疱疹

Grouping.Grouping is acharacteristic of dermatitis herpetiformis,herpes simplex,herpes zoster,and late syphilitic eruptions.Small lesions arranged around alarge one are said to be in acorymbose arrangement.Concentric annular lesions are typical of borderline leprosy and erythema multiforme.These are sometimes said to be in acockade pattern,like the tricolor cockade hats worn by French revolutionists.Flea and other arthropod bites are usually grouped and linear(breakfast-lunch-and-dinner sign).Grouped lesions of various sizes may be termed agminated.

群集群集是疱疹样皮炎、单纯疱疹、带状疱疹和梅毒疹的特点小的皮损围绕大的皮损排列称为伞状排列同心圆形皮损是中间界线类麻风和多形红斑的典型皮损这种皮损有时被描述为帽章的形式，就象法国革命者所戴三色帽章跳蚤和其他节肢动物的咬痕常呈群集或线性分布各种大小的皮损聚集在一起术语称为"簇集"

Halford joined SIU's faculty in 2007, but has been researching the herpes simplex virus since 1992, first focusing on HSV-1, which causes cold sores and sometimes leads to genital herpes.

哈尔福德于2007年加入萧的教师，但自1992年以来一直在研究单纯疱疹病毒，首先侧重于单纯疱疹病毒1，这会导致唇疱疹，有时会导致生殖器疱疹。

Methods: Mice were inoculated intracerebrally with herpes simplex virus type1(HSV-1) to form herpes simplex encephalitis. MMP-9 gelatinolytic activity was assessedby zymography from brain tissues 3 days and 7 days after HSV-1 infected.

第一部分单纯疱疹病毒性脑炎相关病理机制的研究实验一MMP-9在单纯疱疹病毒性脑炎中的表达及对血脑屏障的影响目的：研究单纯疱疹病毒感染小鼠脑组织后MMP-9的变化及对血脑屏障通透性的影响。

objective to discover the therapeutic effect on herpes zoster treated by orpiment and earthworm in compound tinclura.methods oet was externally used on 43 cases in treatment group,phthiobuzonum liniment and 1% chinese goldthread calamine lotion were externally used on 41 cases in control group,and in addtion the two groups were intravenous injected by drip acyclovir 500mg qd.results the comparison of observation index between the two groups had diversity on significance of statistics(p＜0.01 or p＜0.05).conclusion oet external used on herpes zoster patient get a better curative effect.

目的 观察复方雄黄地龙酊治疗带状疱疹的疗效。方法治疗组43例外用oet，而对照组41例外用酞丁安搽剂和1%黄连炉甘石洗剂，两组均静滴阿昔洛韦500mg，每日1次。结果两组在观察指标（止痛、止疱、结痂、痊愈、后遗神经痛发生率）的比较中，差异有统计学意义（p＜0.01或p＜0.05）。结论外用复方雄黄地龙酊治疗带状疱疹，效果良好。复方雄黄地龙酊；带状疱疹

Herpes simplex virus, the etiological agent of many human diseases, belongs to a subfamily of Herpesviridae.

单纯疱疹病毒属于疱疹病毒科中的α疱疹病毒亚科，是人类多种疾病的病原体。

Grouping is a characteristic of dermatitis herpetiformis, herpes simplex, herpes zoster, and late syphilitic eruptions.

群集。群集是疱疹样皮炎、单纯疱疹、带状疱疹和梅毒疹的特点。

For most viruses,there is aneed for antimicrobials that target unique viral molecular properties.Acycloviris one such drug.It is activated into ahuman herpesvirusDNA polymerase inhibitor exclusively by HHV kinases and,thus,does not suppress other viruses.Here,we show that ACV suppresses HIV-1in HHV-coinfected human tissues,but not in HHV-free tissue or cell cultures.However,addition of HHV-6-infected cells renders these cultures sensitive to anti-HIV ACV activity.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.Indeed,an ACV monophosphorylated prodrug bypasses the HHV requirement for HIV suppression.Furthermore,phosphorylated ACV directly inhibits HIV-1reverse transcriptase,terminating DNA chain elongation,and can trap RT at the termination site.These data suggest that ACV anti-HIV-1activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1RT inhibitors.

对大多数病毒而言，都需要有针对其分子特性的靶向杀毒剂阿昔洛韦就是这样一种靶向药物在人疱疹病毒酶的特定作用下，阿昔洛韦被激活成为人疱疹病毒DNA聚合酶抑制剂，因此不能再抑制其它的病毒我们的研究发现阿昔洛韦在共感染人疱疹病毒的组织中可以抑制HIV-1，但在无人疱疹病毒感染的组织或细胞中无此作用然而，加入人疱疹病毒-6感染的细胞却使得其对抗HIV的阿昔洛韦变得敏感我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化实际上，单磷酸化的阿昔洛韦前体药物无需人疱疹病毒的参与即可抑制HIV此外，磷酸化的阿昔洛韦能直接抑制HIV-1逆转录酶，将其阻止在终止位点，从而终止DNA链的延长这些结果提示阿昔洛韦的抗HIV-1活性决定了艾滋病病毒/人疱疹病毒共感染的患者对阿昔洛韦的治疗反应，也有助于开发新的HIV-1逆转录酶抑制剂

Like other alpha herpesvirus such as herpes simplex virus type I, varicella-zoster virus and bovine herpesvirus type I, PRV also has some typical characteristics of alpha herpesvirus, including latency and neurotropism.

与同属α—疱疹病毒亚科的人单纯疱疹病毒、水痘-带状疱疹病毒和牛疱疹病毒Ⅰ型等一样，PRV具有潜伏感染和神经嗜性等α—疱疹病毒的典型特征。

Genital HSV-2 infection almost always recurs frequently with or without symptoms whereas HSV-1 genital herpes reactivates infrequently.

感染几率的大小取决于性服务提供者是否患有口腔和唇部疱疹，以及口腔和唇部疱疹病毒（HSV-1）当时是否在发作期；如果她当时有正在发作期的口腔和唇部疱疹溃疡或水泡，那么感染生殖器疱疹的概率会相当大。

Methods Using the well-conserved regions of the DNA polymerase gene in human herpesviruses,we synthesized two pairs of primer,including one pair of primer designed to amplify herpes simplex virus type 1 and 2,Epstein-Barr virus and cytomegalovirus,another pair of primer to varicella-zoster virus and human herpesvirus 6 by PCR.

2 0 0 2年 1～ 12月浙江大学儿童医院在疱疹类病毒高度同源序列DNA多聚酶基因中设计两对通用引物，该引物能同时扩增单纯疱疹病毒Ⅰ型与Ⅱ型、爱泼斯坦—马尔病毒、人巨细胞病毒、水痘带状疱疹病毒和人类疱疹病毒 6型(HHV6) 6种病毒。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。