甲苯胺

Synthesis of target compounds namely: to vanillic acid as the starting material with methanol under reflux conditions for 4 - hydroxy -3 - p-methyl, then ether, and nitration, reduction, cyclization reaction 6 - methoxy -7 - benzyloxy-quinazoline -4 - one, and then by the chloride in place of aniline, benzyloxy-off, such as etherification reaction of the target compounds; target compounds with the second and third occurrence of substitution reactions of amines by the TM1, that is, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(N, N-diethyl amino) oxy c] quinazoline; with ether occurred Ornidazole reaction of TM2, namely, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(2 - methyl -5 - nitroimidazole) C oxy] quinazoline.

本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

METHOD Dofetilide was synthesized by steps of reaction (substitution ,reduction, methylsulfonylation and methylammoniation, etc) from p-nitrophenol and p-amino phenethyl alcohol.

以对硝基苯酚为起始原料，经取代、还原、甲磺酰化等反应制得 4甲磺酰苯胺(5 )；以对氨基苯乙醇为起始原料，经甲磺酰化、甲氨化等反应制得 4 甲磺酰苯胺(8)，再与5经取代反应制得多非利特。

Objective To compare characteristics of treponema pallidum antibody screening method with the toluidine red unheated serum test, the enzyme-linked immunosorbent assay and the T.

目的比较无偿献血者梅毒抗体筛查方法甲苯胺红不加热血清试验、双抗原夹心法的酶联免疫吸附试验和梅毒螺旋体明胶凝集试验的特性。

The serum samples from the patients who were TPHA-positive were tested in parallel by enzymeimmunoassay and syphilis toluidine red untreated serum test.

用TPHA进行抗梅毒抗体筛查，检测阳性的标本再用酶免疫法、甲苯胺红不加热血清试验、免疫印迹法进行检测。

Methods 34933 serum samples were screened by ELISA method on Treponema pallidum antibody. The samples with probable positive result were retested by toluidine red unheated serum test and Treponema pallidum particle assay. Results There were 559 serum samples with probable positive result.

对34933例标本采用酶联免疫吸附试验进行梅毒螺旋体的初筛，初筛结果为可疑阳性的样本进行梅毒螺旋体明胶凝集试验和甲苯胺红不加热血清反应素试验的检测。

Methods Three hundred and fifty-five clinical serum samples from persons with syphilis or without syphilis were detected by the Toluidine red unheated serum test, the T.pallidum particle agglutination assay and the recombintant antigen-based ELISA,respectively.

的 探讨基因重组抗原ELISA法在梅毒螺旋体抗体检测中的临床意义方法用甲苯胺红不加热血清实验对355份梅毒患者和非梅毒患者的临床血清标本进行检测。

At the third passage, BMSCs showed the typical polar swirl morphology. BMSCs were negative for CD34 and CD45, but positive for CD29 and CD44. Following induction, alkaline phosphatase staining, Oil red staining and toluidine blue staining produced a strong reaction in cells.

第3代骨髓间充质干细胞形态单一均匀，呈典型的极性漩涡状生长，不表达造血前体细胞标志抗原CD34和白细胞标志抗原CD45，表达整合素家族成员CD29和黏附分子CD44，经诱导后碱性磷酸酶染色、油红O染色和甲苯胺蓝染色均呈阳性。

Methods Each of two serological tests including TRUST and TPPA was employed to detect the serum antibodies against treponema pallidum in 86 patients with primary syphilis and normal control 100 patients respectively.

方法依据2000年中国卫生部防疫司颁布的性病诊断标准，临床筛选一期梅毒患者86例和非梅毒患者100例，对患者血清进行甲苯胺红不加热血清试验初筛和梅毒螺旋体明胶颗粒凝集试验确认。

Methods Each of two serological tests including TRUST and TPPA was employed to detect the serum antibodies against treponema pallidum in 86 patients with primary syphilis and normal control 100 patients respectively. FQ-PCR, Immun-PCR and autoantibody test were employed to diagnosis variability in all imcompatibility.

依据2000年中国卫生部防疫司颁布的性病诊断标准，临床筛选一期梅毒患者86例和非梅毒患者100例，对患者血清进行甲苯胺红不加热血清试验初筛和梅毒螺旋体明胶颗粒凝集试验确认。

Using N,N′-dimethy-p-toluidineas the catalyst,bisphenol A-glycidyl methacrylate,the resin matrix in most dental composite restorative materials,was synthesized by the reaction of bisphenol A and glycidyl methacrylate,and characterized by FTIR,~1HNMR and M S.

以N，N-二甲基对甲苯胺为催化剂，双酚A和甲基丙烯酸缩水甘油酯为原料合成了一种常用的口腔修复材料树脂基质———双酚A双甲基丙烯酸缩水甘油酯，并用FTIR1、HNMR和质谱对其结构进行表征。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。