瘢痕疙瘩

Adding dividedly the solution of two drugs with different concentration into the heperplastic scar fibroblasts and keloid fibroblast which were in logarithmic growth phase. After 48 hours in vitro culture, hydroxyproline colorimetric test was conducted, then statistics comparison was carried out in accordance with hydroxyproline content which was calculated based on OD value.

向对数生长期的增生性瘢痕成纤维细胞及瘢痕疙瘩成纤维细胞中加入不同浓度的两种药液，培养48小时后进行羟脯氨酸比色试验，并将 OD 值依公式换算成羟脯氨酸含量，进行统计学比较。

Methods Nuclear β-catenin expression was detected by immunohistochemistry in 77 lesions with desmoid-type fibromatosis and 171 other spindle cell lesions, including superficial fibrmoatosis (n=18), nodular fasciitis (n=36), keloid (n=16), scar (n=10), granulation tissue (n=9), synovial sarcoma (n=38), neufibroma (n=13), solitary fibrous tumor (n=12), gastrointestinal stromal tumor (n=10), low-grade myxofibrosarcoma (n=3), low-grade fibromyxoid sarcoma (n=3), and smooth muscle tumor (n=10). In addition, the immunohistochemical expressions of ER-α, ER-β and Ki-67 were examined in all of the lesions with desmoid-type fibromatosis. The nuclear immunohistochemical staining for nuclear βcatenin and ER-β was graded as high level (≥25% of cells), low level (5%-25%) or none.

采用免疫组织化学染色法检测77例韧带样型纤维瘤病和171例其它良、恶性梭形细胞病变（包括结节性筋膜炎36例、浅部纤维瘤病11例、瘢痕疙瘩16例、增生性瘢痕10例、肉芽组织9例、滑膜肉瘤38例、神经纤维瘤13例、孤立性纤维性肿瘤12例、胃肠间质肿瘤10例、低度恶性黏液纤维肉瘤3例、低度恶性纤维黏液样肉瘤3例及平滑肌肿瘤10例）组织中β-catenin核阳性的表达，同时检测韧带样型纤维瘤病中ER-α、ER-β和Ki-67的表达。

Connective tissue growth factor may play an important role in promoting the fibrotic process of hypertrophic scar and keloid tissue.

结论结缔组织生长因子在增生性瘢痕和瘢痕疙瘩纤维化进程中可能起着促进作用

The protein levels of periostin in KFb (91.815±0.961) and HFb (70.166±2.250) were both higher than that in SFb (41.011±1.576, P.01). Conclusion: The expressions of periostin were increased in the fibroblasts of hyperplasic scars, which could be inhibited by hycirocortisone.

Periostin蛋白主要分布在成纤维细胞核周围的胞浆中，它在瘢痕疙瘩和增生性瘢痕的成纤维细胞中的表达（分别为91.815±0.961和70.166±2.250）高于在正常皮肤成纤维细胞中的表达(41.011±1.576， P.01)，两者分别增加55%和42%。

Objective:To investigate the expression of vascular endothelial growth factor in keloids and hypertrophic scars.

目的：探讨瘢痕疙瘩和增殖性瘢痕中血管内皮生长因子的表达及其意义。

OBJECTIVE: To explore the feasible therapeutic way according to the development of cheloid and hypertrophic scar in recent years.

目的：根据近年来对瘢痕疙瘩和增生性瘢痕治疗研究的进展，探讨其可行的治疗方法。

Objective properly deal with open wounds to check and prevent scars from overgrowing and the producing of the keloids.

目的：正确处理开放性伤口，预防瘢痕过度生长或瘢痕疙瘩的形成。

properly grasping every link of the trentment of open wounds within soft tissues can check and prevent scars from overgrowing and the producing of the keloids to the utmost.

正确把握开放性伤口治疗过程的每一个环节，即能最大限度的预防瘢痕过度生长或瘢痕疙瘩的形成。

Objective To investigate the expression of vascular endothelial growth factor and proliferating cell nuclear antigen in keloids and hypertrophic scars.

目的 探讨瘢痕疙瘩和增殖性瘢痕等异常疤痕中血管内皮生长因子和增殖细胞核抗原的表达及其意义。

Objective To investigate theexpression of vascular endothelial growth factor and proliferating cell nuclearantigen in keloids and hypertrophic scars.

目的 探讨瘢痕疙瘩和增殖性瘢痕等异常疤痕中血管内皮生长因子和增殖细胞核抗原的表达及其意义。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。