电子等排的

Weishite is located in the beautiful coastal city - geese city, guangdong huizhou, is a set of development, production, sales for the integration of electronic soft lines enterprise specialized in producing products are widely used in household electric appliance, digital products, computer peripheral equipment, digital communication equipment, automobile electric appliances, wireless instrumentation and so on many domains.

威仕特电子座落于美丽的鹅城－广东省惠州市，是一家集开发、生产、销售为一体的电子软排线专业制造企业，产品广泛应用于家电数码、电脑周边设备、通讯设备，汽车电器，无线仪器仪表等诸多领域。

Based on the bioisosterism of malonate group with phosphate group, a series of barbiturate compounds and pyrazolidine-3, 5-dione compounds were designed and synthesized.

基于丙二酸是磷酸的生物电子等排体，我们设计了丙二酸的闭环结构的巴比妥酸及3，5-吡唑烷二酮类化合物。

Electronic page composition system: A complete system comprises the colour scanner,text input ,a CPU that provides masking,page assembly,tint applying functions and a laser image setter.

电子排版系统：一套完整的系统设备包括分色机、文字输入机、具有拼版及在版面上加蒙片和平网等功能的中央处理机和激光图文影排机。

Given the success of 9-aminocamptothecin and meanwhile to investigate the impact of substituents with electron-donating groups on the activity of these compounds, amino group was incorporated into the 7-position of benzimidazole, benzoxazole or benzothiazole.

将第Ⅲ类化合物中的喹诺酮环用其电子等排体色酮环代替，得到第Ⅲ类化物，以考察喹诺酮的氮原子被氧原子取代后对活性的影响，该类化合物包括9个化合物，其中含4个色酮开环产物。

PVC Card - Business card printing 】Imagesetter was developed a new device that is using the computer for an input text symbols proofing, editing, and then the exposure by laser-scanning technology Imaging in sencitivity that the use of scanning beam brightness focused by a high, as to the very fine beam, the scan to the identity of lycoramine up to 40 line/MM, this setter it to text glyph outlines and flick, the text of high quality typesetting, interpuntion, has become the main force of text interpuntion, after more than 20 years of growing and changing as the types of technology, from the use of laser light apparatus'manufacture laser, argon ion laser and led, and so on, from the scan of the different ways to look at so, Prism scan, mechanical drum scanning and internal cylindrical drum scans several ways-galvanometric machanistic, but galvanometric high quality requirements with less.

激平照排机是70年代研制出来的一栽陈摆设，它是诳骗电子计算机差不不输入笔墨标记举不静校差，编纂办理，再堵住激平扫描技艺曝平不败像在感平质料上，使扫描平束亮量矮，不纬聚焦后到极细的平束，其扫描辨别辛可达40线/MM，因此这栽照排机能较好不天表不隐笔墨字形边框和笔锋，照排的笔墨质量矮，排版速率迟，已不败为笔墨排版的主辛军，不纬过二十众年的不停不败长，技艺日益美满，栽类不败群，从搁置激平平氦氖激平，氩离子激平和发平二级惯等，从扫描方法差别来看有，棱镜扫描，板滞式滚筒扫描和边方滚筒扫描等几栽次要方法，也有拔取振镜扫描式的，但差振镜质量请求矮而用得较众。

PVC Card - Business card printing 】Imagesetter was developed a new device that is using the computer for an input text symbols proofing, editing, and then the exposure by laser-scanning technology Imaging in sencitivity that the use of scanning beam brightness focused by a high, as to the very fine beam, the scan to the identity of lycoramine up to 40 line/MM, this setter it to text glyph outlines and flick, the text of high quality typesetting, interpuntion, has become the main force of text interpuntion, after more than 20 years of growing and changing as the types of technology, from the use of laser light apparatus'manufacture laser, argon ion laser and led, and so on, from the scan of the different ways to look at so, Prism scan, mechanical drum scanning and internal cylindrical drum scans several ways-galvanometric machanistic, but galvanometric high quality requirements with less.

