甲酰化

Methods Starting from 2-chloro-4-nitrophenol and 2- pyridine hydrochlorid, 3-chloro-4-(pyridin-2-ylmethoxy) aniline was obtained via etherization and reduction. The obtained aniline coupled with N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl) acetamide to give 4-[3-chloro-4-(2-pyridylmethoxy) phenylamino]-3-cyano-7-ethoxy-6-N-acetylaminoquinoline. And then it was deacetylated, followed by reacting with4- but-2-enoyl chloride to yield the target compound neratinib.

以2-氯－4-硝基苯酚和2-氯甲基吡啶为起始原料，经醚化、硝基还原得到3-氯－4-（吡啶－2-甲氧基）苯胺，3-氯－4-（吡啶－2-甲氧基）苯胺与3-氰基－6-乙酰氨基－7-乙氧基－4-氯喹啉反应得到3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉，3-氰基－6-乙酰氨基－4-［3-氯－4-（吡啶－2-甲氧基）苯氨基］－7-乙氧基喹啉去乙酰保护基后，与-4-二甲氨基－2-丁烯酰氯经酰化反应得到ner-atinib。

The conditions for HPLC to detect endogenous polyamines were optimized, that is, benzoylation for 30min at 37℃, detection wave length at 230nm, elution speed at 0.7ml·min〓 Using the above method, endogenous polyamines of calli in Citrus were analyzed.

优化了植物多胺的HPLC测定条件，确定在37℃苯甲酰化反应30min，检测波长230nm，流速0.7ml·min〓效果最佳。

As expected from the reaction mechanism, the carboxyl groups of aspartic and glutamic acid residues were not modified, while the amino group s that could react with the activated peptides were concomitantly protected by formylation.

如反应机理所预测的那样，天门冬氨酸和谷氨酸残基未被修饰，而能与活性肽反应的氨基则同时被甲酰化保护起来。

As expected from the reaction mechanism, the carboxyl groups of aspartic and glutamic acid residues were not modified, while the amino groups that could react with the activated peptides were concomitantly protected by formylation.

如反应机理所预测的那样，天门冬氨酸和谷氨酸残基未被修饰，而能与活性肽反应的氨基则同时被甲酰化保护起来。

Keywords 5-nitrosaicy|aldehyde polyphosphoric acid formylation Duff reaction

5-硝基水杨醛；多聚磷酸；甲酰化； Duff反应

METHOD Dofetilide was synthesized by steps of reaction (substitution ,reduction, methylsulfonylation and methylammoniation, etc) from p-nitrophenol and p-amino phenethyl alcohol.

以对硝基苯酚为起始原料，经取代、还原、甲磺酰化等反应制得 4甲磺酰苯胺(5 )；以对氨基苯乙醇为起始原料，经甲磺酰化、甲氨化等反应制得 4 甲磺酰苯胺(8)，再与5经取代反应制得多非利特。

Some aqueous catalysis systems have been applied in the industrial production of butyl aldehyde by propene hydroformylation.

其中水溶性催化剂体系已经用于丙烯氢甲酰化反应制备丁醛的工业化生产，然而，长链烯烃在含有催化剂的水相中溶解性较差，反应速率较慢。

This thesis includes two parts. The first part is study on hydroformylation of alkenes in ionic liquid-H2O system.

本论文分两部分：咪唑离子液体—水体系中的烯烃氢甲酰化反应研究和新型咪唑类手性季铵盐的合成。

The function of water on α-cellulose membrane was also revealed by comparatively studying the gas permeability of cellulose acetate membrane, benzoylated cellulose membrane and polysulfone membrane in "dry" and "wet" state.

通过比较研究醋酸纤维素膜、苯甲酰化纤维素膜和聚砜膜在干态和湿态下的气体渗透性能，揭示了水对α纤维素膜气体渗透性能的作用规律

The experiment results indicated that the hydroformylation of C〓 straight chain higher olefins could well conduct under TPSC system.

实验结果表明，温控相分离催化体系可很好地催化C〓直链高碳烯烃氢甲酰化反应。

We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称；三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起，称之为挽歌体诗人或者史诗诗人，他们被称为诗人，似乎只是因为遵守格律写作，而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。