疼痛

The demulcent effect of HWAP-1 was investigated in inflammation ache model which based on hypodermatic injecting of formalin in rabbit and SD rats. The experiment of formalin is a normal animal model of initiative spastic ache. It is more stable and more effective than other ache models and has much more similarity to major clinical ache. With such advantages, it is applied comprehensively in many kinds of research in clinical pathology ache and clinical analgesia.

一、HWAP-1药效学研究HWAP-1在兔、SD大鼠福尔马林皮下致炎疼痛模型中的镇痛效应福尔马林皮下致炎疼痛实验作为一个标准的自发强直性疼痛动物模型，由于它具有比其它疼痛模型更稳定，更有效及与临床绝大多数疼痛具有更大的相似性等优势，故已广泛用于临床各种病理性疼痛机制研究及临床镇痛药物的研制。

Twelve patients with pancreatic cancer and intractable pain in their advanced stage were included. All of them received general anesthesia when performing celioscopic thoracic sympathetic ganglionectomy. Result: Half of the patients who suffered serious pain before operation felt no pain during early postoperative course and hadnt got a relapse at a follow up of 4—6 months.

选择晚期胰腺癌疼痛的患者，12例均在全麻双腔支气管插管麻醉下，经腹腔镜行胸腔内脏交感神经节切断术，结果：6例术前重度疼痛者，术后疼痛完全消失，随访 4~6月无复发，6例极度疼痛者，术后8月内完全无痛。

Used the GA to Jingo three point, we have treated 60 cases CS patient, healed 22 cases, obvious effects 21 cases, effects 13 cases, no effects 4 cases, whole effects rate is 93. 33%, GA group's therapeutic effects is significance better than that of controlled group, we measure CS patient's pain by the Shortform McGill Questionnaire, found that GA has a better effects of analgesia than that of contraction, GA can stop pain in three course. After analysis the relationship between age and clinical therapeutic effects, we found that both of the two therapeutic method have a good effects for the young, but a bad effects for the old.

应用电针颈三针为主，配以辨证取穴，经治60例CS患者，痊愈22例，显效21例，有效13例，无效4例，总有效率93.33％，疗效显著优于牵引对照组；应用简化McGill疼痛询问量表，对CS患者疼痛进行客观量化，发现经三个疗程的治疗，电针组对疼痛的改善明显优于对照组，电针组三个疗程对疼痛均有显著改善，第一疗程对疼痛的改善显著优于对照组；经过对两组病例不同年龄段与疗效的关系分析，发现两种疗法均是对年轻者疗效显著，对年老者疗效较差。

Back pain can be divided into neck pain, upper back pain, lower back pain or lumbago, and coccydynia.

背部疼痛的分类：背部疼痛可以分为颈部疼痛，上背部疼痛，下背部或腰痛和尾骨疼痛。

According to visual algetic mimic scale, 3 patients suffered moderate pain and 7 cases suffered severe pain.

用视觉模拟疼痛评分法评价疼痛程度，中度疼痛3例，重度疼痛7例。

The results showed that (1) the most and average painful intensity had significant improvement in Experimental group I,(2) the total measured scales of painful disturbance had significant improvement in Experimental group I,(3) the total measured scales of painful disturbance had significant improvement in Experimental group II,(4) the negative effect of pain belief had significant improvement in two Experimental group,(5) the depressively emotional disturbance had significant improvement in Experimental group II,(6) relaxation training had immediate effects on improving pain, anxiety and depression.

研究结果发现：(1)疼痛教育组之最重疼痛强度及平均疼痛强度有显著改善(2)疼痛教育组之疼痛干扰整体量表具有显著改善(3)疼痛教育放松训练组之疼痛干扰整体量表具有显著改善(4)疼痛教育组之疼痛及麻醉性止痛药信念有显著改善(5)疼痛教育加放松训练组之疼痛及麻醉性止痛药信念有显著改善(6)疼痛教育加放松训练组之忧郁情绪困扰有显著改善(7)疼痛教育放松训练组之放松训练对於改善疼痛、焦虑及忧郁之情绪状态有立即性效果。

The study expressed giving correct pain education could improve the pain intensity, pain disturbance, depression emotion and negative effect of pain belief of cancer patients, and addition relaxation training could ameliorate depressively emotional disturbance and could have improving immediate effects on pain, anxiety and depression.

