痛觉

We tested the possibility of selectively blocking the excitability of primary sensory nociceptor (pain-sensing) neurons by introducing the charged, membrane-impermeant lidocaine derivative QX-314 through the pore of the noxious-heat-sensitive TRPV1 channel.

一种阻断特定痛觉神经元的这种活性而又不影响其他感觉或运动神经元的方法，也许可用来创建一种目标性更强的局部麻醉方法，而这正是Binshtok等人在本期Nature上提出的一个观点。

During the painful stimulus itself, there was increased activation in the right amygdala and decreased activation in the periaqueductal gray matter and rostral anterior cingulate and prefrontal cortices, areas responsible for cortical and subcortical pain modulation, in the depressed relative to nondepressed subjects.

在痛觉刺激本身时，右杏仁体的活性增加，而导水管周围灰质的活性是下降的，且喙侧前扣带回与额前皮质，负责皮质与亚皮质疼痛调控的区域，其活性相较于非忧郁受试者来说是下降的。

During the painful stimulus itself, there was increased activation in the right amygdala and decreased activation in the periaqueductal gray matter and rostral anterior cingulate and prefrontal cortices, areas responsible for cortical and subcortical pain modulation, in the depressed relative to nondepressed subjects.

在痛觉刺激本身时，右杏仁体的活性增加，而导水管周围灰质的活性是下降的，且喙侧前扣带回与额前皮质，负责皮质与亚皮质疼痛调控的区域，其活性相较於非忧郁受试者来说是下降的。

In the noninflammatory model, 2 unilateral injections of acidic saline into the gastrocnemius muscle produced bilateral cutaneous and muscle hyperalgesia 24 hours after the second injection.

在非炎症性模型中，向单侧腓肠肌注射酸性saline液2次，在第二次注射后24小时，可产生双侧皮肤和肌肉痛觉过敏。

In thisstudy, we sought to determine whether perineural RTX preventshyperalgesia in a model of incisional pain.

本研究中，我们试图在一个切割性疼痛模型上判定神经周围应用 RTX 是否能预防痛觉过敏。

Peripherial tissue and nerve injury leads to chronic pain symptoms, including spontaneous pain, allodynia and hyperalgesia.

周围组织和神经受到损伤引起自发性疼痛、痛性感觉异常和痛觉过敏等慢性痛症状。

Thus, in polyarthritic rat, a model of chronic inflammatory pain, we demonstrated that herpes simplex irus ector mediated oerexpression of proenkephalin A in primary sensory neurons at the lumbar leel elicited both antihyperalgesic and anti-inflammatory actiities.

在一个慢性炎症性疼痛模型－多关节炎鼠上，我们证明单纯疱疹病毒媒介介导的前脑啡肽在腰水平初级神经原的过度表达引起了抗痛觉高敏和抗炎症活动。

The major SEP components of real EEG data, as well as the difference between pain and non-pain SEPs, were demonstrated to be significant with the sliding-window method.

依据上述方法分析真实EEG数据，确定了体感与痛觉诱发电位波形中具有统计学意义的成分，以及两种波形之间的显著性差异。

BACKGROUND: Spinally administered non- N -methyl-d-aspartate, but not NMDA, receptor antagonists block primary (1°) and secondary (2°) mechanical hyperalgesia and spontaneous pain after plantar incision.

背景：鞘内给予非 N-甲基-d-天冬氨酸受体拮抗剂可阻断足底切皮后原发性（1°）和继发性（2°）机械痛觉过敏和自发痛，而鞘内给予 NMDA 受体拮抗剂并无此作用。

Our observation indicates that capsaicin as a nociceptive chemical irritant can selectively activate primary afferent C-fibers to release SP and Glu from their central terminals in the superficial dorsal horn. It seems that the release of SP and Glu acting on NK-1 and NMDA receptors results secondarily in the activation of dorsal horn neurons, transmitting nociceptive information to supraspinal structures.

以上结果表明辣椒素作为一种伤害性的刺激源，可选择性兴奋C类传入纤维，引起其分布于脊髓背角浅层内的末梢大量释放SP和Glu，通过相应受体兴奋背角伤害性感受神经元，包括上行脊-丘束投射神经元，将痛觉信息传递至脑。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。