瘤

We found that 1 mutant EG4 cells showed typical characteristics of pluripotent stem cells which had no obvious difference with wild cells; 2 When induced by 10〓 M retinoic acid , mutant EG4 cells differentiated into adipocytes with high frequency compared with mutant cells, suggested that EGFR plays a role in adipocyte differentiation; 3 when injected into nude mice, mutant teratocarcinomas contained a large amount of connective tissues as well as skeletal muscle, while wild EG4 cells produced frequently cartilage, keratinocyte and neuroepithelium.

我们建立了稳定表达胞内区功能缺失的外源EGFR cDNA片段的EG4细胞，分析其生长分化特性，发现 1）突变型细胞可在未分化状态下维持长时间的增殖，表明EGFR对EG多能干细胞表型无明显影响；2）〓 M的维甲酸A(retinoid acid A，RA)诱导后，大部分对照组细胞分化为脂肪细胞，而突变型细胞分化为脂肪细胞的比例明显较少，表明EGFR在脂肪细胞的发育分化中具有一定的调节作用；3）畸胎瘤切片分析显示，突变型瘤组织分布有大量的未分化细胞和结缔组织，分化细胞以肌肉细胞为主；对照组瘤组织含丰富的角质上皮、软骨、神经管等依赖EGFR的分化组织。

Besides, The nodulation with else host experiment told us that NWGX035 could nodulate with melilotus suaveolens Ledeb, sophora alopecuroides Linn, lotus corniculatus Linn, sophora viciifolia Hance, trifolium repens Linn. The property of powerful salt, alkali, high temperature endurance and wide nodulation could confirm this strain was a particular strain.

另外，回接其它寄主植物的试验表明， NWGX035能与草木樨、黄化苦豆子、百脉根、狼牙刺和白三叶共生结瘤，其广泛的共生结瘤范围和强的耐盐、碱和抗(来源：A9fBC论文网www.abclunwen.com)高温特性可以证明该菌株为一株性状优良的菌株，其共生结瘤机制和耐盐碱机制需进一步研究。

Results 1. The expression of P53, KI-67, hTERT and ToPo II a protein was higher in astrocytoma than that in nomal brain tissue, the expression of these markers was obversely correlated to the grade of astrocytoma (P.05). The expression of Fas was higher in astrocytoma than that in nomal brain tissue, on the contrary, expression of P16 was lower in astrocytoma than that in nomal brain tissue.

结果 1、星形细胞瘤中P53、KI-67、hTERT与ToPoⅡα蛋白表达阳性率高于正常脑组织，P53、KI-67、hTERT与ToPoⅡα蛋白表达与星形细胞瘤的病理组织学分级呈显著正相关(P.05)；Fas蛋白在星形细胞瘤中的表达高于正常脑组织，而P16蛋白表达低于正常脑组织，Fas、P16蛋白表达与组织学分级无显著相关性。

Types include meningioma, astrocytoma, oligodendroglioma, and undifferentiated sarcoma.

种类包括：脑膜瘤、星形细胞瘤、少突胶质细胞瘤与未分化肉瘤。

Objective:To study the diagnostic and differential criteria for benign and malignant osteoblastoma.

骨母细胞瘤临床病理学研究李亦民丁彦青徐莉摘要探讨良性骨母细胞瘤和恶性骨母细胞瘤的诊断和鉴别诊断标准。

The distribution of PA I-1 protein was mainly in tumor cells of high-grade astrocytomas, particularly abundant in areas of vascular proliferation and in tumor cells surrounding necr otic foci, whereas it was only weekly expressed in low-grade astrocytomas.

PAI-1蛋白主要分布在高级别星形细胞瘤的瘤细胞和内皮细胞，尤以血管增殖部位和坏死灶周围较为显著，低级别星形细胞瘤呈低表达。

Results 1 The incidence of parovarian cyst was 20.9% in all adnexal cysts.175 cases(91.62%) were pure cysts;15 cases(7.85%) were common epithelial ovarian tumors13 cases were serous cystadenoma;1 case was focal or junctional serous papillary cystadenoma;1 case wa...

结果191例卵巢冠囊肿患者中有175例(91.62%)为单纯囊肿；15例(7.85%)为上皮性囊肿(其中13例为浆液性囊腺瘤，1例为浆液性乳头状囊腺瘤灶性交界，1例为副中肾管源囊腺瘤、腺体增生并中重度非典型性增生)；1例(0.53%)为高分化乳头状间皮瘤。

Methods DCs were prepared from peripherad blood mononuclear induce d with gra-nulocyt e/macrophage colony-stimulating factor and interleukin-4. Apoptosis of glioma cells were induced with γ-radiation. We design these experiment groups including (1) coculture of DCs and apoptotic glioma cells and T cells,(2) coculture of DCs and U937 cells and T cells,(3) coculture of DCs and cultured glioma cell and T cells,(4) coculture of Des and T cell.

用粒－巨噬细胞集落刺激因子加白介素－4(IL-4)从人外周血分化、诱导DCs、γ-射线在体外诱导培养的人脑胶质瘤细胞凋亡，将DCs、T淋巴细胞和凋亡胶质瘤细胞共培养，同时设计不同类型肿瘤细胞（U937及培养胶质瘤细胞）作对照，分离、富集DCs、T淋巴细胞进行免疫应答及肿瘤细胞杀伤试验。

Many tumor specific antigens such as mouse PlA, human MAGE, BAGE and GAGE families had been isolated during recent decade. PlA is a tumor specific antigen expressed by mouse mastocytoma P815. It is one kind of cancer-testis antigens and expresses in various mouse tumor such as mastocytoma P815, plasmoma J558 and fibrosarcoma Meth A but hardly in normal tissue except testis and placenta.

近十年来已经成功分离出多种鼠或人的肿瘤特异性抗原，如小鼠P1A基因和人的MAGE、BAGE、GAGE家族等。P1A为小鼠肥大细胞瘤P815所表达的肿瘤特异性抗原，它是一种CT抗原，在多种小鼠肿瘤如肥大细胞瘤P815、浆细胞瘤J558和纤维肉瘤Meth A等中表达，而在除睾丸、胎盘之外的正常组织中不表达。

In contrast to plexiform neurofibromas, plexiform schwannoma is only weakly associated with neurofibromatosis type 1 (von Recklinghausen's disease), and has little malignant potential.

相对於丛状神经纤维瘤，丛状神经鞘瘤与第一型予纤维瘤病(neurofibromatosis type 1，von Recklinghausen's disease)的相关很薄弱，而且没有恶性变化的倾向。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。