甲基萘

The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

N-Methyl-3,3-dimethyl spiroindoline-2,3'[3H] naphthaline [2,1-b] [1,4] oxazine was synthesized by 1,3,3-trimethyl-2-methylene indoline and 1-nitroso-2-naphthol, its UV and IR spectra and elemental analysis were carried out, and the photochromism and main influencing factors such as temperature, solvent and pH were studied.

以1，3，3-三甲基－2-亚甲基吲哚啉和1-亚硝基－2-萘酚为原料合成了N-甲基－3，3-二甲基螺吲哚啉-2，3'[3H]萘并[2，1-b][1，4]恶嗪，对其进行了紫外和红外光谱以及元素分析，并对其光致变色性质以及主要影响因素温度、溶剂和pH进行了研究。

They are 4-(2- hydroxy-3-butynlenoxy) benzoic acid (1, WA), 5-chloro-7, 8-dihydroxy-7-methyl- 6-oxo-3- [ -3, 4-dihydroxy-3, 5-dimethyl-l-heptylene] -1H-8, 8a-dihydrobenzo [2, 3-c] pyran (2, WB),-2-(2-methyl-2-dibutene diamido)-2-butenoic acid (3, B5262), 3, 4-dihydro-9, 10-dihydroxy-7-methoxy-3-methyl-1H-naphtho [2, 3- c] pyran-1-one (4, A73 semi-Vioxanthin), 8, 8'-bis (6, 9-dioxo-3,4-dihydro-10- hydroxy-7-methoxy-3-methyl-1H-naphtho [2, 3-c] pyran-1-one)(5, A122 Xanthomegnin), 2, 5-dioxo-3a-hydroxymethyl-3, 3a, 6, 6a-tetrahydro-furo [2, 3-b] furan (6, 1003-2), 7-acety1-5-chloro-6, 8-dioxo-7-methyl-3- [ -3, 5-dimethyl-1, 3- diheptylene] -4aH-benzo [2, 3-c] pyran (7, M2-2 sclerotiorin), respectively.

它们分别被命名为4-（2-羟基-3-丁炔氧基）苯甲酸（1，WA）、5-氯-7，8-二羟基-7-甲基-6-氧代-3-[-3，4-二羟基-3，5-二甲基-1-庚烯基]-1H-8，8a-二氢苯并[2，3-c]吡喃（2，WB）、-2-（2-甲基-2-丁烯二酰亚胺基）-2-丁烯酸（3，B5262）、3，4-氢-9，10-二羟基-7-甲氧基-3-甲基-1H-萘并［2，3-c］吡喃-1-酮（semi-Vioxanthin，4，A73）、8，8'-双（6，9-二氧代-3，4-二氢-10-羟基-7-甲氧基-3-甲基-1H-萘并［2，3-c］吡喃-1-酮）（Xanthomegnin，5，A122）、2，5-二氧代-3a-羟甲基-3，3a，6，6a-四氢-呋喃并［2，3-b］呋喃（6，1003-2），7-乙酰基-5-氯-6，8-二氧代-7-甲基-3-［-3，5-二甲基-1，3-庚二烯基］-4aH-苯并2，3-c］吡喃（Sclerotiorin，7，M2-2）。

Five Butenafine's analogues were designed and synthesized according to the structure-activity relationship and operating mechanism of benzylamine antimycotics.

