甲基吡啶

At present, the oil washing process methods domestic uses are washing oil by removing phenol in alkali, removing pyridine and quinoline in acid, getting naphthalene oil, methylnaphthalene oil and heavy oil after distillation.

目前，国内普通采用洗油加工方法是洗油经碱洗脱酚、酸洗脱吡啶和喹啉，蒸馏得萘油、甲基萘油和重油。

AIM: To establish a method to determine 2,6Dimethyl4(3nitropheny1)1,4 dihydropyridine3carboxylic acid dimethylester5carboxylic acid pentyl ester (MN9202) in biological medium by reversephase highperformance liquid chromatography.

目的：建立生物介质中1，4二氢2，6二甲基4(3硝基苯基)3，5吡啶二甲酸甲戊酯（MN9202）的高效液相色谱检测方法。

The details of this route as follows:With the piperidine as catalyst, p-hydroxylbenzaldehyde condensed with thiazolidine-...

同时，本文还对反应过程中产生的5-乙基-2-乙烯基毗啶、5-乙基-2-羟乙基吡啶、5-[(4-羟基苯基)甲基]-2，4-噻唑烷二酮、5-4-

We examined the association between intakes of the heterocyclic amines 2-amino-3,8-dimethylimidazo[4,5,-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine,2-amino-3,4,8-trimethylimidazo[4,5,-f] quinoxaline, and meat-deried mutagenicity and risk of distal colon adenoma using a cooking method questionnaire administered in 1996 in the Health Professionals Follow-up Study cohort.

我们卫生保健跟踪调查组采取烹调方法调查表的形式在1996年调查了摄入杂环胺2－氨基－3，8丙烷[4，5，-f] 喹噁啉，2－氨基－1甲基1－6－苯基亚氨基[4，5-b] 吡啶，2－氨基3，4，8－trimethylimidazo[4，5，-f] 喹噁啉和肉类衍生致突变物与患末端结肠腺瘤危险性的关系。

We examined the association between intakes of the heterocyclic amines 2-amino-3,8-dimethylimidazo[4,5,-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine,2-amino-3,4,8-trimethylimidazo[4,5,-f] quinoxaline, and meat-derived mutagenicity and risk of distal colon adenoma using a cooking method questionnaire administered in 1996 in the Health Professionals Follow-up Study cohort.

我们卫生保健跟踪调查组采取烹调方法调查表的形式在1996年调查了摄入杂环胺2－氨基－3，8丙烷[4，5，-f] 喹噁啉，2－氨基－1甲基1－6－苯基亚氨基[4，5-b] 吡啶，2－氨基3，4，8－trimethylimidazo[4，5，-f] 喹噁啉和肉类衍生致突变物与患末端结肠腺瘤危险性的关系。

Objective To investigate the neuroprotective effects of a sapogenin from Rhizoma Anemarrhenae on nigrostriatal dopaminergic neurons in chronic 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-lesioned mouse model.

目的 研究知母活性成分ZMR对慢性1-甲基－4-苯基－1， 2， 3， 6-四氢吡啶损伤小鼠模型黑质纹状体通路多巴胺神经元的影响。

Via comprehensive computations, the possibilities of vinylidene and allene intermediates were excluded, and the reaction mechanism was found to contain the following three steps:(1) gold-catalyzed cyclization to give the cyclic intermediate,(2) the cyclic intermediate undergoing a 1,3-H migration to give a more stable intermediate, with the assistance of water-cluster,(3) finially, the 1,2-H or 1,2-silyl migration occuring for generation of the observed product.

通过对各种可能的反应路径的进行计算和比较，排除了亚甲基卡宾和连二烯中间体的可能性，并确定该异构化反应机理包含以下三个步骤：（1）炔丙基吡啶反应在金催化条件下发生分子内的成环得到环状中间体；（2）环状中间体在水分子簇的协助下优先发生1，3-氢迁移反应，异构化得到更为稳定的中间体；（3）最后再进行1，2-氢迁移或是1，2-硅烷基团迁移即得到实验中所观察到的环异构化产物。

It manufactures heterocyclic, such as pyrazine, thiazole, furan, pyridine and sulf-compounds with their ramifications; and pharmaceutical intermediates such as veratraldehyde, isovanillin, sufurol, diacetyl, acetoin, and 2, 5-dimethyl pyrazine.

食用产品有吡嗪、噻唑、呋喃、吡啶等杂环系列及含硫系列的合成香料化合物。医药中间体产品有：藜芦醛、异香兰素、硫噻唑、丁二酮、乙偶姻、2，5-二甲基吡嗪等。

Based on the synthesis method and the function of decreasing blood glucose levels of rosiglitazone, and the report on benzoquinones which resulted in a significant decrease in blood glucose levels, a novel non-thiazolidinedione class of PPARy agonist 2, 5-Dihydroxy-3-{4-[2-(methyl- pyridin-2- yl-amino)- ethoxy] -phenyl}-6-phenyl-[l, 4] benzoquinone (4) was designed and synthesized.

