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甲基苯丙胺

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Experimental solubilities of terephthalic acid dissolved in N,N-dimethyl propionamide, N,N-diethyl propionamide and N,N-diethyl acetamide were determined in the temperature range of

测定了303.2~363.2K温度范围内,对苯二甲酸在N,N-二甲基丙酰胺、N,N-二乙基丙酰胺和N,N-二乙基乙酰胺中的溶解度。

Ophenyl phenol,ophenyl phenol sodium salt tetrahydrate,7ADCA,2ethyl phenyl hydrazine hydrochloride,2,3dihydrofuran,7ethyl3(2hydroxy ethyl)indole,methyl ester of etodolac; 1,8diethyl1,3,4,9tetrahydropyrano[3.4b] indole1acetic acid methyl ester,5chloro2methoxy benzoic acid,4(2aminoethyl)benzene sulfonamide,5cyano phthalide,phthalhydrazide,9thioxanthenone,n[(1,4benzodioxane2yl)carboxyl]piperazine HCL,2chloro4amino6,7dimethoxyquinazoline,2chloro benzimidazole,1(4fluorobenzyl)2chlorobenzimidazole,2methylthio4pyrimidone,5amino4imidazole carboxamide HCL,6chloro2hexanone,11oxo6.11hydrodibenzothiepin,6,11dihydrodibenzooxepin11one,10,11dihydrodibenzocyclohepten5one;dibenzosuberone,dibenzo cyclohepten5one;dibenzosuberenone,3,5dihydroxy benzoic acid,3,5dihydroxy benzyl alcohol,2mercapto benzimidazole,3,4dihydroxy benzaldehyde,3,4dihydroxy benzonitrile,2amino5chloro benzonitrile,2(4chlorophenoxy)ethyl chloride,2(4chloro phenoxy)tert,butane,ditrimethylol propane;DTMP,2,2bis(4hydroxyphenyl)butane; bisphenol B,1,1'bis(4hydroxyphenyl)cyclohexane;bisphenol Z,tetrabromobisphenolS,3,5ditertbutyl salicylic acid,3,4,5trihydroxy benzoic acid stearyl ester,1,2,4trimethoxybenzene.

华业公司产品:邻苯基苯酚,邻苯基苯酚钠盐,7氨基3去乙酰氧基头孢烷酸,邻乙基苯肼盐酸盐,2,3二氢呋喃,7乙基色氨醇,依托度酸甲酯,5氯2甲氧基苯甲酸,4(2氨乙基)苯磺酰胺,5氰基苯酞,双酮酞嗪,9噻吨酮,N〔(1,4苯并二恶烷2基)羰基〕哌嗪盐酸盐,2氯4氨基6,7一二甲氧基喹唑啉,2氯苯并咪唑,1(4氟苄基)2氯苯并咪唑,2甲硫基4嘧啶酮,5氨基咪唑4 甲酰胺盐酸盐,6氯2已酮,11氧6.11二氢苯并〔b.c〕虑平,11氧代6,11二氢二苯并氧杂卓,10,11二氢二苯并环庚烯5酮,二苯并环庚烯5酮,3,5二羟基苯甲酸,3,5二羟基苯甲醇,2巯基苯并咪唑,3,4二羟基苯甲醛,3,4二羟基苯腈,2氨基5氯苯腈,2(4氯苯氧基)1氯乙烷,2(4氯苯氧基)叔丁烷,双丙烷,2,2二(4羟基苯基)丁烷;双酚B,1,1'双(4羟基苯基)环己烷;双酚Z,2[3,5二溴4(2,3二溴丙氧基)]苯砜,3,5二叔丁基水杨酸,3,4,5三羟基苯甲酸十八烷基脂,1,2,4三甲基氧基苯。

Water, Cyclomethicone, Glycerin, Sd Alcohol 40-B (Alcohol Denat.), Propylene Glycol, Melia Azadirachta Leaf Extract, Lecithin, Arctium Lappa Root Extract, Xylitol, Lactitol, Alpha-Glucan Oligosaccharide, Lactoferrin, Potassium Thiocyanate, Glucose Pentaacetate, Glucose Oxidase, Lactoperoxidase, Glycoproteins, Panax Ginseng Root Extract, Equisetum Arvense Extract, Hydrolyzed Milk Protein, Peg-8, Caprylyl Glycol, Sebacic Acid, Sodium Polyacrylate, Betula Alba Bark Extract, Cupressus Sempervirens Leaf Extract, Hamamelis Virginiana Extract, Avena Sativa Meal Extract, Humulus Lupulus Extract, Silk, Nylon-12, Polyacrylamide, Polymethyl Methacrylate, Butylene Glycol, Salicylic Acid, Lauryl Methacrylate/Glycol Dimethacrylate Copolymer, Tocopheryl Acetate, C13-14 Isoparaffin, Laureth-7, Triethanolamine, Xanthan Gum, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Phenoxyethanol, Chlorphenesin, Benzoic Acid, Methylparaben, Fragrance, Titanium Dioxide