研究显示给与正确之疼痛教育可以改善癌症病患疼痛强度、疼痛干扰、忧郁情绪及疼痛与麻醉性止痛药信念，而增加放松训练能减缓忧郁情绪困扰且对於疼痛、焦虑及忧郁之情绪状态有立即性效果。

There were no significant differences for the firing rates in the site of contralateral TNC neurons among during pre-CSD,CSD,and post-CSD (P＞0.05).For flunarizine group,the firing rates in the site of ipsilateral TNC neurons during pre-CSD were higher as compared with during CSD(P＜0.05).2.1 There were statistical differences on palasma levels of CGRP and SP among the three groups(P＜0.05).The levels of CGRP and SP in CSD group were higher than control group(P＜0.05).No significant differences on the levels of CGRP and SP in ipsilateral trigeminal ganglia were found among the three groups(P＞0.05).2 The number of neurons with positive CGRP and SP immunoreactivity was statistically different in right-sided trigeminal ganglia among the three groups (P＜0.05).The number in fight-sided trigeminal ganglia in CSD group was higher as compared with control group(P＜0.05).The number in right-sided trigeminal ganglia was statistically higher than that in left-sided trigeminal ganglion in CSD group(P＜0.05).3.1 Altered ReHo in ipsilateral pons and other brain regions response to pain such as basal nuclei,thalamus,cingulated gyms and prefrontal cortex was detected during the acute spontaneous attack as compared with during headache remission(P＜0.05,corrected by Monte Carlo simulation). 2 Positive functional connectivity was detected between ipsilateral pons and other brain regions related to pain within pain state and within non-pain state (P＜0.05,corrected by false discovery rate,FDR).Increased functional correlation between ipsilateral pons and other pain-related brain regions such as ipsilateral prefrontal cortex and contralateral subcallosal gyrus was detected during the acute spontaneous attack as compared with during headache remission(P＜0.05,corrected by Monte Carlo simulation).

结果1。对照组未发现CSD；同侧TNC放电频率，CSD中＞CSD后＞CSD前P＜0.05对侧TNC放电频率，CSD前、中、后无统计学差异(P＞0.05氟桂利嗪组同侧TNC放电频率，CSD前＞CSD中(P＜0.05)，CSD前与CSD后及CSD中与CSD后之间无统计学差异(P＞0.05)。2.1关于放免测定，各组血浆CGRP、SP水平有统计学差异(P＜0.05)，CSD组高于对照组(P＜0.05)，CSD组与氟桂利嗪组、对照组与氟桂利嗪组之间均无统计学差异P＞0.05各组之间同侧三叉神经节中CGRP、SP水平未见变化(P＞0.05.2关于免疫组化研究，右侧三叉神经节CGRP、SP免疫阳性细胞数三组之间有统计学差异(P＜0.05)，多重两两比较结果CSD组大于对照组(P＜0.05)，CSD组与氟桂利嗪组之间、对照组与氟桂利嗪组之间无统计学差异P＞0.05左侧三叉神经节CGRP、SP免疫阳性细胞数三组之间无统计学差异(P＞0.05CSD组中右侧三叉神经节CGRP、SP免疫反应阳性细胞数大于左侧(P＜0.05)。3.1局部一致性分析发现两组患者头痛疼痛状态较非疼痛状态脑活动发生变化的脑区有同侧脑桥以及其他疼痛相关脑区如基底节区、丘脑、扣带回、前额叶皮层等(P＜0.05，蒙特卡罗模拟校正)。2功能连接分析发现疼痛状态与非疼痛状态下主要疼痛相关脑区均与同侧脑桥有功能联系P＜0.05，false discovery rate，FDR校正疼痛状态与非疼痛状态比较，同侧前额叶皮层、对侧胼胝下回等疼痛相关脑区与同侧脑桥之间功能联系增强(P＜0.05，蒙特卡罗模拟校正。

Data analysise indicates that anxiety , dumps and so on are the main components of chronic-pain of old ages; faith and self- anticipation affect the sense and therapy of chronic-pain of old ages; the sense of going down the drain and stimulation- monotony intensify the chronic-pain of old ages; reasonless attribution affect the chronic-pain cognise of old ages. old ages adopt different strategies such as seeking help, cowering, and positive dealing. Hence the senses and therapy results of chronic-pain of old ages are different.

资料归类分析提示：焦虑、抑郁等情绪体验是老年人慢性疼痛的重要组成部分；信念及自我预期影响着老人慢性疼痛的感受和治疗；被抛弃感、刺激贫乏等导致的孤独感是老人慢性疼痛的强化剂；不合理的归因影响着老人对疼痛的认知；老人面对慢性疼痛，采用了求助、退缩、积极应对等不同的应付策略，由此导致疼痛的感受和疼痛治疗效果也是不同的。

The results showed that (1) the intervention of preoperative pain education resulted in statistically significant reductions of worst pain intensity after surgery in experimental group compared to control group,(2) subjects in the experimental group experienced statistically significant reductions of pain interference in general activity, mood, and sleep, compared to control subjects,(3) the misbeliefs about pain management were significantly improved after surgery in experimental group compared to control group,(4) no statistically significant differences were found in the score of satisfaction with pain management, or amount of analgesics between the two groups.

研究结果显示：（1）实验组接受手术前疼痛卫教介入措施后，手术后最剧烈疼痛强度低於控制组达统计上显著差异。（2）实验组手术后疼痛对日常生活、情绪及睡眠的干扰程度低於控制组，达统计上显著差异。（3）手术后实验组错误疼痛处置信念的改善程度，与控制组达统计上显著差异。（4）手术后的疼痛处置满意度及止痛药使用剂量，两组间无统计上显著差异。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。