断治疗经验及技术。

Objective:To summarize the character of adenoma of stomach.

目的:总结胃腺瘤的特点。

Objective: To provide anatomic data for imaging diagnosis of pituitary adenoma.

目的:为垂体腺瘤的影像诊断提供解剖学基础。

Objective To evaluate the diagnosis and operational styles of thyroid adenoma.

目的:探讨甲状腺腺瘤的诊断方法及手术方式。

First, the individuals who would be most likely to benefit need to be identified, writes editorialist Sanford Markowitz, MD, PhD, from Case Western Reserve University, in Cleveland, Ohio. Then, it needs to be shown that certain persons reproducibly demonstrate high COX-2 expression in independent adenomas or cancers, because of genetic predisposition or environmental exposures. And third, the work of Dr. Chan and colleagues needs to be extended by demonstrating that prevention of colon adenomas by aspirin or COX-2 inhibitors also involves blocking the development of the highest COX-2–expressing lesions, he says.

俄亥俄州克里夫兰Case Western Reserve大学的Case Western Reserve医师表示,首先,必须要拿找出最能受益的一群病患;接著,必须要能证实部分病患的独立腺瘤或癌症,因为基因及环境的影响,会一再地是高度表现COX-2的;第三,Chan医师与其同事的研究,需要透过aspirin或是COX-2抑制剂可以预防大肠腺瘤的作用,也牵涉到阻断COX-2表现病灶的生成。

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子,CD83分子表达明显高于国内报道;肝癌患者DC培养上清中TNF水平高于健康人,提示肝癌患者DC仍具一定的抗原呈递能力,适当调控可使其行使APC功能,以期在肝癌个体化疫苗中发挥作用;DC负载肝癌可溶性抗原后,抗原呈递能力降低,BCG HSP70可促进DC成熟,增加其抗原呈递能力,预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子;肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞,活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主,同时分泌较高水平Th1型细胞因子IL-12和TNF,并抑制4种肝癌细胞生长;冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤,提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用;用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽,在体外诱导肝癌特异性淋巴细胞,活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF,并具较强杀伤活性,此CTL同时具备NK细胞特征;DC对肿瘤细胞的抑制作用可能是通过吞噬实现的,Fas-L在DC抑制中也起一定作用;DC对人肝癌裸鼠皮下移植瘤的抑制率为97%;在肝癌DC疫苗的作用中,至少联合3种以上机制,即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

In order to discover acid-tolerant Rhizobium meliloti that can nodulate alfalfa high-effectively on acidic soil, researches were explored to isolate rhizobia from alfalfa nodules on acidic soil (pH5.2), methods based on the thesis of adaptive acid-tolerance response of the Rhizobia were adopted, six strains were isolated, which could grow on solid medium with pH4.8 steadily. In addition, the nodulation characteristics, growth curves and mean generation time under different acidity of the strains were examined.

为获得能够使紫花苜蓿在酸性土壤中高效结瘤的耐酸根瘤菌,该研究从酸性土(pH5.2)上生长的紫花苜蓿根瘤中分离到若干菌株,利用根瘤菌对酸的适应性耐受反应筛选到六株能够在pH4.8的固体培养基上稳定生长的菌株,并检测了这六株菌的结瘤特征、不同酸度下的生长曲线和平均代时。

The giant cell tumor of spine has its own specific radiographic feature. There is some recurrence in simple curettage of tumor lesion. The thoroughly en bloc resection of tumor or spondylectomy, bone fusion and strong inter fixation are the key points for successful surgical treatment, the clinic behavior of bone giant cell tumor is somewhat unpredictable.

脊柱骨巨细胞瘤之影像学表现有其特殊性;肿瘤彻底切除、植骨融合及坚强的内固定是手术成功的关键,单纯肿瘤病灶切除术存在一定的复发率;骨巨细胞瘤的临床行为具有一定的不可测性。

Statistical data of VEGF grading scores showed that its expression was not significantly related to the size and location of glioma, sex, and age of patients, but closely related to the glioma gradings. The expression of TF was positively correlated with that of VEGF, suggesting that TF might participate in the anigogenesis of gliomas, and provide proper environment for the growth of gliomas through its coagulant effect.

根据VEGF分级计数统计学分析,显示VEGF表达与肿瘤的大小、部位及患者性别、发病年龄等临床因素无显著相关性,而与肿瘤的组织学分级密切相关。3、胶质细胞瘤中TF与VEGF的表达正相关,TF可能参与了肿瘤血管的生成过程,并通过其促凝血活性作用为胶质瘤的生长创造适宜的内环境。

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