甲基化的

METHODS 3-methoxy-7α-methylestra-1,3,5(10)-trien-17β-ol was reducted with lithium and ammonia,then the intermediate was hydrolyzed in oxalic acid and reacted with malonic acid to get 3,3-dimethoxo-7α-methylestra-5(10)-en-17-ol(compound 4),which was oxidated by pyridium bichromate ,reacted with acetylene,and hydrolyzed in oxalic acid again to get the product tibolone.

方法以3-甲氧基-7α-甲基雌甾-1，3，5(10)-三烯-17β-羟基为起始原料经锂胺还原、草酸水解、缩酮化得3，3-二甲氧基-7α-甲基雌甾-5(10)-烯-17β-羟基(化合物4)，然后用温和的氧化剂重铬酸吡啶盐氧化、炔化、再水解得目的产物。

Linear solvation energy relation was firstly introduced in the paper, and the method and step of gaining the special parameters of solvent and solute were introduced in detail, and these special parameters were used to selection and optimization of extractive agent in extractive distillation. The model of predicting activity coefficient at infinite dilution was established by linear solvation energy relation. By the above theory, several candidate solvents were selected to separate C5 fraction, and by experiment of vapor-liquid phase equilibrium at atmosphere pressure, the mixture of N-methyl-pyrrolidone including 4% water was used extractive agent of separating C5 fraction. Then binary vapor-liquid phase equilibrium of the some compound in C5 fraction and N-methyl-pyrolidone were determined at atmosphere pressure and correlated by NRTL equation. Isoprene being objective compound, experiments were operated in the laboratory-scale column; the processes were simulated by RadFrac model in ASPEN PLUS. And by the combination of experiment and simulation, the new process of separation of C5 was established.

本文首先对线性溶剂化能关系进行了分析介绍，也介绍了采用溶剂化能关系得到溶质溶剂特性参数的方法步骤，并将这些参数用于萃取精馏萃取剂的选择与优化；也通过线性溶剂化能关系式建立无限稀释活度系数预测模型，取得了一定的预测精度；将通过上述方法初选的溶剂进行了常压汽液平衡的测定研究，通过实验研究选定含水4%的N-甲基吡咯烷酮溶液做为C5分离的萃取剂，测定了大量N-甲基吡咯烷酮与C5组分的二元平衡数据，并进行关联计算；以异戊二烯为目标产物在实验室规模的精馏塔内进行了C5分离的实验研究，取得大量塔内数据；通过选用合适的热力学模型，采用ASPEN中RadFrac模块对分离过程进行模拟研究，通过实验与模拟相结合，建立了C5分离的新工艺，为将来的工业化打下了坚实的基础。

In this study, we found that β-catenin, c-JUN, c-myc and GSK3β might be involved in squamous metaplasia of airway epithelium induced by methylcholanthrene, vitamin A deficiency or cigarette smoking by investigating the rat model of squamous metaplasia.

本项目通过维生素A缺乏、吸烟及气管内注入甲基胆蒽复制体外气道上皮鳞化动物模型，发现β-连环素、c-JUN、c-myc 及GSK3β可能介导了甲基胆蒽、VitA 缺乏与吸烟所致的大鼠支气管上皮鳞状化生。

The Tg for a mass ratio mixture of Galpi and sucrose of 0.3/1 was greater than 0 and was similar to that of the same ratio mixture of raffinose to sucrose, indicating that Galpi as well as oligosaccharides plays an important role in glass formation.

甲基肌醇半乳吡喃糖和蔗糖以0.3对1重量浓度混合比例，其玻璃质化转移温度在0℃以上，且近似於相同比例之寡糖类和蔗糖混合，显示甲基肌醇半乳吡喃糖和寡糖类在玻璃质化形成上扮演重要的角色。

In the process of laboratory study, oxycodone was prepared by oxidating thebaine at 6,14-position under oxydol, hydrodeoxidizing 7,8-position double bond and 14-position ether under palladium catalyst. Furthermore, N-methyl of oxycodone was isolated byα-chloro-ethyl chloroformate under anhydrous condition and protection of 14-position hydroxyl to obtain noroxycodone, which was further converted into methylnaltrexone by N-alkylation in presence of cyclopropyl bromomethane, then by isolating 3-position methyl of methylnaltrexone under boron tribromide, becoming hydrochloride to prepare target compound, natrexone hydrochloride.

实验室工艺方面，本文首先用双氧水氧化蒂巴因的6-位和14-位、在钯炭催化下加氢还原7-8位双键和14-位醚合成羟考酮，然后提出并优化了在无水和14-位保护的情况下，用氯甲酸-α-氯乙酯脱去羟考酮的N-位甲基合成去甲羟考酮，再用环丙甲基溴将去甲羟考酮的N-位烷基化合成甲基纳曲酮，最后采用三溴化硼脱去甲基纳曲酮的3-位甲基和成盐酸盐合成盐酸纳曲酮。

In this Ph. D. dissertation, reverse microemulsion method was fully used infabricating and modifying polyacrylamide with functional and high-relative moleculeweight. The copolymerization of 2-acrylamide-2-methylpxopanesulfonic acid, fluorescent monomer 4-methoxy-N-(2-N\', N\'-dimethylamino ethyl)naphthalimide alkyl chloride quaternary ammonium salt, fluorescentmonomer 4-(N\'-methyl-1-piperazinylallyl)-N-butyl-naphthalimide chloride quaternaryammonium salt, Cationic monomer dimethylethylammonium bromide and hydrophobical monomer octadecylacrylate with acrylamide and properties of the copolymers werestudied. The interaction between five polymers and Al_2O_3(012) crystal surface have beensimulated by Materials Studio 3.0 program package, binding energies and non-bondinteraction energies and deformation energies have also been acquired.

