瘢痕疙瘩

To evaluate the validity of antipruritic ointment for cicatrix in the treatment of keloids. Fifty patients of keloids had used antipruritic ointment for cicatrix third per day for six months.

评价疤痕止痒软化乳膏治疗瘢痕疙瘩的有效性。50例瘢痕疙瘩患者使用疤痕止痒软化软膏每日3次，连续治疗6个月。

Objective To examine the expression of p44/42 mitogen -activated protein kinase (p44/42MAPK) and Phospho-p44/42MAPK in cicatrix and to aim at exploring the role of activated p44/ 42 MAPK pathway in development of cicatrix.

目的 研究丝裂素原激活的蛋白激酶(p4 4 / 4 2MAPK)在异常瘢痕(瘢痕疙瘩和增生性瘢痕)中的表达和激活情况，探讨该信号通路在瘢痕形成中的作用。

OBJECTIVE: To study the relationship between intracellular actin and scar contracture.

目的 探讨增生性瘢痕、瘢痕疙瘩成纤维细胞中肌动蛋白与瘢痕挛缩的关系。

Results Compared to those before treatment the volume of the implanted keloid of Group D began to decrease since 14 days after treatment time-dependently (all P 《 0.05), and the volumes of the other 3 groups continued to increase and peaked on days 21, 14, or 7 respectively (all P 《 0.05).Microscopy showed infiltration of a larger quantity of histiocyte in the keloid tissue, and more obvious collagen disorganization and apoptosis of fibroblasts in Group D than in the other 3 groups.The protein expression of Bcl-2 was more remarkable and the protein expression of BAX was less remarkable in Group D than iu the other 3 groups.

结果 用药前和用药后7、14、21、28、35 d，D组瘢痕疙瘩组织块体积(mm3)分别为173±5、172±5、147±5、125±6、112±7和84±9，从用药后14 d开始明显缩小(均P＜0.05)；而其他3组瘢痕疙瘩组织块体积均明显增大，从用约后7 d开始各时点测得的体积均明显大于D组(均P＜0.05)。D组瘢痕疙瘩组织中有大量小鼠组织细胞浸润，胶原结构破坏和成纤维细胞凋亡明显重于其他3组，Bcl-2蛋门质表达明显弱于而Bax蛋白质表达明显强于其他3组。

RESULTS: These familial keloids mainly occurred during adolescence, showing the equal chance of being affected between male and female subjects. The affected person could be heterozygous, and a child of an affected parent had a 50% chance of being affected. Thirteen subjects displayed familiar keloid, 1 suspected keloid, 2 did not present keloid as obligate carriers, and 1 did not present keloid as doubtful carrier. One pedigree displayed keloid in 3 generations, two displayed in 2 generations. The traits of familial keloids were transmitted interruptedly, revealing incomplete penetrance. The clinical phenotypes of familial keloids presented variable expression among the different affected.

结果：这些瘢痕疙瘩家系以青春期发病为主，男女患病的机会均等；杂合体即可发病，双亲之一发病其半数子女可能发病；3个瘢痕疙瘩家系发病13人，可疑发病1人，2个未发病肯定携带者，1个未发病可疑携带者；3代发病家系1个，2代发病家系2个；瘢痕疙瘩性状存在间断传递、外显不完全现象；临床表型存在个体差异。

The results suggest that immunologic factors may play an important role in the pathogenesis of keloid.

免疫因素可能在瘢痕疙瘩发病机理中具有重要作用，且对瘢痕疙瘩的发展有较大影响。

Objective To investigate the correlation between the body constitution type of TCM and the clinical characteristic in the patients with keloid.

目的：探讨瘢痕疙瘩的中医体质类型与临床特征间的关系，为瘢痕疙瘩的治疗提供依据。

Results:The positive rates of TSP- 1 mRNA in hypertrophic scars and keloid were lower than those in normal skin and surgical scar. MVC was higher in the cases with negative expression of TSP - 1 mRNA than the ones with positive expression of TSP - 1 mRNA. MVC was higher in the hyperstrophic scar and keloid than in normal skin and surgical scar.

结果TSP-1 mRNA在增生性瘢痕和瘢痕疙瘩中表达的阳性率低于在正常皮肤和外科瘢痕组织中的表达(P＜0.05)；TSP-1 mRNA表达阴性病例组的MVC显著高于TSP-1 mRNA阳性病例组的MCV(P＜0.05)；增生性瘢痕和瘢痕疙瘩组织中微血管数多于正常皮肤和外科瘢痕组织的微血管。

the fibroblasts are activated in collagen synthesis in active keloid. The enhanced collagen synthesis by fibroblasts is a critical factor leading to the overabundant collagen accumulation in keloid.

结论在活跃增生的瘢痕疙瘩中，成纤维细胞胶原合成功能处于活化状态，胶原合成增加是瘢痕疙瘩中胶原过度积聚的重要原因。

Objective: To approach the possible effects of syndecan-4 in theformation of keloid and provided a new method to prevent and treat keloids.

目的探讨多配体蛋白聚糖—4(Syndecan—4简称SDC4)对瘢痕疙瘩形成的促进作用，为预防和治疗瘢痕疙瘩提供新思路。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。