疏

In the current study, a series of cationic α-helical peptides of 20 a.a. were designed and synthesized based on four structural parameters, including charge, polar angle, hydrophobicity, and hydrophobic moment. Several methods were performed to describe the influence of these parameters on the antimicrobial and hemolytic activity, and on the permeabilizing effect on model membranes. The potential of these parameters to increase the antibacterial activity and to improve the prokaryotic selectivity is assessed.

本实验利用自行设计合成的人工抗菌胜肽当模型，固定长度为 20 个胺基酸，改变其电荷、极性角度、疏水性及疏水性矩等四种结构特性，并利用其对各种不同病原菌之抗菌活性及对兔子红血球细胞的溶血活性来研究其结构特性的改变对其抗菌活性、选择性及微脂体膜的渗透性之影响，以期望改变结构参数能增加抗菌活性及对原核的选择性。

For a peptide to act as part of the host defense system or to be of pharmaceutical interest, high antimicrobial activity must be combined by low hemolytic activity. Our results indicated that the antimicrobial activity increased with increasing charge and polar angle, with charge of ＋4 and polar angle of 140° exhibiting the highest antibacterial and membrane permeabilizing activity. Higher hydrophobicity and hydrophobic moment correlated with increased hemolytic activity, thus decreasing selectivity dramatically.

胜肽要扮演宿主免疫机制的一部分或要成为新型态的抗生素不仅要有强大的抗菌活性还需要有高度的选择性，由本实验的结果发现，当抗菌胜肽的正电荷及极性角度增加时，胜肽之抗菌活性会随之增加，当抗菌胜肽的电荷为＋4而极性角度为 140°时，胜肽有最强之抗菌能力及膜渗透活性；而随著胜肽疏水性以及疏水性矩的增加，会增加溶血活性，结果反而降低了抗菌胜肽的选择性。

Quantify the Relevance Hydrophobicity in Protein Structure : The general expectation is that hydrophobic aminoacids are in the core of proteins, while polar aminoacids are on the surface.

量化蛋白质结构的参比疏水性：一般认为，疏水性氨基酸在蛋白质的核中，而极性氨基酸在表面。

Ionic attraction between the –SO3- residues on the column and the charged functional groups on the amino acid residues and hydrophobic interactions between amino acid side chains and the strongly hydrophobic bead of polystyrene resin.

柱子上的–SO3-与氨基酸残基上的带电官能团之间的离子吸引和氨基酸侧链与高度疏水的聚苯乙烯树脂珠之间的疏水相互作用。

It is found that the existence of HMPAM can affect the adsolubilization ability of the surfactants pronouncedly. The longer the alkyl chain of the surfactant is the ability of the adsolubilization of the surfactant is more enhanced.

当疏水性聚合物-疏水改性聚丙烯酰胺，和表面活性剂的混合物共同对2-萘酚进行吸附增溶时发现：表面活性剂的烷基链越长，受HMPAM存在的影响其吸附增溶能力增加越明显。

Shu Shu in the rain and fog, I saw a huge painted screen in front of an oncoming ship, the visitors to stir, finally, etc. to the Lijiang River on the "nine horse painting mountains."

疏疏的雨雾中，只见前面有一幅巨大的画屏迎面而来，船上的游人一阵骚动，终于等来了漓江上的这"九马画山"。

Methods The antibody of Borrelia burgdoferi in the crowd serum was detected by immunofluorescence, and the spirochete DNA was tested with PCR.

情况。方法人群血清伯氏疏螺旋体抗体的检测采用免疫荧光法，以聚合酶链反应检测伯氏疏螺旋体DNA。

The dredge valve is a specific item of energy saving equipment in steam heating system .

疏水器是蒸汽供热系统中一种特殊的节能设备，介绍了在生产中如何正确地选择、安装、使用和推广疏水器。

In the steam pipe jacket trap, set a competent Road, close to the radius of the condensate pipeline in the water collecting well, and then use the small tubes lead to the trap.

在蒸汽管道上装疏水阀，主管道要设一个接近主管道半径的凝结水集水井，然后再用小管引至疏水阀。

The steam pipe jacket trap, set a competent Road, close to the radius of the condensate pipeline in the water collecting well, and then use a small tube lead to the trap.

在蒸汽管道上装疏水阀， ISO国际标准阀门主管道要设一个接近主管道半径的凝结水集水井，然后再用小管引至疏水阀。

The concept of equivalent rotationally rigidity is offered and the formula of rotationally rigidity is obtained.

主要做了如下几个方面的工作：对伸臂位于顶部的单层框架—筒体模型进行分析，提出了等效转动约束的概念和转动约束刚度的表达式。

Male cats normally do not need aftercare with the exception of the night after the anesthetic.

男猫通常不需要善后除了晚上的麻醉。