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Objective To analyze the randomly amplified polymorphic DNA bands of Anopheles dirus and A.stephensi,and the relationship between the host genotype the susceptibility of anopheline mosquitoes to Plasmodium yoelii.

目的分析对约氏疟原虫不易感的大劣按蚊和易感的斯氏按蚊基因组RAPD谱带并测序,探讨媒介按蚊基因型与疟原虫基因型间的相互关系。

The most convincing evidence of this view came from Aotus monkey trial in which immunization of the monkeys with native PtMSP 1 isolated from cultured falciparum malaria parasites provided partial to complete protection against the challenge of homologious strain.

用纯化的MSP1天然蛋白免疫的夜猴能部分或完全保护后来同种疟原虫的攻击感染。MSP1特异单抗或多抗能在体外有效抑制疟原虫的生长。

Objective: To evaluate the protective ability of vaccinia virus vectored multi-epito pe live vaccine candidate for plasmodium falciparumin experimental anim als, and to lay foundation for next testing on Aotus sp.

摘 要 目的:探讨恶性疟原虫保护性抗原复合基因-痘苗病毒重组活疫苗候选株在实验动物的抗疟原虫攻击能力,为下一步进入夜猴及人体试验奠定基础。

Daphnetin lowered SOD activity and decreased DNA synthesis of P. f in vitro.

结论在体外瑞香素可显著降低疟原虫SOD活性,并影响滋养体阶段疟原虫的DNA合成。

Methods The effect of daphnetin, daphnetin-Fe complex and desferrioxamine B on SOD activity of P. falciparum FOCI in vitro was determined with a SOD test-kit.

方法在恶性疟原虫FCC1株体外培养体系中,以SOD试剂盒检测瑞香素、瑞香素铁盐及去铁胺对疟原虫SOD活性的影响。

The pre erythrocytic stage vaccines aim to prevent the development of all clinical symptoms and subsequent malaria transmission. Erythrocytic stage vaccine designed aims to induce antibodies that prevent invasion and infection of erythrocytes, to reduce morbidity and mortality by decreasing the parasite load.

作用于红细胞前期的疟疾疫苗主要是抑制疟疾的临床发作,控制疟疾的传播;作用于红细胞期的疟疾疫苗诱导宿主体液免疫系统,产生特异性抗体,抑制疟原虫侵入和感染红细胞,达到减少疟原虫虫荷,降低疟疾的发病率和死亡率。

All P. falciparum parasites alive today appear to derive from an individual example of P. reichenowi .

现存的所有恶性疟原虫是由亚种疟原虫的某个个体衍生而来。

These results indicate that as a main effector, specific IgG play a key role against re-infected with homologous Plasmodium but haven't protection against re infected with heterogenic Plasmodium.

特异性IgG抗体可在宿主抗同源疟原虫再感染中发挥着重要作用,而对异种疟原虫再感染无保护性。

In order to reach this goal,the primary basic research work is to clone,evaluate and analyse the function of the genes that support or impact the development of malaria parasites in the mosquito vecter and the study on the mechanisms of innative immune defence responses against Plasmodium infection.

于上世纪九十年代,WHO提出了基因操纵蚊媒的新策略,而寻找支持或抑制疟原虫在蚊体内发育的相关基因,克隆、鉴定及分析其功能,以及研究按蚊抗疟原虫感染的先天性免疫反应机制是实现这一策略的重要前提。

When she jabs her proboscis into a person's epidermis to drink blood, she sprays the bite area with saliva that serves as an anticoagulant. If her last victim had malaria, that saliva will contain one-celled malaria parasites called plasmodia, a couple of dozen of which can enter the human bloodstream. But it only takes one to kill a person.

当按蚊的雌蚊猛刺进人的皮肤吸血时,还会喷射抗凝剂,假如它叮咬的是患有疟疾的病人,那么雌蚊也就把疟原虫吸进它的体内,然后她又去叮咬其它的人,又把雌蚊体内的疟原虫传播到另外的人造成新的疟疾病人。

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