甲基化的

In this thesis, a convenient and efficient synthesis of highly functionalizeddihydropyrido[2,3-d]pyrimidines via a double [5 + 1] annulation strategy startingfrom easily available α-alkenoyl-α-carbamoyl ketene--acetals 1 and cheapreagents (NH4OAc, DMF, and POCl3) has been developed.

本论文探索了一种简便有效的合成高度官能化的二氢吡啶并[2，3-d]嘧啶的方法，此方法由易得的α-乙酰基-α-氨基乙酰基二硫缩烯酮1和便宜的试剂(醋酸铵，二甲基甲酰胺和三氯氧磷)通过两步[5 + 1]加成而实现。

Study on detecting hypermethylation of the related genes in pancreastic juice to diagnose pancreatic diseases INTRODUCTION Pancreatic cancer is still one of the most common malignant cancers to human, and it is the fourth and sixth cause of death in American and Europe, and also the fifth cause of death in Japan, in our country is the tenth cause of death.

胰液中相关基因高甲基化检测在胰腺疾病诊断中的应用研究前言胰腺癌是二十一世纪人类面临的高度恶性肿瘤之一，在北美洲和欧洲分别占癌症死亡原因的第四位和第六位，在日本占第五位，在我国为前10位。90％的胰腺癌患者在诊断后一年内死亡，诊断后平均生存时间为三个月，适合手术者低于15％，手术平均切除病例的术后5年生存率低于4％。

Subsequently,enol methylation of P in basic condition completed the synthesis of malyngamide O.Applied this route to the synthesis of malyngamides Q and R,the chiral unsaturated acid was connected with the vinyl chloride part by amidation,then the resulting product was converted into the corresponding aldehyde,followed by aldol condensation of the aldehyde with the chlorotitanium enolate of pyrrolidone to complete the skeleton of malyngamides Q and R,then the synthesis of them was completed via enol methylation in acid condition.

该合成路线拓展应用到malyngamides Q和R的合成时，首先用酰胺键将手性不饱和脂肪酸和烯氯片段连接，再转化成相应的醛，与乙酰基吡咯酮进行TiCl_4催化的aldol反应即得到malyngamides Q和R的骨架结构，再经过酸催化的烯醇甲基化反应完成了Q和R的全合成。

Those little tykes, just 24 nucleotides long, are somehow responsible for methylation of DNA sequences that match the sequence of the siRNAs, but not without a lot of help from their friends.

这些siRNAs，仅仅具有24个核苷酸的长度，负责甲基化与它自身序列配对的DNA序列，这种过程是在其他&朋友&的帮助下进行的。

Those little tykes, just 24 nucleotides long, are somehow responsible for methylation of DNA sequences that match the sequence of the siRNA s, but not without a lot of help from their friends.

这些 siRNA s，仅仅具有24个核苷酸的长度，负责甲基化与它自身序列配对的DNA序列，这种过程是在其他&朋友&的帮助下进行的。

Further analysis suggested that about half of total sites experienced adjustments of DNA methylation patterns in different ploidy watermelons.

进一步分析证明，在检测到的遗传位点中，约有一半的位点DNA甲基化模式在不同倍性的西瓜中发生了调整。

The homogeneous catalysts for selective O-methylation of phenols with DMC are generally organic bases, such as tertiary amines or phosphines, tetrabutylammonium halide and Schiff bases.

酚与DMC甲基化反应的均相催化剂一般选择叔胺、叔膦、季铵盐及Schiff碱等有机碱，多相催化剂为碱金属碳酸盐、沸石、氧化铝及附载有金属盐的氧化铝和煅烧的Mg-Al水滑石。

It is found that we can re-express some silenced tumor suppressor genes containing CpG Island via demethylating pathway and reverse their tumor suppressing function in vitro.

前列腺癌治疗中应用相应的去甲基化制剂以改变前列腺癌细胞的生物学行为的研究，目前尚未见报道。

As the 12th of July-- the climax of the celebrations-- approached, officials of the Orange Order burned methylated spirits on the stone steps of the Orange Hall to cleanse any marks Catholics may have left there in the previous 12 months.

随着7月12日——庆祝活动的高潮——逐渐临近，奥伦治党的官员们在奥伦治会堂的石阶上点燃甲基化酒精，以清洗12个月来天主教徒可能留下的任何痕迹。

DNA CpG island methylation can result in the transcriptional inactivation of tumor suppressors genes, which facilitate tumor progression.

CpG岛甲基化可导致基因启动子的功能异常，引发基因转录的静息，最终导致功能蛋白的下调和缺失，从而促进肿瘤的发生和发展。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。