根据苄胺类抗真菌化合物的构效关系、作用机理，设计合成了 5个布替萘芬类似物，N (2 氯 5 吡啶甲基) N 甲基 1 萘甲胺，N ，N 二(4 叔丁基苄基) 1 萘甲胺，N (4 叔丁基苄基) N (2 氯 5 吡啶甲基) 1 萘甲胺，N ，N 二苄基 4 叔丁基苯甲胺，N (2 氯 5 吡啶甲基) N 苄基 4 叔丁基苯甲胺。

To be different from the already chloromethylation catalyst, it has a certain amount of moisture wet, which will not produce huge amounts of doughtic cancerogenic chloromethyl methyl ether during and after the reaction.4,4\'-bisbiphenyl, 1,4-bisbenzene, 1,4-bis(chloro- methyl)-2,5-dimethylbenzene, 1,5-bis-2,4-dimethylbenzene, 4-(chlor- omethyl)-1,2-dimethylbenzene, 1,2-bis-4,5-dimethylbenzene, 5,8-bis-1,2,3,4-tetrahydronaphthalene, 3,3\',5-tris-4,4\'-bisbiphenyl and 3,3\', 5,5\'-tetrakis-4,4\'-bisbiphenyl were synth- esized by using this new catalyst. Results indicated that when the reaction temperature was 55～60℃, the reaction time was 12h, the catalyst which consists of the concentration of 80%H_2SO_4, HAc and Lewis acid, the amount of Lewis acid 0.15 mol(nLewis:nbiphenyl=1.5:1), yield of biphenyl chloromethylation product 4,4\'-bis(chrolomethylbiphenyl can reach a maximum 85%.

采用这种催化体系完成了4，4′-二氯甲基联苯、对二氯甲基苯、1，4-二氯甲基-2，5-二甲基苯、1，5-二氯甲基-2，4-二甲基苯、4-氯甲基-1，2-二甲基苯、1，2-二氯甲基-4，5-二甲基苯、5，8-二氯甲基-四氢萘、3，3'，5-三氯甲基-4，4'-二甲基苯和3，3'，5，5'-四氯甲基-4，4'-二甲基苯的合成，结果表明：在反应条件为：反应温度55～60℃，反应时间12h，选择80%H_2SO_4、冰醋酸和Lewis酸为催化剂，反应最佳反应Lewis酸用量是0.15mol(和原料比为1.5：1)，反应效果最好，联苯氯甲基化产物(4，4′-二氯甲基联苯)收率为85%；在反应条件为：反应温度70℃，反应时间8h，80%H_2SO_4、冰醋酸和Lewis酸为催化剂，反应最佳反应Lewis酸用量是0.1mol(和原料比为1：1)时，反应效果最好，苯的氯甲基化产物收(来源：ABd0C论文eded网www.abclunwen.com)率为75%；在反应条件为：在反应条件为：反应温度40℃，反应时间10h，60%H_2SO_4和Lewis酸为催化剂，反应最佳反应Lewis酸用量是0.1mol(和原料比为1：1)时，反应效果最好，对二甲苯氯甲基化产物(1，4-二氯甲基-2，5-二甲基苯)收率为78.5%；在反应条件为：反应温度35℃，反应时间10h，60%H_2SO_4、冰醋酸和Lewis酸为催化剂，反应最佳反应Lewis酸用量是0.1mol(和原料比为1：1)时，反应效果最好，间二甲苯氯甲基化产物(1，5-二氯甲基-2，4-二甲基苯)收率为81.5%。

In this Ph. D. dissertation, reverse microemulsion method was fully used infabricating and modifying polyacrylamide with functional and high-relative moleculeweight. The copolymerization of 2-acrylamide-2-methylpxopanesulfonic acid, fluorescent monomer 4-methoxy-N-(2-N\', N\'-dimethylamino ethyl)naphthalimide alkyl chloride quaternary ammonium salt, fluorescentmonomer 4-(N\'-methyl-1-piperazinylallyl)-N-butyl-naphthalimide chloride quaternaryammonium salt, Cationic monomer dimethylethylammonium bromide and hydrophobical monomer octadecylacrylate with acrylamide and properties of the copolymers werestudied. The interaction between five polymers and Al_2O_3(012) crystal surface have beensimulated by Materials Studio 3.0 program package, binding energies and non-bondinteraction energies and deformation energies have also been acquired.

