痛觉过敏

"Such findings suggest that the relationship between disturbed sleep and pain is bidimensionsal not only does pain disrupt sleep, but disrupted sleep may enhance pain," Timothy A Roehrs, PhD, lead investigator, told Medscape."We were interested in determining whether loss of REM sleep itself is hyperalgesic."

Timothy A Roehrs博士向Medscape表示，这项试验结果显示，被干扰的睡眠与疼痛之间的关系是双向性的；亦即，疼痛不仅会阻扰睡眠，睡眠受到阻扰也会加强疼痛的感觉；我们想要探究的是，短少的REM睡眠，本身是否就是痛觉过敏。

In addition, IT injection of the -2 adrenoceptor antagonist, idazoxan (40 g/rat) 10 minbefore clonidine injection completely reversed clonidine'santi hyperalgesic and anti allodynic effects, as well as clonidine'ssuppressive effect on CCI-induced NR1 phosphorylation in thespinal cord dorsal horn.

另外，可乐定可以抑制 CCI 导致的脊髓背侧角 NR1磷酸化，但是在注射可乐定之前10min ，鞘内注射α－2受体拮抗剂咪唑克生(40 g/小鼠)，可以完全逆转其对抗痛觉过敏的效果。

In this study, we evaluated thepostoperative antihyperalgesic effect of intrathecal clonidineafter caesarean delivery.

在此研究中，作者评估了鞘内可乐定注射剖腹产术后抗痛觉过敏作用。

RESULTS: The capsaicin receptor TRPV1 is a polymodal nociceptor exhibiting a dynamic threshold of activation that could be lowered under inflammatory conditions.

结果：辣椒素受体TRPV1是一种多模式伤害性感受器，具有可在炎性情况下降低的动态激活阈值，与此模式一致的是TRPV1敲除的小鼠缺乏炎症后热性痛觉过敏。

In the noninflammatory model, 2 unilateral injections of acidic saline into the gastrocnemius muscle produced bilateral cutaneous and muscle hyperalgesia 24 hours after the second injection.

在非炎症性模型中，向单侧腓肠肌注射酸性saline液2次，在第二次注射后24小时，可产生双侧皮肤和肌肉痛觉过敏。

In thisstudy, we sought to determine whether perineural RTX preventshyperalgesia in a model of incisional pain.

本研究中，我们试图在一个切割性疼痛模型上判定神经周围应用 RTX 是否能预防痛觉过敏。

Peripherial tissue and nerve injury leads to chronic pain symptoms, including spontaneous pain, allodynia and hyperalgesia.

周围组织和神经受到损伤引起自发性疼痛、痛性感觉异常和痛觉过敏等慢性痛症状。

BACKGROUND: Spinally administered non- N -methyl-d-aspartate, but not NMDA, receptor antagonists block primary (1°) and secondary (2°) mechanical hyperalgesia and spontaneous pain after plantar incision.

背景：鞘内给予非 N-甲基-d-天冬氨酸受体拮抗剂可阻断足底切皮后原发性（1°）和继发性（2°）机械痛觉过敏和自发痛，而鞘内给予 NMDA 受体拮抗剂并无此作用。

RESULTS: Transection of the tibial and sural nerves inducedcold allodynia and moderate mechanical hyperalgesia.

结果：胫神经和腓肠神经的横断导致异常性冷疼痛和中等强度的机械性痛觉过敏。

The study suggested that TNF〓 and IL-1〓 might be produced in the cascade of events resulting in Wallerian degeneration and hyperalgesia following peripheral nerve compression, and increased TNF〓 and IL-1〓 mRNA may trigger other later responses in nervous system contributing to the initiation of peripheral neuropathic pain or other degeneration/regeneration processes.

提示：外周神经受压后诸如华勒氏变性、痛觉过敏等一系列反应可能有TNF〓和IL-1〓的产生，而后者的增加又会启动其它神经反应而在外周神经源性痛形成和神经退变/再生中发挥作用。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。