病变

Wound healing of rat skin may be arbitrarilydivided into the following stages: wound generation, suppurating in someinflammation area, growing of granulation tissue, scab formation,decrustation, and completely healing. The wound depth and the extent ofhealing also could be determined from the OCT images in the different healingtime. Healing time for the skin scald was found to be much shorter than those ofthe skin wound. Because the skin wound is serious than the skin scalds. 3 The result of using OCT to monitor the model of acetic acid gastric ulcer in rats:Results of this experiment showed that using OCT technology can identify theulcerative gastric mucosa tissues with normal tissues, make the imaging on theunder-layer of gastric mucosa tissues, and evaluate the healing period and healingquality. From the OCT images can be clearly found the acetic acid gastric ulcer.

3大鼠胃溃疡模型的OCT成像检测结果：实验结果显示利用OCT能够实现溃疡组织的成像，可显示正常胃壁组织的层次性结构，对于溃疡病变过程中可对黏膜下病变的深度与状况进行成像分析，从图像可以很明显的发现溃疡性炎症病变区域(这个区域由于散射光变弱，颜色相对比较暗)，在愈合的后期黏膜层基本愈合的状态下仍可显示黏膜下层组织的增生、未能完全愈合等病理改变。

The mice inoculated with Coxiella burnetii intrana- sally developed interstitial pneumonia,while the primary pathological changes of mice inoculated intraperitoneally are granulomas in spleen and liver.2.The pathological changes became more severe followed the dosage increasing.3.Coxiella burnetii can be detected in spleen and liver at day 2 after inoculation.the lesion became more and more serious from day 2 to day 12.The characteristic changes were observed at day 7,and recovered at day 14. 4.The reticuloendothelial system are main target of Coxiella burnetii.The pathogen was detected in cytoplasm of monocyte -macrophages of spleen, liver, lung, and endothelioid cells of blood vessel. 5. Coxiella burnetii can be found in macrophages lysosomes by electron microscopy. Most of them are round or rod, and polymorphic shape can also be observed in different size.

结果：1、通过不同感染途径的实验证实，滴鼻感染的小鼠主要表现为间质性肺炎，而腹腔注射感染小鼠则以脾脏、肝脏肉芽肿为主要病变。2、通过不同剂量的感染实验发现，随着感染Q热立克次体剂量的加大，动物病变愈加严重。3、通过感染后不同时间的动态病理学观察发现，在腹腔注射后第2d的脾和肝脏即可发现病原体，主要脏器的病理变化从第2d到第12d逐渐加重，第7d动物的病变最典型，至感染后14d动物的受损器官已开始出现修复性变化。4、 Q热立克次体主要侵害机体的网状内皮系统，在感染小鼠的肝、脾、肺和外周血管单核巨噬细胞以及血管内皮细胞胞浆中查见病原体。5、透射电镜观察可见Q热立克次体主要位于巨噬细胞吞噬溶酶体内，呈多形性，多见圆形和杆状，大小不一。

The glottal images of normal, vocal cords polypus and vocal cords nodules are sampled. The images can show the pathological position and degree intuitively. At the same time, the extracted parameters of vocal cords length and vocal cords area can provide more information to make clinical diagnosis.

对正常人和声带息肉、声带小结患者的声门图像进行了采集与分析，不仅可以直观的显示病变的部位与病变的程度，同时通过对声带长度、声带面积、病变大小等指标的测量还可为医生提供更多的诊断信息。

Results CsA clearly decreased creatinine clearance and increased urinary excretion of N-acetyl-β-D-glucosaminidase in rats as compared with those in the vehicle group. Morphologic changes consisted of vacuolization of tubular cell, expansion of the interstitium and interstitial fibrosis, hyalinization of afferent arterioles. Severity of the injury was related to the dosage of CsA. Striped interstitial fibrosis and arteriolopathy were more severe in the rats treated with CsA and low-salt diet than with CsA and normal diet.

结果 用CsA的大鼠出现尿量增多、内生肌酐清除率下降、尿N-乙酰-β-D-氨基葡萄糖苷酶排泄增多等；病理上表现为不同程度的细胞浊肿、空泡变性及灶性分布的间质纤维化和小动脉病变，随CsA剂量的增加，病变呈加重趋势；结合低钠饮食，CsA慢性肾毒性病变明显加重。

Results:MRI showed degeneration of meniscus in 16 joints,tearing in 7,changing of articular cartilage in 3,relaxing and thinning of lig.cruciatum anterius in 2 and lig.cruciatum posterius in 3,hydrarthrus in 6,changing synovial bursa and fibrous capsule each in 1.All these changes can not be seen in X-ray films.