本文以制备具有较高相对分子质量和功能型PAM为研究目的，将反相微乳液法运用到其制备及改性的有关环节，通过反相微乳液聚合工艺，将几种改性功能单体2-丙烯酰胺基-2-甲基-丙磺酸、荧光单体2-(4-甲氧基-1，8-萘二甲酰亚胺基)-乙基二甲基烯丙基氯化铵、荧光单体4-(N'-甲基-1-哌嗪基)-N-丁基-1，8-萘烯丙氯季铵盐、阳离子单体丙烯酰氧乙基-二甲基-乙基溴化铵和疏水单体丙烯酸十八酯与AM共聚，制备AMPS改性PAM、荧光示踪型PAM、阳离子单体DMB改性PAM和OA改性PAM等四类不同功能单体改性PAM，并研究其应用性能。

In a DMF solution of CuCl〓-ethanolamine-acetic acid (1: 2: 2), 27 formed a highly oxidized heterocyclic compound 2-hydroxymethyl-naphtho [1, 2-a] oxazole (30) by the carbon-nitrogen coupling and carbon-oxygen coupling with the ligand of ethanolamine, which brings a chance to develop a novel approach to this heterocyclic compound via one-pot reaction of phenols under mild condition.

在氯化铜—乙醇胺—乙酸（1：2：2）的DMF溶液中，27与配体乙醇胺发生碳氮偶合与碳氧偶合，生成深度氧化的杂环化合物：2-羟甲基-萘并[1，2-a]〓唑（30）。这可望为酚类一锅化直接转化为30及其类似物提供一种简便的新合成路线。

A general method for preparing multi-cyclic indolizine compounds(1a—1c, 2a—2b and 3) in moderate yields(45%—71%) by a 1,3-dipolar cycloaddition reaction of pyridinium N-ylides, isoquinolinium N-ylides or quinolinium N-ylides to 1,4,4a ,8a-tetrahydro-1,4-methanonaphthalene-5,8-dione, followed by an aromatization, in the presence of tetrakispyridine cobalt dichromate is described.

在 [ 4Co( HCr O4 ) 2 ]存在下，吡啶叶立德、喹啉叶立德或异喹啉叶立德分别和 1 ，4，4a，8a-四氢-1 ，4-桥亚甲基萘-5 ，8-二酮反应，一步法合成了中氮茚类多环化合物( 1 a～ 1 c，2 a～ 2 b，3 )。该方法原料易得，反应条件容易控制，为合成这类化合物提供了新方

A series of polymers containing 1,8-naphthalimide moieties in the side chains have been prepared via RAFT technique. Firstly, five styrene and two methyl acrylate based 1,8-naphthalimide monomers were synthesized and characterized. Then, carbazyl group terminated polystyrene was used as macromolecular RAFT agent.

我们合成了5种苯乙烯类和2种甲基丙烯酸酯类萘酰亚胺单体，以一种含末端带咔唑结构的聚苯乙烯为大分子RAFT试剂，考察了所得单体的RAFT聚合，发现苯乙烯类1，8-萘酰亚胺单体可以聚合，但是聚合度不高，甲基丙烯酸酯类1，8-萘酰亚胺单体RAFT聚合不可控。

Conductivity of Polyoxyethylene/Poly (2-vinyl pyridine)Blend and Compatibilizing Effect of Lithium Perchlorate;2. Graft terpolymerization of polyoxyethylene macromer with acrylates;3. Then multiblock copolymers was obtained by condensing polyoxyethylene and poly(2 vinylpyridine)with dichloromethane in the presence of potassium hydroxide.

甲基萘锂作为引发剂利用阴离子聚合得到 2 乙烯基吡啶的遥爪双羟基低聚物(P2VP)，然后以二氯甲烷作偶联剂与聚环氧乙烷反应制备P2VP和PEO多嵌段共聚物，考察了反应时间对偶联反应的影响，并对共聚物进行了IR和1H NMR表征，由1H NMR谱的积分曲线得到了共聚物中PEO链段质量分数。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。