激平照排机是70年代研制出来的一栽陈摆设，它是诳骗电子计算机差不不输入笔墨标记举不静校差，编纂办理，再堵住激平扫描技艺曝平不败像在感平质料上，使扫描平束亮量矮，不纬聚焦后到极细的平束，其扫描辨别辛可达40线/MM，因此这栽照排性能较好不天表不隐笔墨字形边框和笔锋，照排的笔墨质量矮，排版速率迟，已不败为笔墨排版的主辛军，不纬过二十众年的不停不败长，技艺日益美满，栽类不败群，从搁置激平平氦氖激平，氩离子激平和发平二级惯等，从扫描方法差别来看有，棱镜扫描，板滞式滚筒扫描和边方滚筒扫描等几栽次要方法，也有拔取振镜扫描式的，但差振镜质量请求矮而用得较众。

Pymetrazine is chosed as the lead compound, and 21 compounds were firstly designed and synthesized. These compounds were characterized by introducing phenyl derivatives with different functional groups to replace pyridine ring with the isosteric principle and the method of homogeneous synthesis and reasonable biologically designing in order to find new compounds with potential biological activity. These compounds were confirmed by IR, H NMR and MS spectra.

本文选取吡蚜酮为先导化合物，运用电子等排理念，综合类同合成、生物合理设计的方法，引入含有不同官能团的苯基衍生物替代吡蚜酮的结构中心吡啶环，设计合成了21个未见文献报道的化合物，寻找具有潜在生物活性的新三嗪酮类化合物，通过核磁共振氢谱、红外光谱、质谱等手段进行了结构表征，并验证正确。

Methods: According to the mechanism of cough reflex, the c-fibres's role in the respiratory system, and the principle of isosterism. Here, a peripheral antitussive LD was regarded as a lead compound. Amino functional groups, as substituents at the 1-hydroxy group of the racemate of LD, were introduced into the structure of the molecule. These novel compounds were confirmed by 1H-NMR, MS spectrum. Their antitussive activities were studied on mice in sequential method. The EDT50, the stimulating time that caused cough by NH3 on half of mice, were measured. Then could caculated the ratio R between the EDT50 of the treated groups and control group.

根据咳嗽反射的机制及C-纤维在呼吸系统的作用，以外周镇咳药左羟丙哌嗪为先导化合物，依据电子等排原理，在其结构中引入氨基以取代羟丙哌嗪分子中1位的羟基，设计一系列未见报道的化合物（01-15）；并采用了一条适宜的路线进行合成，通过1H-NMR、MS确证结构；采用&序贯法&实验进行新化合物的镇咳活性研究，动物模型采用氨水引咳小鼠，获得引致半数小鼠咳嗽的氨水刺激时间（EDT50）及给药组EDT50与对照组的比值R。

Cis-C=C configuration on 2 position is easily isomerized to trans-form in environment according to literatures, but cycloproyl do it difficut relatively. So, replacement of 2,3- allyl unit by cyclopropyl group might give a practical method to get over the problem.

为解决脱落酸2位双键在环境中易光异构化为反式结构的问题，依据电子等排体原理，将2，3-位的烯丙型的结构改变为环丙型结构，将可能解决光异构化的问题。

According to the experience of the research of the indoles alkaloid, we designed a series of novel compounds which contained indoles heterocyclic as the flat aromatic group, benzyloxy substituent at indoles 6 site as the nonhydrophilic group tail, carboxylic derivatives and TZDs bioisosterism substituent at indoles 2 site or 3 site as the hydrophilic group head.

于是根据我们课题组多年来对吲哚生物碱研究的经验，我们设计了以吲哚作为中间平面芳环体系，6位连接苄氧基作为疏水尾部，2位或3位连接羧酸及其衍生物、噻唑烷二酮及其电子等排体的一系列化合物。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。