痛风

Methods 26 cases were treated by oral administration of amlodipine 5 mg, berberine 0.3g, meanwhile treated the acute arthrolithiasis by oral administration of colchicine 0.5mg, reated hypertensive with chronic gout by oral administration of allopurinol 100mg.

方法选择轻、中度老年高血压患者26例，给予患者口服氨氯地平5mg，1次/d，小檗碱0.3g，3次/d，同时给予急性痛风患者，口服秋水仙碱0.5mg，慢性痛风患者，口服别嘌呤醇100mg。

OBJECTIVE: To compare high-resolution ultrasound with conventional radiography in the detection of erosions in the first metatarsophalangeal joints (1st MTPJs) of patients with gout and to identify the characteristic sonographic features of gout.

目的：在第一跖趾关节（1st MTPJs）糜烂的痛风患者中比较高分辨率超声与常规X射线检测，并确定特征性痛风的超声表征。

Arthroscopic elimination of monosodium urate deposition of the first metatarsophalangeal joint reduces the recurrence of gout.

关节镜清除第一跖趾关节的痛风晶体可降低痛风关节炎急性发作次数，并增加足部和踝部功能。

Single joint was involved in two and multiple lesions in five of them,including the knees,elbow,wrist,phalangeal joint,metatarsophalangeal joint,metacarpophal...

根据病变严重程度分别采用关节抽吸冲洗类固醇注射、关节镜下病变清理术、痛风病灶清除术、刮除植骨术、Keller's手术及关节融合术治疗痛风病灶。

Hyperuricemia and acute gouty arthritis model was made with Oxonic Acid potassium and Sodium Urate injected into abdominal cavity and right ankle joint cavity respectively .

组和痛风速效灵组，用氧嗪酸钾和尿酸钠分别行腹腔和右踝关节腔内注射制造高尿酸血症并急性痛风性关节炎模型。

Results(1) Group of electroacupuncture in Shu and dense wave can significantlyreduce the degree of ankle swelling(P＜0.05, P＜0.01), which shows thatelectroacupuncture has obvious anti-inflammatory and repercussive roles;(2) Theresults of HE staining showed that group of electroacupuncture in Shuand dense wave can significantly reduce inflammatory cell infiltration,inhibit synovial cell proliferation, and decrease proliferation of granulationtissue in rats joints;(3) group of electroacupuncture in dense-wave can increase the pain thresholdof experimental rats (P＜0.05, P＜0.01), reduce the content of peripheral painmediums, such as K~+, DA and 5-HT(P＜0.05, P＜0.01), which shows thatelectroacupuncture has significant analgesic effect;(4) In the local lesion of joints, electroacupuncture can significantly reducethe content of IL-1β, IL-8, TNF-a, increase IL-4 content, decrease theexpression of COX-2mRNA, and significantly promote the expression ofHSP-70 protein in synovial tissues of acute gouty arthritis rats (P＜0.05,P＜0.01),thus restrain the occurrence of synovial tissue inflammation.

结果：(1)电针疏密波组能显著减轻踝关节肿胀度(P＜0.05，P＜0.01)，表明电针有明显的抗炎消肿作用；(2)HE染色显示：电针疏密波组可使大鼠关节炎症细胞浸润明显减轻，滑膜细胞增生明显被抑制，肉芽组织增生明显减少；(3)电针密波组能提高实验性大鼠痛阈(P＜0.05，P＜0.01)，降低外周疼痛介质K~+、DA、5-HT的含量(P＜0.05，P＜0.01)，表明电针有明显的镇痛作用；(4)在病变关节局部，电针能显著降低急性痛风性关节炎大鼠滑膜组织IL-1β、IL-8、TNF-α含量(P＜0.05，P＜0.01)，升高IL-4的含量(P＜0.05，P＜0.01)，并降低关节滑膜内COX-2mRNA的表达(P＜0.05，P＜0.01)，可促使急性痛风性关节炎大鼠滑膜内HSP-70蛋白表达显著增加(P＜0.05，P＜0.01)，从而抑止滑膜组织炎症发生。

These data show that HRUS may assist in the management of gout in two ways: first, by aiding in the diagnosis by identifying the sonographic features that may be representative of the disease, and, second, by allowing the early detection of erosive joint damage and/or tophaceous deposits even in clinically silent joints.

这些数据表明HRUS可能在两方面协助痛风的治疗：第一，通过确定可能代表疾病的超音波特征协助诊断，第二，允许糜烂关节损害和/或痛风石沉积物的早期检测，即使在临床沉默的关节上也是如此。

Tophaceous gout results from continued precipitation of sodium urate crystals during attacks of acute gout.

沙粒状痛风是由急性痛风发作期尿酸钠盐结晶继续析出引起。

There are many different opinions about pathogeny and pathological mechanism of acute gout arthritis, but the real cause is uncertain. It is considered that the tiny crystal of uric acid salt aggraded near arthrosis, and leaded to a series of inflammation reaction.

研究方法本研究将符合痛风关节炎临床诊断的60例病人随机分为西药对照组(30例)与痛风利消汤治疗组(30例)，6天为一个疗程，将治疗前后临床症状及主要实验室指标进行统计学分析。

In patients with tophi and without tophi, the-308 allele carriage of the A allele was 12.2% and 2.5%, respectively p=0.035, odds ratio

而在有痛风石和没有痛风石病人中，带有一个A对偶基因的比例分别是12.2%及2.5% p=0.035， odds ratio 4.87， 95% C.I。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。