瘤

Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果：酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间，给药剂量为80μg／kg／d时疗效最显著，达到69.24％，在20μg／kg／d-80μg／kg／d剂量范围内生命延长率为50-70％，给药剂量与荷瘤鼠生存时间呈现一定量效关系；酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长，给药剂量为160μg／kg／d时疗效最显著，抑制率为44.03％，并且在40-320μg／kg／d剂量范围内抑制率为25-50％，给药剂量与肿瘤抑制率呈现一定量效关系；酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用，在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显，其中浓度为100μg／ml时抑制率达19.36％；酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤：体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与效应细胞对照组相比有显著性差异(P＜0.05)杀伤率分别达到35.58％、61.2％；体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P 。05)，杀伤率分别达到21.39%、47.63%；裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P.05)，最高杀伤率分别达到32.86%、73.07%；酪丝亮肤能增强单核巨噬细胞系统的吞噬功能，吞噬指数与生理盐水组比较有显著性差异(P.05)；酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与效应细胞对照组相比有显著性差异(P.05)；酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与生理盐水对照组相比有显著性差异(P.05)；酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO，IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰，酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能，而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

Results:Among the 123 cases of patients with nipple discarge, 63 cases were diagnosed as mammary duct inflammation, 30 cases were diagnosed as mammary duct ectasia, 26 cases were related single or multiple papilloma, early cancer were 3 case...

结果：123例有乳头溢液的患者中，乳腺导管炎63例，乳腺导管扩张症30例，乳腺导管内乳头状瘤或瘤病26例，导管内癌3例，乳头皮脂腺囊肿并感染1例。

FDS was successfully inserted into 204 orifices(97.0%).Early breast cancer was found in 9 cases(4.5%), papilloma and papillomatosis in 66 cases(33.0%),ductal ectasia and/or chronic inflammation in 96 cases(48.0%);"normal duct" in 29 cases(14.5%).

本组发现早期乳腺癌9例（4.5%），乳头状瘤63例（31.5%），乳头状瘤病3例（1.5%），导管扩张或伴炎症96例（48.0%），&正常&导管29例（14.5%）。

Embryonal carcinoma and neuroblastoma are both formed during embryonal development, retinoic acid can induce them to differentiate into neurons.

胚胎瘤和神经母细胞瘤都是胚胎发育期间形成的肿瘤，维甲酸可以诱导这两种肿瘤细胞向神经元方向分化，在研究神经元分化机理时作为细胞模型得以广泛应用。

Application of pancreaticoduodenectomy for potentially malignant endocrinal tumor in pancreatic head, the value of surgical procedure in patient asymptomatic primary hyperparathyroidism or in patient with gastrinoma with MEN-1 , etc.

比较有代表性的包括低危组的分化型甲状腺癌患者是否应作甲状腺全切除、胰头部恶性倾向的内分泌肿瘤是否需作胰头十二指肠切除、无症状甲状旁腺腺瘤患者应手术还是随访观察、合并MEN-1的胃泌素瘤患者是选择手术切除抑或药物控制等等。

Objective To study the diagnostic and therapeutiic features of prolacfinoma in methods 23 male Patients with prolactinoma patienta in clinical manifestation, pathologic, endocrinological, radiographic andtherapeutic features.

目的 分析总结男性垂体泌乳素腺瘤的诊断和治疗特点：方法对10年间23例男性垂体泌乳素腺瘤患者的临床表现和肿瘤的病理学、内分泌学、影像学及治疗特点进行分析。

Objectives To describe the clinical characteristics and the role of chemotherapy in endodermal sinus tumor of the vagina.

目的探讨阴道内胚窦瘤的临床特点及化疗效果。方法对2例阴道内胚窦瘤进行临床报告及分析。

The endodermal sinus tumor of the ovary stands first in the incidence of malignant germ cell tumors of the ovary in China.

卵巢内胚窦瘤的发生率在中国各类型卵巢恶性生殖细胞瘤中位居首位。

Results In four cases, one was lipochoristoma of the acoustic nerve, two were low-grade papillary adenocarcinoma of endolymphatic sac origin, and another one was juxtaoral organ of Chievitz presenting clinically as a tumor mass.

结果 1例为听神经脂肪瘤样迷离瘤，2例为内耳内淋巴囊来源的低级别乳头状腺癌，1例为类似肿瘤病变的Chievitz口旁器官。

Results All patients were for their epilepsy and hypophrenia,two patients had multiple angimyolipomain their one kidney,one patient had a tumor under endyma.

结果 5例患者均以智力低下、癫痫就诊，2例出现肾错构瘤，1例见巨细胞星形细胞瘤。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。