瘤

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

Results About 39 cases were diagnosed as benign tumors,majority of which were demoid cysts.The another one case was borderline mucinous cystadenoma.Eight cases were diagnosed by ultrasound examination during the first trimester(53.33 %),4 had complication to do emergency operations,3 were caused by torsion,one by rupure.Serum samples for CA125 estimation were obtained from 3 before operations.AS a result,2 cases were elevated,one of which was borderline mucinoers cystadenoma.38 cases were full-term birth.

结果 妊娠期良性肿瘤39例，占97.5%，以生殖细胞肿瘤多见，黏液性囊腺瘤交界型1例；孕早期超声诊断8例，占孕期发现总例数的53.33%(8/15)；有4例出现并发症并行急诊手术，扭转3例，破裂1例，术前3例行CA125检查，2例升高，其中1例为黏液性囊腺瘤交界型；足月分娩38例，占95.00%。

In regarding the treatment of corneal dermoid depended on the extent of involvement of the cornea, lamellar keratoplasty in corresponding position can lower the recurrent rate.

治疗角膜皮样瘤应根据角膜受累程度采用不同的手术方式，相应部位的角膜皮样瘤切除联合板层角膜移植术可以减少术后复发的几率。

The estimated incidence of desmoid tumor in the general population is 2 to 4 per million people per year, according to the Desmoid Tumor Research Foundation.

据硬纤维瘤研究基金会的数字，硬纤维瘤在人群中的发病率估计在每年每百万人2-4人。

B, Color Doppler scan of a Desmoid tumor in a previous scar revealing some vascularity in the lesion.

图16，A，以前疤痕处的硬纤维瘤。B，彩色多普勒扫描以前瘢痕处的硬纤维瘤病变处显示一些血管供应。

We describe a case of Gardner syndrome with clinical manifestations including colonic and gastric polyposis, colon adenocarcinoma, abdominal desmoid tumor, and skull osteomas.

我们在此报告一个Gardner氏症的病例合并有大肠与胃瘜肉症、大肠癌、腹部硬纤维瘤与头部骨瘤。

Desmoplastic fibromas are rare, benign bone tumors that histologically resemble desmoid tumors of the soft tissue. Most examples of desmoplastic fibromas of the bone are discovered in patients younger than 30 years, and there is no gender predilection. A desmoplastic fibroma may involve any bone but is most frequent in the mandible.

致密纤维瘤是一种罕见的良性骨头肿瘤，在组织学和生物行为上和软组织的硬纤维瘤很相像，多半发生在小於30岁的年轻人，男女比例均等，好犯下颚骨或身体其它的长骨。

Results 12 cases as abdominal hernia (of which indirect hernia 9 cases, direct hernia 2 cases, femorocele 1 case), ultrasonography shows middle-high echo or linkage heterogeniety echo clumps; 8 cases as hydrocele, Ultrasonogram shows anechoic; 2 cases as cryptorchidism, ultrasonography shows normal testicular middle-echo; 4 cases as lymph node mass (of which lymphoma 2 cases, lymph node metastasis 1 case, lymph node inflammatory change 1 case), acoustic image shows low weak echo; 4 cases as substance mass (of which fibroma 1 case, spermatic cord tumor 1 case, Desmoid tumor 1 case, spermatic cord inflammation 1 case), Ultrasonography shows non-uniformity middle-highor low echo.

结果 12例为腹外疝（其中斜疝9例、直疝2例、股疝1例），声像图表现为中高回声或混杂性回声团块；8例为鞘膜积液，声像图表现为无回声；2例为隐睾，声像图表现为似正常睾丸样中等回声；4例为淋巴结包块（其中淋巴瘤2例、淋巴结转移1例、淋巴结炎性改变1例），声像图表现为低弱回声；4例为实质性包块（其中纤维瘤1例、精索肿瘤1例、韧带样瘤1例、精索炎症1例），声像图表现为非均匀性中高回声或低回声。

Results 26 cases,the intraspinal lipoma were five cases,three cases were teratoma,5 cases were the separation of fetal spinal cord,three cases were superficial sinus,4 cases were diastematomyelia.

结果 26例中，椎管内脂肪瘤5例，畸胎瘤3例，脊髓胎分出5例，皮毛窦3例，脊髓纵裂4例，隐性脊柱裂6例。

Result Among 39 cases with occult spinal dysraphism, the meningocele was 4 cases, the dorsal dermal sinus 7 cases, the spinal lipomas 19 cases, the primary tethered cord syndrome 5 cases, the diastematomyelia 2 cases, the sacrococcygeal teratoma 2 cases.

结果 脑脊膜膨出4例，背侧皮窦7例，脊柱脂肪瘤19例，原发性脊髓栓系综合症5例，脊髓纵裂2例，骶尾部畸胎瘤2例。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。