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Objective By using Alzheimer's model rats induced by AlCl3,the effects and mechanism of Ginkgo flavone were investigated.Methods Ginkgo flavone were given to rats by oral for seven weeks.Then,the ability of study of mice were determined by step-down test and the number of neurons in the Bregma hippocampus containing β-APP proteins were counted.

目的 研究银杏黄酮对三氯化铝所致痴呆模型鼠学习记忆能力和海马内β-APP阳性神经元的影响,以期探讨银杏黄酮抗老年性痴呆的作用机制方法用三氯化铝致老年性痴呆模型大鼠实验对象,以其学习记忆能力、背海马和齿状回内β-APP阳性神经元的量为指标,全面考察银杏黄酮抗老年性痴呆的作用。

objective by using alzheimer's model rats induced by alcl3,the effects and mechanism of ginkgo flavone were investigated.methods ginkgo flavone were given to rats by oral for seven weeks.then,the ability of study of mice were determined by step-down test and the number of neurons in the bregma hippocampus containing β-app proteins were counted.results to the model rats,ginkgo flavone 100,200,400mg?

目的 研究银杏黄酮对三氯化铝所致痴呆模型大鼠学习记忆能力和海马内β-app阳性神经元的影响,以期探讨银杏黄酮抗老年性痴呆的作用机制。方法用三氯化铝致老年性痴呆模型大鼠为实验对象,以其学习记忆能力、背海马和齿状回内β-app阳性神经元的数量为指标,全面考察银杏黄酮抗老年性痴呆的作用。

A retrospective clinico-pathologic study of 100 patients with autopsy proven PD (including 44 cases with dementia/PDD) and 20 cases of dementia with Lewy bodies confirmed essential clinical (duration of illness, Mini-Mental State Examination/MMSE, age at death) and morphologic differences between these groups; Lewy body Braak scores and Alzheimer pathologies (neuritic Braak stage, cortical Aβ plaque load, and generalized cerebral amyloid angiopathy or CAA) were significantly higher/more severe in DLB and PDD than in PD without dementia.

一项关于100例经尸检证实为帕金森病(44例并发痴呆或帕金森病痴呆)和20例路易体痴呆的回顾性临床病理研究证实了其关键的临床表现(病程、MMSE评分,死亡年龄)和形态学差异。结果表明,路易体病和帕金森病痴呆患者的路易体Braak评分和阿尔茨海默病病理学改变较未并发痴呆的帕金森病患者更为严重。

Methods assessment and comparison were made with mini-mental state examination and sandoz clinical assessment geriatric to 31 hospitalized patients with senile dementia (15 cases with alzheimer disease, ad, and 16 cases with multi-infarct dementia, md) before treatment and 4 weeks after treatment.results small dosage of olazapine could improve the psychotic symptoms of the patients with senile dementia; the total score of mmse after treatment increased obviously, and each factor score of scag showed out improvement.conclusions olazapine is effective in improving the psychotic symptoms of the patients with senile dementia.

对31例老年性痴呆(阿尔茨海默病15例和多发性脑梗死性痴呆16例)住院患者在治疗前、治疗后4周,采用简易智能状态检查及老年临床评定量表进行评定、比较。结果应用奥氮平治疗老年性痴呆患者的精神症状用量小,治疗后mmse总分明显增加。scag各项因子分明显改善。结论奥氮平治疗老年性痴呆的精神病性症状临床疗效肯定。

A recent study suggested that people in their forties with belly fat have an increate increased risk of dementia ( n.阿尔茨海默氏痴呆,痴呆) later in life.

一项最近的研究发现40-50岁的肥胖的人在以后很容易罹患痴呆症。

It was also found that the dementia group tended to have lower premorbid levels of cognitive functioning. Conc lusion: Sig nificant group differences in MMSE scores across the assessment intervals sugges ted different courses of cognitive change in normal aging and dementia.

痴呆老人MMSE分数变化前后5年及10年间均显著高于无痴呆老人,提示正常老化与痴呆的认知功能衰退模式不同。

It was also found that the dementia group tended to have lower premorbid levels of cognitive functioning. Conc lusion: Sig nificant group differences in MMSE scores across the assessment intervals sugges ted different courses of cognitive change in normal aging and dementia.

痴呆老人颈椎病 MMSE分数变化前后5年及10年间均显著高于无痴呆老人颈椎病,提示正常老化与痴呆的认知功能衰退模式不同。

Effect of Fufangdanshendiwan for the treatment of vascular dementia has obvious effects, in particular, together with other puzzle drugs; can significantly slow down the process of vascular dementia; Fufang Danshen Diwan also use simple, the medication compliance Good, safe, vascular dementia can use the Effect of Fufangdanshendiwan treatment, in clinical worth promoting.

复方丹参滴丸用于治疗血管性痴呆有明显的疗效,尤其是联合其他益智药,能够明显延缓血管性痴呆的进程。复方丹参滴丸用法简单,服药的依从性好,安全性高。因此,血管性痴呆可以使用复方丹参滴丸治疗,在临床上值得推广。

Whether the effects of stroke merely unravel an ongoing underlying dementing process or in fact cause the dementia has implications for the prevention of dementia in persons with cerebrovascular disease.

不论中风的效应仅仅是促进了痴呆者的发病进程,或是痴呆的病因,对于防止脑血管疾病患者发生痴呆都有意义。

Results: Among 140 patients with cerebral infarction, 32 patients suffered vascular dementia (22.9%, 32/140). Freguent onsets (≥2), large areas and multiple infarction are the risk facto for the vascular dementia following cerebral infarction.

结果:其中32例患者发生血管性痴呆,脑梗死后血管性痴呆的患病率为22.9%(32/140),发病次数≥2次、大面积及多发性梗死是脑梗死后血管性痴呆发生的重要危险因素。

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