结果：MRI显示半月板变性16个，撕裂7个；3个有关节软骨病变；前交叉韧带松弛变细2个，后交叉韧带病变3个；关节腔积液6个；滑囊、纤维囊病变各1个，而X线平片均无上述表现。

The fundus showed hypertensive retinopathy (arteriolar constriction, hemorrhage, cotton wool spots, and focal intraretinal periarteriolar transudates), hypertensive choroidopathy (exudative retinal detachment, choroidal infarction, and RPE degeneration), and hypertensive optic neuropathy.

眼底可以看到高血压视网膜病变（动脉挛缩，网膜出血，棉花状斑，以及局部网膜内动脉旁漏出物FIPTs），高血压脉络膜病变（渗出性视网膜剥离，脉络膜梗塞，以及色素网膜变性），及高血压视神经病变。

All cases were presented with cyclodialysis combined with other ocular injuries, the characteristics and surgical management were analyzed Results The major signs include vitreoretinal disorders(67.6%), lenticular injury(55.9%), obital fracture(10.8%), iridodialysis(9.0%), hyphema(5.4%).

回顾分析了2001年4月—2007年1月在本中心就诊的复杂性睫状体断离病例111例，结果在全部患者中，除睫状体断离外，伴有其他主要眼部病变包括玻璃体视网膜病变（67.6%），晶状体病变（55.9%），眶壁骨折（10.8%），虹膜根部断离（9.0%），前房积血（5.4%）。

MSCTA showed stenosis and obstruction of internal carotid artery, anterior cerebral artery and middle cerebral artery, including thirteen cases with bilateral and 6 cases with single lateral. There appeared abnormal vessels looked like smog on cerebral bottom. More than one branches of collateral artery could be seen in most of them. Sacculated aneurysm of lenticulostriate artery was shown in one patient. Five patients who were performed both MSCTA and DSA displayed similar above-mentioned vascular lesions.

MSCTA均清晰显示不同程度颈内动脉虹吸段、大脑前动脉及大脑中动脉起始段狭窄、闭塞，双侧病变者13例（68.4%），单侧病变者6例（31.6%）；脑底部见纤细迂曲的&烟雾&状异常血管网；大多可显示1支以上侧支动脉；1例显示右侧豆纹动脉囊状动脉瘤。5例同时行MSCTA与DSA者，均很好显示了上述血管病变。

When MR imaging shows thickening and enhancement of the pituitary stalk and associated leptomeningeal disease as in this case, sarcoidosis is a very strong possibility, along with meningitis, particularly fungal.

结节病为一种不明原因的炎性病变，可以影像多个系统，包括中枢神经系统，女性多见，大于10：1，黑人比白人更多见，15%病人累及中枢神经系统，5%有神经症状，脑神经功能障碍和尿崩症是最常见的神经系统结节病的临床表现，MR改变包括脑膜增厚及强化，孤立性肿块或多发性小，散在的脑膜或实质病变，此例病例中MR图像出现增厚强化的垂体蒂伴有软脑膜病变，强烈提示结节病，伴随脑膜炎尤其是真菌性，通常T2表现为低信号，虽然这些也能够在霉菌病/淋巴瘤/脑膜瘤中看到。

Results: among 69 cases, 15 cases stageⅰ, 40 cases stage ⅱand 14 cases stage ⅲ. mr can display abnormal signal of tuberculous meningitis in each stage, particularlymr enhancement scan, which present obviously miliary nodus in the brain and the thickened leptomeninges. miliary nodus of the brain was located mostly frequently at the junctional area of white and gray matter, and the thickened leptomeninges were mostly at the bottom of the brain.

结果：69例中，ⅰ期15例，ⅱ期40例，ⅲ期14例，磁共振对各期结核性脑膜炎均能显示病变，尤其是mr增强扫描，对脑内粟粒性结节及脑膜炎性病变显示最佳，粟粒性结节常位于皮髓交界区，脑膜炎性病变则以脑底部明显。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。