甾体

Objective: The signs and symptoms of ankylosing spondylitis respond inadequately to nonsteroidal antiinflammatory drugs, corticosteroids, and disease modifying antirheumatic drugs in quite a number of patients.

目的：许多强直性脊柱炎患者的症状和体征对非甾体类抗炎药物、皮质类固醇、缓解病情抗风湿药物的治疗反应不佳。

It polar solvent a peroxyorganic acid is used to oxidate steroid sapogenin to obtain steroid lactone with C22 and 3 methyl-gamma-butyrolactone.

在极性溶剂中用过氧有机酸氧化甾体皂甙元，得到具有22碳的甾体内酯和3－甲基－γ－丁内酯。

Whenpyridine was used as reductive decomposing agent, the expecting cholest-4-en-3,6-dione-22-al was obtained. However, when Zn/HOAc was used to decomposethe ozonide, C-4,5 double bond was further reduced to give cholest-3,6-dione-22-al as main product. 2 For the side-chain construction of compound (1), the solid-liquid phase-transfer Wittig reaction was used. When (3-methyl-2-oxobutyl)-triphenylarsonium bromide was used as reagent, the reaction can be carried out inmild reaction condition and the yield is higher than that when phosphorane wasused.

但使用Zn／HOAc作为分解剂时，却得到其氢化产物胆甾-3， 6-二酮-22-醛；2在甾体支链引入过程中，采用固-液相转移Wittig反应的方法，用(3-甲基)-2-氧丁基三苯基溴化胂作为试剂，反应在非常温和的条件下便可完成，而且产率比传统采用膦烷的方法更高；3在对某些甾酮化合物的选择性还原反应研究时，发现在〓还原体系中，当加入某些金属离子后，反应有更好的区域选择性和立体选择性。

Its root contains a variety of steroidal saponins,- sitosterol, Bianchi acid, glucose, and vitamin A and other diverse material.

其块根含有多种甾体皂苷、-谷甾醇、安基酸、葡萄糖、和维生素A等多样物质。

It is suggested that ceramide may serve as an important signaling molecule mediating certain ovarian processes, such as luteal regression.

结果提示，神经酰胺可能通过调节甾体激素生成和细胞凋亡而作为一种重要的信息分子参与黄体退化等卵巢的生理过程。

From Whitmania pigra 10 compounds were isolated and structurally elucidated based on the spectral data, 9 of them were the firstly isolated from this species. They are choles-4-ene-3-one, uracil, succinic acid, hypoxanthine,xanthine, octadecanoic and 2 polyhydroxy-saturated fatty acid.

五对宽体金线蛭的化学成分进行了提取、分离、鉴定，从中分得10个化合物，其中9个为首次从该动物中分得，包括1个为甾体化合物胆甾-4-烯-3-酮、2个多羟基脂肪酸、琥珀酸、尿嘧啶、黄嘌呤、次黄嘌呤、脲苷、十八碳酸等。

ObjectiveTo study the clean production technology of diosgenin. MethodsThe diosgenin was extracted by prefermentation,separation, enzymic hydrolysis, prefermentation and fermentation by A.niger and double-separation.

皂素又名皂苷元，难溶于水，易溶于苯、氯仿等有机溶剂，是一种重要的甾体激素药物合成原料，主要用于脑体激素类药物的合成，如黄体酮、抗多灵、口服避孕药等药物合成原料，在医药生产中具有十分重要的应用价值，有&药用黄金&的美称［1］。

AR signalling can be activated in HR tumours through several mechanisms. First, activation of intracellular signal transduction pathways can sensitize the AR to castrate levels of androgens. Also, mutations in the AR can change AR ligand specificity, thereby allowing it to be activated by non-steroids or anti-androgens. Finally, overexpression of the wild-type AR sensitizes itself to low concentrations of androgens.

HRPC的AR信号通路活化机制包括：胞内信号传导途径可以增加 AR对于去势治疗后低水平雄激素的敏感性；AR的突变也可改变其对于配体的选择，使得非甾体类激素甚至抗雄激素药物也能够激活AR；此外，野生型AR的过表达也促进了自身对于低浓度雄激素的敏感性。

The abnormal Beckmann rearrangement of steroid-17-one oximes affords the corresponding alkylene-nitrile product as important intermediates for this purpose.

对九个甾体-17-酮肟的非正常Beckmann重排反应研究发现甾体分子上的取代基和立体化学对反应没有明显的影响（Scheme 1）。

Chinensis by the methods of column chromatography (normal and reversed phase silica gel, Sephadex LH-20), preparative TLC and HPLC. On the basis of spectroscopic methods including IR, ESI-MS, 1-D and 2-D NMR, forty eight of them were identified as seventeen flavonoids, seventeen tritepenoids, one cumarin, five steroids and some benzene derivative etc.

中药射干为射干植物的干燥根茎，从中共分离出53个化合物，通过红外、质谱及核磁共振等波谱方法鉴定了包括12个新化合物在内的48个，结构类型分别属于iridal型三萜及其新颖的二聚体、异黄酮、黄酮及黄酮醇、香豆素、甾体、芳香酸和脂肪酸及其甘油酯等。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。