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Objective To study the relationship between intra cellular actin and scar contracture.

目的 探讨增生性痕、痕疙瘩成纤维细胞中肌动蛋白与痕挛缩的关系。

Methods 15 patients with different type and degree of cicatricial ectropion were repaired with the method of simple skin grafting, posterior auricular refluxing axial skin flap or anchyloblepharon.

对15例不同类型和不同程度的痕性睑外翻,采用局部痕松解睑缘粘连、耳后返流轴型皮瓣修复及痕松解植皮修复。

Results Compared to those before treatment the volume of the implanted keloid of Group D began to decrease since 14 days after treatment time-dependently (all P 《 0.05), and the volumes of the other 3 groups continued to increase and peaked on days 21, 14, or 7 respectively (all P 《 0.05).Microscopy showed infiltration of a larger quantity of histiocyte in the keloid tissue, and more obvious collagen disorganization and apoptosis of fibroblasts in Group D than in the other 3 groups.The protein expression of Bcl-2 was more remarkable and the protein expression of BAX was less remarkable in Group D than iu the other 3 groups.

结果 用药前和用药后7、14、21、28、35 d,D组痕疙瘩组织块体积(mm3)分别为173±5、172±5、147±5、125±6、112±7和84±9,从用药后14 d开始明显缩小(均P<0.05);而其他3组痕疙瘩组织块体积均明显增大,从用约后7 d开始各时点测得的体积均明显大于D组(均P<0.05)。D组痕疙瘩组织中有大量小鼠组织细胞浸润,胶原结构破坏和成纤维细胞凋亡明显重于其他3组,Bcl-2蛋门质表达明显弱于而Bax蛋白质表达明显强于其他3组。

RESULTS: These familial keloids mainly occurred during adolescence, showing the equal chance of being affected between male and female subjects. The affected person could be heterozygous, and a child of an affected parent had a 50% chance of being affected. Thirteen subjects displayed familiar keloid, 1 suspected keloid, 2 did not present keloid as obligate carriers, and 1 did not present keloid as doubtful carrier. One pedigree displayed keloid in 3 generations, two displayed in 2 generations. The traits of familial keloids were transmitted interruptedly, revealing incomplete penetrance. The clinical phenotypes of familial keloids presented variable expression among the different affected.

结果:这些痕疙瘩家系以青春期发病为主,男女患病的机会均等;杂合体即可发病,双亲之一发病其半数子女可能发病;3个痕疙瘩家系发病13人,可疑发病1人,2个未发病肯定携带者,1个未发病可疑携带者;3代发病家系1个,2代发病家系2个;痕疙瘩性状存在间断传递、外显不完全现象;临床表型存在个体差异。

Objective: To investigate the possibility of pathologic scars treated in endostatin , by observing the effects of endothelial cell and neogenesis capillary of pathologic scars treated in endostatin , through establishing models of hyperplastic scar in rabbit ear and injecting Endostatin .

目的:建立兔耳增生性痕的动物模型,并采用内皮抑素局部在体干预,观察其对病理性痕新生毛细血管及血管内皮细胞的影响,以探讨内皮抑素防治病理性痕的可行性。

Objective: To explore the effects of NGF on the fibroblasts of scars in biological behavior and pathological change. It can provide the basic of theory in molecular biology and pathobiology. Methods: Wounds were created on a Sprague-Dawley rat model.

目的:探讨神经生长因子对痕成纤维细胞生物学行为的影响、病理改变及其对痕的作用机制,为临床预防和治疗痕提供分子及病理学水平的理论依据。

In order to investigate the inhibitory effect of salvia miltiorrhiza and tetramethyl pyrazine on scartricial fibroblast, the hypertrophic scar tissue of chest was chosen for culture of fibroblasts, and the influence of SM and TP on fibroblasts was observed, The effect of the drugs on the growth of fibroblasts, on DNA synthesis of fibroblasts and on mitosis index of fibroblasts were all determined quantitatively.

摘 要 增生性痕是临床治疗难题之一,目前尚无有效的治疗方法。为了探讨丹参和川芎嗪对痕成纤维细胞的抑制作用,取12例患者胸部增生性痕组织,通过体外成纤维细胞培养,探讨不同药物浓度、不同作用时间对成纤维细胞生长的影响。

Result: the reasons of hand burn scar contracture in 74 cases included deepened infection due to inappropriate treating the wound surface in the early stage, the form of hyperplastic scar due to failing to accept the dermoplasty in deep ii burn and late operation or thin free skin graft in deep burn and inadequate rehabilitation exercise after operation.

结果:74例手烧伤后痕挛缩畸形产生的主要原因为:①创面早期处理不当致感染加深;②深II度烧伤病人不接受植皮而形成增生性痕;③深度烧。。。本文由网友上传,与本网无关摘要:探讨手部烧伤后痕挛缩畸形较为有效的防治方法。

The expression of VEGFmRNA was valued by in situ hybridation method and the expression of Fit-1 and MV count was investigated by using immunohistochemical method.

应用原位分子杂交方法研究VEGFmRNA的表达,应用免疫组化方法研究Flt-1表达及MV的计数。结果:增生性痕和痕疙瘩组织中MV数目多於正常皮肤和扁平痕组织中的MV数目。

RESULTS: Psilotic scar eliminated in all cases, but 11 cases underwent scalp scar excision, transposition of local flap and autologous hair transplant because of wide incisional scar or residual small alopecia.

结果:全部病例均能消除秃发的痕,术后11例因切口痕过宽或残留小面积秃发区,行头部痕切除、局部皮瓣转位、自体毛发移植等治疗后修复,无明显并发症发生。

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The relationship between communicative competence and grammar teaching should be that of the ends and the means.

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这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。