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The recombinant antisense GFAP retrovirus can effectively inhibit the growth of glial cicatrix formation in vivo. This result provides a new way for delaying or suppressing glial cicatrix formation by the technique of gene engineering.

重组反义GFAP逆转录病毒能在一定程度上减少胶质瘢痕形成,为利用基因工程技术延缓或抑制胶质瘢痕形成提供了新的实验依据。

Objective To examine the expression of p44/42 mitogen -activated protein kinase (p44/42MAPK) and Phospho-p44/42MAPK in cicatrix and to aim at exploring the role of activated p44/ 42 MAPK pathway in development of cicatrix.

目的 研究丝裂素原激活的蛋白激酶(p4 4 / 4 2MAPK)在异常瘢痕(瘢痕疙瘩和增生性瘢痕)中的表达和激活情况,探讨该信号通路在瘢痕形成中的作用。

Methods A recombinant antisense GFAP retrovirus was developed. After packing and concentrating, the suspension of this retrovirus was injected into the sites of injured brain stab by a microinjector. The effect of recombinant antisense GFAP retrovirus on formation of glial cicatrix in the injured sites was studied through immunohischemistry and morphological observation.

构建反义GFAP逆转录病毒表达载体,经过病毒包装后,将获得的病毒上清液浓缩并通过微量注射的方法,引入大鼠脑穿刺损伤灶内,采用免疫组化及形态学观察的方法,研究重组反义GFAP逆转录病毒对脑损伤后胶质瘢痕形成的影响。

RESULTS:①Westem blot of the tendons in experiment group demonstrated the up-regulation of TGF-β receptor protein levels, which mainly appeared in the tendon sheath, the epitendineum and the incision along the repair site.

肌腱损伤修复后,肌腱和腱鞘转化生长因子β1受体的表达明显增加,在术后14d达到高峰,56d开始降低,这种受体上调可能为屈指肌腱术后瘢痕形成的生物学调节提供新的途径。

Methods Constructed the model of fetal scarless wound healing and investigated the expression of collagen in fetal and adult rat wounds by immunohistochemistry and in situ hybridization.

染色,Ⅰ、Ⅲ型胶原免疫组化,Ⅰ、Ⅲ型胶原原位杂交。结果胎鼠伤口愈合快,组织结构再生完全,没有瘢痕形成,胶原呈网状正常排列,Ⅰ、Ⅲ型胶原蛋白及表达均增多,同时伴细胞数增多,Ⅲ型胶原首先形成网状排列;成年伤口胶原纤维沉积慢,平行排列的胶原逐渐呈束状填塞伤口以致瘢痕形成,伤口内Ⅰ、Ⅲ型前胶原mRNA表达均增多,细胞数目增多不明显。

Objective properly deal with open wounds to check and prevent scars from overgrowing and the producing of the keloids.

目的:正确处理开放性伤口,预防瘢痕过度生长或瘢痕疙瘩的形成。

properly grasping every link of the trentment of open wounds within soft tissues can check and prevent scars from overgrowing and the producing of the keloids to the utmost.

正确把握开放性伤口治疗过程的每一个环节,即能最大限度的预防瘢痕过度生长或瘢痕疙瘩的形成。

Methods Cut the scar along it's length with operation knife to form a scar-skin which thickness is of about 0.8~1.2mm,then cut off the scar tissues under the scar-skin,replant the scar-skin in the same place,enswathed the wound with proper pressure.

沿瘢痕纵轴在瘢痕内切口,手术刀锐性剥离,形成0.8~1.2mm厚的瘢痕皮,切除瘢痕皮下的瘢痕组织,将瘢痕皮原位回植,适当加压包扎。5~10天拆线,应用肤康霜或硅酮霜3~6个月。

Objective: To probe into the role of periostin in the formation of scars and investigate its reaction to hydrocortisone.

目的:通过检测periostin在人过度增生性瘢痕成纤维细胞中的表达及其对氢化可的松作用的反应,探讨periostin在瘢痕形成中的作用。

Wound healing is a dynamic, interactive process involving soluble mediators, blood cells, extracellular matrix, and epidermal cells. It has about five phases, haemostasis, inflammation, epithelialization, remodelling and scar formation.

创伤修复的过程是一个众多可溶性生长、细胞因子、血细胞、胞外基质和皮肤细胞参与,涉及止血、炎症发生、上皮再生、组织重建、瘢痕形成的一个复杂的动态过程。

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他们没有侵略性,但我大喊,并在他们的方向扔石头让他们过的线索,远离我,以防万一。

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在你的书包里槽2把包装纸、数量无关紧要。

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密封,遮光,置阴凉干燥处。