水,环甲硅脂,甘油,Sd Alcohol 40-B,丙二醇,印度楝树叶萃取,卵燐脂,牛蒡根萃取,木糖醇,乳糖醇,α-葡低聚糖,乳铁蛋白,硫氰酸钾,葡萄糖五乙酸酯,葡萄糖氧化酶,乳过氧化物酶,糖蛋白,人参根萃取,问荆萃取,水解牛奶蛋白,聚乙二醇-8,辛乙二醇,癸二酸,聚丙烯酸酯钠,白桦萃取,丝柏叶萃取,金缕梅萃取,燕麦萃取,啤酒花萃取,丝,尼龙-12,聚丙烯醯胺,聚甲基丙烯酸甲酯,丁二醇,水杨酸,甲基丙烯酸十二酯,醋酸盐维他命E,C13-14 异烷烃,月桂醇聚醚-7,三乙醇胺,山羊胶,丙烯酸/C10-30烷基丙烯酸聚合物,苯氧乙醇,氯苯甘醚,苯甲酸,羟苯甲酯,香料,二氧化钛

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即:以香草酸为起始原料,与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯,然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮,然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物;目标化合物与二乙胺发生胺取代反应得到了TM1,即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉;通过与奥硝唑发生醚化反应得到TM2,即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Ingredients:water,glycerin,caprylic/capric triglyceride, cetyl alcohol ,propylene glycol,glyceryl stearate,panthenol,betaine dimethicone,simmondsia chinensis, rosa rugosa flower extract,allantoin,carbomer,parfum,triethanolamine,tocopheryl acetate,methyl paraben,propyl paraben,creatine,tetrasodium edta,phenoxyethanol,caprylyl glycol,sorbic.

成分:去离子水,甘油,辛酸/葵酸三甘油酯,鲸蜡醇,丙二醇,硬脂酸甘油酯,泛醇,甜菜碱,聚二甲基硅氧烷,霍霍巴油,玫瑰花提取液,尿囊素,卡波姆,香精,三乙醇胺,生育酚乙酸酯,对羟基苯甲酸甲酯,对羟基苯甲酸丙酯,肌酸,乙二胺四乙酸四钠,苯氧乙醇,辛二醇,山梨酸。

Polyelectrolyte hydrogels based on n -alkyl methacrylate esters,acrylic acid and acrylamide cross-linked with 4,4′-diazobenzene were prepared.

合成了不同疏水链长的甲基丙烯酸酯、甲基丙烯酰胺及丙烯酸与 4 ,4′-二偶氮苯交联共聚的聚电解质凝胶。

Hydrogels based on n -alkyl methacrylate esters,acrylic acid and acrylamide cross-linked with 4,4′-diazobenzene were preparared.

合成了带不同疏水侧基的甲基丙烯酸酯、甲基丙烯酰胺及丙烯酸与 4,4′二偶氮苯交联共聚的凝胶。

Hydrogels based on n -alkyl methacrylate esters,acrylic acid and acrylamide cross-linked with 4,4′-diazobenzene were preparared,and their deswelling kinetics was studied.

研究了甲基丙烯酸十二烷或丁酯、甲基丙烯酰胺及丙烯酸与4 ,4′-二偶氮苯交联共聚凝胶的消溶胀动力学。

To synthesize the octreotide, Phe-Leu-Glu-Glu-Leu and C_(15)H_(31)-CO-Lys-Thr -Thr-Lys-Ser peptides, the strategies are as followings: Fmoc- group as protective group for α-NH_2; TBTU, DIEA and HOBt as coupling reagent; and ethanedithiol -phenol - thioanisole - H_2O - TFA ( 2.5:5:5:5:82.5 , V/V ) as cleaving solution.

采用Fmoc固相合成法,以苯并三哗四甲基脲四氟硼酸盐、二异丙基乙胺和1-羟基苯骈三氮唑为缩合剂;苯酚—乙二硫醇—苯甲硫醚—水—三氟乙酸(5:5:2.5:5:82.5,V/V)为切割试剂,合成了奥曲肽、Phe-Leu-Glu-Glu-Leu及C_(15)H_(31)-CO-Lys-Thr-Thr-Lys-Ser三种小分子多肽,并对奥曲肽的合成规模进行了放大。

A process for preparingp-fluo-2-(2-methyl-3-propionyl)-4-oxy-N,3-diphenyl-phenylbutylamide includes such steps as Friedle-Craft acylating of newly prepared phenylacetyl chloride and fluorobenzene under catalysis of AlCl3 to obtain 4-fluoro-phenylbenzyl ketone, brominating at carbonyl alpha position under catalysis of less AlCl3 to obtain alpha-bromo-4-fluo-phenylbenzyl ketone, and condensing with isobutyryl acetanilide under action of sodium ethoxide.

本发明涉及一种制备对氟-2-(2-甲基-3-氧丙基)-4-氧-N,3-二苯基-苯丁酰胺(1)的方法,其包括以下步骤:新制的苯乙酰氯与氟苯在AlCl3催化下进行Friedle-Craft酰化反应,得到对4-氟-苯基苄基酮(4);化合物(4)在少量AlCl3催化下进行羰基α位溴化,得到α-溴-4-氟-苯基苄基酮(5);然后(3)异丁酰乙酰苯胺在乙醇钠作用下与化合物(5)进行缩合。

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