痉挛毒素

Results Women were more often affected than men(1.83:1) and 53 patients were older than 40 years. The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率 1：1.83，40岁以上发病53例，受累部位依次为眼睑58例（89.2%）、口-下颌46例（70.8%）、颈部17例（26.2%）；首发症状以眼部不适、眼睑痉挛最（42例，占64.6%），口-下颌肌张力障碍次之（17例，占26.2%）；14例行头MRI检查者8例发现脑干或基底节区病灶；口服药物治疗37例，显效4例，有效16例，无效17例；15例行肉毒毒素局部注射者显效5例，有效9例，无效1例。

The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).in part of the patients, cranial mri examination could find focus in brainstem or basal ganglia. among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. while in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1：1.83，40岁以上发病53例，受累部位依次为眼睑58例（89.2%）、口-下颌46例（70.8%）、颈部17例（26.2%）；首发症状以眼部不适、眼睑痉挛最多（42例，占64.6%），口-下颌肌张力障碍次之（17例，占26.2%）；14例行头mri检查者8例发现脑干或基底节区病灶；口服药物治疗37例，显效4例，有效16例，无效17例；15例行肉毒毒素局部注射者显效5例，有效9例，无效1例。

Objective To investigate the effect of B TX -A block by insulative needle to release the spasticity in cerebral palsy.

目的 探讨应用绝缘针注射A型肉毒毒素缓解脑瘫患儿痉挛的疗效。

Objective To investigate the optimal dose of botulinum toxic A for releasing spasticity of cerebral palsy and related factors.

目的 探讨A型肉毒毒素缓解脑瘫痉挛的适宜剂量与程度及与其他因素的关系。

Objective: To investigate the effect of botulinum toxin type A on lower limb spasticity in late spinal injury patients.

目的：评价A型肉毒毒素对晚期脊髓损伤患者下肢痉挛性疼痛和反射性挛缩状态的治疗作用。

BACKGROUND: The mechanism of spasmodic dysphonia is still unclear and lacks of confirmed diagnostic standards. Limited reports on the treatment mainly focused on botulinum toxin infiltration; recurrent laryngeal nerve section, and voice training, amongst which voice training has been considered as one of the ideal complementary therapeutic means for SD because of less side effects and complications.

背景：目前痉挛性发声障碍病因不明，缺乏统一明确的诊断标准，故治疗较为困难，关于该病的治疗有限的报道主要是喉部肉毒杆菌毒素注射，喉返神经切断，发声语言训练等，其中后一种方法无副作用及并发症，是较为理想的治疗及辅助治疗手段之一。

Objective To observe the effect of local injection with A-borulinus toxin under electromyographic guidance for treatment of spasmodic torticollis.

目的 观察肌电引导下A型肉毒毒素局部注射治疗痉挛性斜颈的疗效。

BACKGROUND: Botulinum toxin A has been applied to treat muscular convulsion by local injection and shows obvious effects in reducing muscular hypertonia with fewer side effects.

背景：采用A型肉毒毒素对痉挛肌肉的局部注射治疗已显示出既有明显降低肌肉高张力的作用，副作用又极少。

Results Women were more often affected than men(1.83:1) and 53 patients were older than 40 years. The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1：1.83，40岁以上发病53例，受累部位依次为眼睑58例（89.2%）、口-下颌46例（70.8%）、颈部17例（26.2%）；首发症状以眼部不适、眼睑痉挛最多（42例，占64.6%），口-下颌肌张力障碍次之（17例，占26.2%）；14例行头MRI检查者8例发现脑干或基底节区病灶；口服药物治疗37例，显效4例，有效16例，无效17例；15例行肉毒毒素局部注射者显效5例，有效9例，无效1例。

The involved parts were as follows: eyelid 58 cases (89.2%), mouth and mandibula 46 cases(70.8%),neck 17 cases(26.2%). The symptom at onset were blepharospasm 42 cases(64.6%) or oromandibular dystonia 17 cases(26.2%).In part of the patients, cranial MRI examination could find focus in brainstem or basal ganglia. Among 37 patients treated with oral drugs, 4 cases were almost cured, 16 cases improved and 17 cases showed no effect. While in 15 patients treated through chiostridium botulinum toxin injection, 5 were almost cured, 9 improved and 1 had no effect.

结果 男女患病比率为1：1.83，40岁以上发病53例，受累部位依次为眼睑58例（89.2%）、口-下颌46例（70.8%）、颈部17例（26.2%）；首发症状以眼部不适、眼睑痉挛最多（42例，占64.6%），口-下颌肌张力障碍次之（17例，占26.2%）；14例行头MRI检查者8例发现脑干或基底节区病灶；口服药物治疗37例，显效4例，有效16例，无效17例；15例行肉毒毒素局部注射者显效5例，有效9例，无效1例。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。