本文以制备具有较高相对分子质量和功能型PAM为研究目的，将反相微乳液法运用到其制备及改性的有关环节，通过反相微乳液聚合工艺，将几种改性功能单体2-丙烯酰胺基-2-甲基-丙磺酸、荧光单体2-(4-甲氧基-1，8-萘二甲酰亚胺基)-乙基二甲基烯丙基氯化铵、荧光单体4-(N'-甲基-1-哌嗪基)-N-丁基-1，8-萘烯丙氯季铵盐、阳离子单体丙烯酰氧乙基-二甲基-乙基溴化铵和疏水单体丙烯酸十八酯与AM共聚，制备AMPS改性PAM、荧光示踪型PAM、阳离子单体DMB改性PAM和OA改性PAM等四类不同功能单体改性PAM，并研究其应用性能。

Using pentaerythritol as initiator, boron trifluoride diethyl etherate as catalyst.dichloroethane as dispersion agent, the chloride polyether polyol is synthesized based on the mechanism of cationic ring-opening polymerization of epiclilnrohyclrin.The azide polyether polyol is synthesized, in DMF through A and sodium azide, and the non-reported azide energetic curing agent is synthesized through the adduction of B and IIDI.

以季戊四醇为起始剂，三氟化硼乙醚为催化剂，1，2—二氯乙烷为分散剂，环氧氯丙烷经阳离子开环聚合反应制成氯化聚醚多元醇，A在N，N—二甲基甲酰胺中与叠氮化钠反应制得叠氮聚醚多元醇，B与六亚甲基二异氰酸酯加成反应制得未见文献报道的叠氮固化剂。

Four hemicyanine derivatives,-N-(4-sulfobutyl)-4-[2-(4-N,N-dimethylamino-phenyl) etheny1] pyridinium (P1),-N-(4-sulfobutyl)-4-[2-(4-N,N-dimethylaminophenyl)-1,3-buteny1] pyridinium (P2),-N-(4-sulfobutyl)-4-2-(4-N,N-dimethylaminophenyl) ethenyll quinolinium (Q1) and-N-(4-sulfobutyl)-4-

合成了具有不同共轭链长度的吡啶盐类及喹啉盐类半菁染料-N-（4-磺酸丁基）-4-[2-4-N，N-二甲基氨基苯基）乙烯基]吡啶鎓盐(P1、-N-（4-磺酸丁基）-4-[2-4-N，N-二甲基氨基苯基）丁二烯基]吡啶鎓盐(P2、-N-（4-磺酸丁基）-4-[2-(4-N，N-二甲基氨基苯基)乙烯基]哇琳鎓盐(Q1)以及-N-（4-磺酸丁基）-4-[2-4-N，N-二甲基氨基苯基丁二烯基]喹啉鎓盐(Q2)。研究了它们的光物理性质，并将它们用作TiO2纳米晶电极的光敏化剂引入光电化学电池。

Chiral 3 methy 1,4 butanediol and its derivatives are the important intermediate of synthesis of chiral smectic liquid crystal polyesters and chiral natrual products with biological activity. In the paper, a new efficient route of 3 methyl 1,4 butanediol and its two derivatives, 2 methyl 4 tetrapyranyloxy 1 butanol and 2 methyl 4 tetrapyranylbutanal, was described, and the target products were synthesized by employing asymmetric hydroboration oxidation improved.

手性2－甲基－1，4－丁二醇及其衍生物是合成各种手性近晶型液晶材料以及手性天然生物活性物质的重要中间体，以3－甲基－3－丁烯－1－醇为原料利用改进的不对称硼氢化－氧化反应，成功地合成了－2－甲基－1，4－丁二醇以及其2种手性衍生物：－2－甲基－4－四氢吡喃氧基－1－醇和－2－甲基－4－四氢吡喃氧基丁醛。

The bromo-polyethylenegylcol-monomethacrylate was synthesized by two steps. Firstly, methylacrylic acid was esterified with polyethylene glycol (PEG, M=200, 400) to give polyethyleneglycol-monomethacrylate Secondly, treatment of PEG-MA with phosphorus tribromide gave the aim product.

以聚乙二醉（M分别为200，400）和甲基丙烯酸进行单酯化反应，所得单酯再与三溴化磷进行溴化反应合成了一种新的两端具有功能团的不饱和溴化物，即溴代甲基丙烯酸单聚乙二醇酯。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。