瘤

Objective:To explore the relationship of Survivin and VEGF expression in Colonic Adenomatous polyp and Colon Cancer.

目的 探讨非家族性大肠腺瘤性息肉及腺癌中生存素及血管内皮生长因子的表达，为预测腺瘤性息肉癌变提供理论基础。

Benign lesions that may slightly increase risk of developing invasive breast cancer include complex fibroadenoma, moderate or florid hyperplasia, sclerosing adenosis, and papilloma.

有些良性病损可增加得浸润性乳腺癌危险，这些病损包括复合纤维腺瘤、中度或鲜红样增生、硬化性腺病和乳头状瘤。

Only two mice out of six had tumors in Sp2/0-ehCGβadoptively transferred group, while all mice had tumors in control group.

Sp2/0-preS2/S在所有的小鼠均形成了实体瘤，其瘤重无显著性差异。

Purpose: To investigate the correlation between CT features and clinical and pathological findings of small adrenocortical adenoma.

肾上腺皮质腺瘤的CT表现报道不少，但对直径≤3.0cm的小腺瘤的CT表现特征与临床症状和病理基础的关系，文献报道较少，有待进一步研究[1～7] 。

Results A 18 year old patient presented with 2 month's history of ambiopia. Computed tomography scan showed a round focus with high intensity and contrast enhancement in the cerebellar vermis.

结果 患者 18岁，以复视 2个月就诊，CT显示小脑蚓部有圆形高密度影，组织学检查显示瘤细胞具有多形性，可见黄色瘤样细胞、多核或单核的巨细胞、Rothensal纤维和嗜酸性透明小滴。

Objective To investigate the inhibitory effects of aminoguanidine,a selective inhibitor of inducible nitric oxide synthase, on mice stomach cancer and its′mechanism.

目的：研究诱导型一氧化氮合酶选择性抑制剂氨基胍对皮下接种MFC胃癌细胞株小鼠的抑瘤作用，探讨其抑瘤机制。

DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.

诱导出的DC共同表达CD83和CD14分子，CD83分子表达明显高于国内报道；肝癌患者DC培养上清中TNF水平高于健康人，提示肝癌患者DC仍具一定的抗原呈递能力，适当调控可使其行使APC功能，以期在肝癌个体化疫苗中发挥作用；DC负载肝癌可溶性抗原后，抗原呈递能力降低，BCG HSP70可促进DC成熟，增加其抗原呈递能力，预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子；肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞，活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主，同时分泌较高水平Th1型细胞因子IL-12和TNF，并抑制4种肝癌细胞生长；冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤，提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用；用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽，在体外诱导肝癌特异性淋巴细胞，活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF，并具较强杀伤活性，此CTL同时具备NK细胞特征；DC对肿瘤细胞的抑制作用可能是通过吞噬实现的，Fas-L在DC抑制中也起一定作用；DC对人肝癌裸鼠皮下移植瘤的抑制率为97％；在肝癌DC疫苗的作用中，至少联合3种以上机制，即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。

Objective:To evaluate the diagnostic value of imaglology in nasopharyngeal angiofibroma.

鼻咽部血管纤维瘤的影像评价祝玉芬郭平珍△尚跃东崔进国马彪苏勤摘要目的：评价鼻咽部血管纤维瘤的影像诊断价值。

Objective To investigate the feasibility of endoscopic nasal surgery for nasopharyngeal angiofibroma to avoid complications of routine surgeries.Methods Retrospective analysis was performed for six patients'clinical records from June2002to June2004.Endoscopic nasal surgery and other techniques such as CT,MRI,digital substract angiography,Controlled-hypotention anesthesia and preoperative feeding artery embolism had been used.Results No complication had occurred.

目的 避免常规手术的并发症，探讨经鼻内镜引导下鼻咽纤维血管瘤切除术的可行性方法回顾性分析从2002年6月～2004年6月收治的6例经鼻内镜手术治疗的鼻咽纤维血管瘤患者的临床资料，术均行CT或MRI检查，了解瘤体小及部位，行字减影血管造影了解瘤体血供，术前采用供血动脉栓塞，术中采用控制性低血压技术。

Objective: To establish a liver cancer and its angiogenesis model in order to study the biology of tumor and their angiogenic in chick CAM.

目的：建立人肝癌鸡胚移植瘤及其血管生成模型，探讨建立模型所需的条件和影响因素，为肝癌移植瘤及其血管生成的相关研究提供一个简便实用的研究方法。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。