在合成罗格列酮的基础上，根据某些醌类结构化合物的类似胰岛素作用，设计并合成了一种非噻唑烷二酮类PPARγ激动剂2，5-二羟基3-{4-[2-(甲基-2-吡啶氨基)-乙氧基]-苯基}-6-苯基-1，4苯醌(4)。

In this thesis,the AM1,MNDO,MINDO/3(mainly AM1)and INDO/S-CI semiempirical MO methods were used toinvestigate the excited-state intramolecular protontransfer reactions of salicylic acid derivatives—salicylic acid,methyl salicylate,salicylaldehyde,o-hydroxyaceto-phenone,salicylamide and 3-hydroxy-picolinamide (6 conformers and 2-3 anion species);2-(2'-hydroxy-5' methylphenyl) benzotriazole(4 conformers),2-(2' hydroxyphenyl) benzimidazole (3 conformers and 3anion species),Bis-2,5-(2-benzoxazolyl)hydroquinone(3 conformers),2-(2'-hydroxyphenyl)benzothiazole(2conformers) and 7-azaindole dimer (2 conformers).Theinvestigations were described as follows.Geometry optimization,relative stability andhydrogen bonding energy First,for sylicylic acid derivative molecules,the AM1,MNDO and MINDO/3 methods were used toinvestigate ground-state geometry optimization,energies,relative stabilities and hydrogen-bondingenergies on the five kinds of the molecules(designing 6 conformers and 2-3 anion species).Comparing with experimental data,the optimizedgeometry,the order of stability,the hydrogen-bonding energies and the distances between O-O in O-H..O hydrogen bonds by AM1 method were in agreementwith the experimental data,however,the C-C bondlengths optimized by MNDO and MINDO/3 were longer,C-O and O-H bond lengths were shorter;for C-N bondlengths,the results opitimized by MNDO method werethe same as those by AM1 method,nevertheless the C-Nbond lengths given by MINDO/3 method were muchshorter.For some sylicylic acid derivatives(e.g.methyl salicylate,salicylamide),the order ofstabilities on the conformers given by MNDO andMINDO/3 methods were not in agreement with theexisting conformers deduced by experimental methods,and the hydrogen bonding energies calculated by MNDO.and MINDO/3 methods were smaller.Second,the studyon the other systems found that the optimizedgeometry of the proton-transfered product with INDOmethod could not be obtained,only could theoptimized geometry of reactant be obtained,and thecalculated hydrogen bonding energies were greater.Many results of calculation indicated that the studyon the excited-state intramolecular proton transferreaction system using AM1 method was suitable andreliable.

本论文用AM1、MNDO、MINDO/3（主要是AM1）和INDO/S-CI半经验分子轨道方法对水杨酸衍生物系列——水杨酸、水杨酸甲酯、水杨醛、O-羟基乙酰苯酮、水杨酰胺和3-羟基吡啶酰胺（6种异构体和2-3种阴离子）；2-（2'-羟基-5'-甲基苯基）苯并三〓唑（4种异构体）；2-（2'-羟基苯基）苯并咪唑（3种异构体和3种阴离子）；2，5-二间氮杂氧茚氢醌（3种异构体）；2-（2'-羟基苯基）间〓杂硫茚（2种异构体）和7-〓吲哚二体（2种异构体）的激发态分子内质子转移反应在以下几个方面进行了较系统的理论研究：几何构型优化和相对稳定性及氢键能首先以水杨酸衍生物系列分子为例，用AM1、MNDO和MINDO/3方法考察了5种分子（每种分子设计6种异构体和2-3种阴离子）的基态几何构型优化，能量、相对稳定性和氢键能计算，通过和实验数据进行比较，AM1方法给出的优化几何构型、稳定性次序、氢键能和O—H。。。O氢键的0—0距离与实验数据吻合最好，MNDO和MINDO/3方法优化的C-C键长偏长，C-O键和O-H键长偏短；对于C-N键长，MNDO和AM1优化结果差别不大，而MINDO/3给出了过短的C-N键长，MNDO和MINDO/3方法给出的有些水杨酸衍生物分子（如水杨酸甲酯和水杨酰胺）异构体的稳定性次序和实验上推测的可存在异构体结果不一致，MNDO和MINDO/3方法给出的氢键能偏低，对其他体系的研究发现INDO方法常常不能得到质子转移产物的优化几何构型，只能得到反应物的优化构型，并且估算的氢键能偏高，大量的计算结果表明AM1方法对本论文研究的激发态分子内质子转移反应体系是适宜和可靠的。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。