甾体

In the first chapter, Barton reaction of C〓-hydroxy was studied.

论文第二部分分两章，第一章主要考察了甾体C〓-羟基的Barton反应，期望通过C〓-羟基的Barton反应进行18-甲基的官能团化。

From 30 different strains of fungi 11 strains of Beauveria bassiana and 1 strain of Aspergillus fumigatu were selected out, according to their ability to hydroxylate androst-4-ene-3, 17-dione by TLC for the initial screening.

本实验通过对30株真菌转化4AD甾体类化合物能力的筛选，初筛获得对4AD具有转化能力的球孢白僵菌11株，烟曲霉1株。

Objective To investigate whether novel isoflavone and steroid derivatives have better antitumor activity.

目的 研究改构后的异黄酮及甾体类化合物是否具较好的体外抗细胞增殖的活性。

The present doctoral dissertation was carried out to study the chemical constituents isolated from stems of two medicinal schisandraceous plants.34 compounds were isolated from the ethanol extracts of the stems S.henryi collected in the Jiangxi province by various column chromatographies.27 of them were identified on the basis of spectral analysis.There are 18 lignans,(including 5 dibenzocyclooctadienes,6 aryltetralins,2 tetrahydrofurans,3 diarylbutanes,2 other lignans),3 flavanols,2 glyceroesters,1 naphthoquinone,1 xanthine and 2 steroids,of which 6 compounds were new compounds,and 7 compounds were isolated from this family for the first time.

采用多种色谱技术进行分离纯化，从翼梗五味子藤茎的乙醇提取物中分离到34个化合物，综合运用现代波谱学技术鉴定了27个化合物，包括木脂素类化合物18个(其中联苯环辛烯类木脂素5个，芳基四氢萘类木脂素6个，四氢呋喃类木脂素2个，二芳基丁烷类3个，其他类型木脂素2个)，黄烷醇类化合物3个，甘油酯类化合物2个，萘醌类化合物1个，黄嘌呤类化合物1个，甾体类化合物2个，其中，5个为新化合物，7个为本科首次报道。

Methods Using transurethral electrovaporation of prostate combined with orchiectomy emasculation and non-steroidal antiandrogen,total androgen blockade.

采用经尿道前列腺汽化电切术，结合睾丸切除去势术和联合非甾体类抗雄激素，作雄激素阻断治疗。

First Total Synthesis of OSW-1, an Exceptionally Potent Antitumor Saponin OSW-1, an acylated disaccharide steroidal saponin isolated by Sashida in 1992 from a plantnamed Ornithogalum saundersiae without any medicinal background, was one of the most potent antitumor agent to date with the cytotoxicity activity as 100 times potent as many other anticancer drugsclinically used.

一、极强抗癌活性皂甙——虎眼万年青皂甙(OSW-1)的首次全合成：虎眼万年青皂甙OSW-1是一个新近由日本化学家从非药用植物Ornithogalumsaundersiae中分离出来的具有极强抗癌活性的酰化二糖甾体皂甙，它对多种癌细胞的毒性比临床用药高100倍以上。

First Total Synthesis of OSW-1, an Exceptionally Potent Antitumor SaponinOSW-1, an acylated disaccharide steroidal saponin isolated by Sashida in 1992 from a plant named Ornithogalum saundersiae without any medicinal background, was one of the most potent antitumor agents to date with the cytotoxicity activity as 100 times potent as many other anticancer drugs clinically used.

虎眼万年青皂甙 OSW-1 是一个新近由日本化学家从非药用植物 Ornithogalum saundersiae 中分离出来的具有极强抗癌活性的酰化二糖甾体皂甙，它对多种癌细胞的毒性比临床用药高 100 倍以上。

Objective Some pentacyclic steroidal analogues with 3-hydroxy-5-ene moiety have been synthesized to evaluate inhibition of VEGF in breast cancer cells.

目的 设计合成一系列具有3-羟基－5-烯骨架的五环甾体骨架衍生物，并测试其抑制乳腺癌细胞新血管生成的活性的抑制作用。

ResultsOnly five species of Pholidota genus were studied and 41 compounds were isolated and characterized including 9,10dihydrophenanthrenes, phenanthraquinone, bibenzyls, stilbenes, triterpenoids, phenyl propanoids, lignans, sterols and aliphatic compounds, and some plants and compounds exhibited analgesic, antioxidant, anticancer and NO production inhibitory activities.

结果目前石仙桃属植物研究所涉及的种类仅5种，从该属植物中分离出化学成分41种，包括9， 10二氢菲、菲醌、联苄、二苯乙烯、三萜、苯丙素、木脂素、甾体和脂肪族等结构类型。一些种类所含成分在镇痛、抗氧化、抗癌、抑制NO生成等方面显示了较好的活性。

Methods 132 neurosurgical patients undergoing selective subfrontal craniotomy without the pain of the incision of scalp were involved. The onset, severity, and characters of the neuralgia were recorded.

132例择期行冠状切口经额下入路的神经外科患者，排除切口局部疼痛后记录神经痛的发生时间、程度和性质；所有拟诊为术后神经痛的患者首先应用非甾体类消炎镇痛药物口服及脱水治疗，对经药物治疗后疼痛视觉模拟评分仍高于7分的患者行类固醇激素神经阻滞疗法。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。