疫苗

Restrictive changes of TCR Vp repertoire and clonal expanded T cells could be found in peripheral blood T cells from patients with T-ALL. However, the clonal expanded T cells' property (clonal expansion leukemic cells or leukemia antigen-specific expansion T cells) should be further characterized. It may play a certain role on detection of minimal residual disease and design of anti-leukemia idiotypic vaccine. The dominant utilization of TCR VjJ repertoire could be found in peripheral blood T cells from patients with B-ALL, meanwhile clonal expansive T cells were existed. It may be a feature of the host immune response for leukemia-associated antigen. The clonal expansive tendency of T cells in V021 and VP23 subfamilies was rather obvious, which may be correlated with certain malignant B-cell clone. The CDR3 sequences of monoclonal expansive T cell in T cell strains were different, which was the base of developing DNA vaccine.

T-ALL患者外周血T细胞的TCR Vβ谱系出现限制性改变，均可检测到克隆性增殖T细胞，尚需进一步鉴定其性质(肿瘤性或抗原特异性增殖)，对于研究微小残留病变检测和设计抗白血病独特型疫苗均有一定的意义。B-ALL病人外周血T细胞的TCR Vβ谱系呈现优势利用的特点，并存在克隆性增殖的T细胞，这可能是机体对白血病相关抗原产生的特异性免疫反应；Vβ21和Vβ23亚家族T细胞发生克隆增殖改变的趋向性比较明显，可能与B-ALL相关抗原刺激有关。T细胞株中检测到的肿瘤克隆其CDR3序列具有高度的特异性，是构建DNA疫苗的基础。

Dr. Joshi emphasized:"We should continue vaccinating all children, but continue our quest to find a more effective influenza vaccine."

Joshi医师强调，我们应该继续对所有儿童施打疫苗，但要继续寻找更有效的疫苗。

Unlike Dr Kappe's vaccine, this one does not rely on injecting whole, attenuated parasites.

与凯普博士的疫苗不同，阿朗索的疫苗并不依赖于注射完全且毒性减少的寄生虫。

Methods Activate groups A and C meningococcal polysaccharide with cyanogens bromide and prepare into MenAPS-ADH and MenCPS-ADH derivatives by reacting with 1, 6-adipic acid dihydrazine. Mix MenAPS-ADH and MenCPS-ADH derivatives with purified tetanus toxoid at a certain mass ratio, then add l-ethyl-3(3-dimethylaminopropyl)-carbodiimide to prepare bulks of MenAPS-TT and MenCPS-TT conjugates respectively. Mix the two bulks at a certain ratio, add stabilizer and lyophilize to prepare group A+C meningococcal polysaccharide conjugate vaccine.

A群和C群脑膜炎球菌多糖在溴化氰的活化下，以1，6己二酰肼作为连接子，与精制破伤风类毒素在碳二亚胺作用下结合，再按一定的比例将两者混合，制成A+C群脑膜炎球菌多糖结合疫苗原液，加保护剂冻干后，制成A+C群脑膜炎球菌多糖结合疫苗。

Tenella sprayed on the litter for the challenge immnnity for more than 50 con- secutive days, while feeding medicated feeds contained each of 4 anticoccidials at various madi- cation programs in 6 groups.

鸡球虫病同许多传染病一样，化疗和疫苗免疫是两个主要的防治措施，在疫苗免疫的某些关键性技术尚未突破之前，目前仍主要靠药物防治。

Resultsthe measl es immunization ra te of first dose and second dose were 86.2% and 60.4% respectively, the type(ele mentary school/kindergarten), school attribute(public/private), students' age a nd origin, parents' educational level were related to the immunization of secon d dose measles.

结果 深圳市入学、入园新生1剂次和2剂次麻疹疫苗接种率分别为86.2％和60.4％。影响学生麻疹2剂次接种的主要因素包括学校类别、学校属性、学生年龄、户籍、父亲及母亲的文化程度和地区差别。结论深圳市入学学生2剂次麻疹疫苗接种率不高。

David Ho: Merk's Ad5 vaccine is the failure of the world have a great impact, and this is a T cell vaccine idea of the challenge.

何大一：Merk公司Ad5疫苗的失败是对全球有很大的影响的，这是对T细胞疫苗思路的挑战。

Merk drug company vaccines admits injecting cancer viruses into their vaccines and we have the proof on video for you to watch.

标记制药公司的疫苗坦承注射癌症病毒纳入其疫苗，而我们也有证据证明对音乐录影带，你可看。

Researchers heiled to studies of an experimental AIDS vaccine from the drug company Merk early result show that the vaccine not only fail to protect, it appeared to put some people at higher risk of infection.

研究人员暂停了默克公司的两项AIDS的疫苗实验。其前期结果表明疫苗不仅没有保护作用，相反会增加一些人感染的危险性。

Methods:Prepared multilaminar liposome vaccine by film evaporaqtion combined with lyophilization; Immunized BALB/c mice with the obtained liposomeencapsulated influenza split vaccine and the routine influenza split vaccine, serum antibodies were assayed on weeks 213 by the haemagglutinationinhibition test and ELISA, the HI test for the special antiHA antigen and the ELISA test for the IgG. Protective immunity against intranasal virus challenge was determined at 12 weeks postvaccination.

采用薄膜法与冷冻干燥法相结合的方法制得多层脂质体；用制得的脂质体流感疫苗和普通疫苗分别免疫小鼠，用血凝抑制实验和酶联免疫吸附试验对免后2～13周的小鼠血清的抗体水平进行检测，HI检测其特异性抗体，ELISA检测IgG抗体水平并对小鼠的保护效率进行检测。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。