甲基化的

Results The synthesis condition was improved. The method of methane sulfonic acid/DL-methionine was found an ideal substitute of BBr3 for less cost. While using hydrobromic acid, the O-demethylation and hydrolyzation could be combined in one stage.

结果 优化了纳洛酮的合成工艺，甲磺酸／DL-甲硫氨酸法试剂价格低廉，可降低生产成本；而氢溴酸法不但试剂价格更低，还可将去氧甲基化和水解合并为一步反应，使新工艺的总收率提高到59.90%，产品质量符合中国药典。

Objective To observe the methylation status of p16 tumor suppressor gene in human soft tissue leiomyosarcoma and its relationship with p16 protein expression.

目的 探讨软组织平滑肌肉瘤中p16基因INK4A的甲基化状态及其与p16表达的关系。

Methylation of p16 gene probably plays a role in the pathogenesis of acute lymphoblastic leukemia and may have a prognostic value.

p16基因甲基化在ALL发生机制中有一定的作用，可作为评估ALL预后的一个指标。

To address this question in an unbiased and genome-wide manner, we developed a new method, methylation-specific digital karyotyping, and applied it to epithelial and myoepithelial cells, stromal fibroblasts from normal breast tissue, and in situ and invasive breast carcinomas.

为了能无偏向地并在基因组范围解答这个问题，我们开发了一种新的方法——甲基化特异性数字染色体组型，并将这一方法应用于上皮细胞和肌肉上皮细胞、正常乳腺组织来源的基质成纤维原细胞、原位及侵入性乳腺癌细胞。

The absorption maxima and emission maxima didnt change obviously between the five-membered compounds when N-methyl as the bridge atom. The value of extinction coefficient was increased obviusly compared naphthalimide with naphthalic anhydride.

甲基化氮为桥原子的五元化合物之间最大吸收和发射波长相差不大，萘酰亚胺的消光系数比萘酐增加明显，loge最大相差可达0.45，荧光强度也略有增加，相差0.1左右。

Herein, a series of compounds, BP-C〓-NBD (n=2, 3, 4, 5, 6, 8, 10), was synthesized. Nanosecond flash photolysis, phosphorescence emission and lifetime, as well as photoisomerization reaction of norbornadiene were used to understand the intramolecular triplet energy transfer in detail.

我们设计、合成了以多亚甲基连接的二苯酮与降冰片二烯（BP-C〓-NBD，n=2，3，4，5，6，8，10）系列化合物，利用纳秒时间分辨技术、低温磷光发射、磷光寿命以及光敏异构化的方法，对其分子内三重态能量传递过程进行了详细地研究。

Based on the observation that mammalian cells appear to be dependent on methylation for activation, SAHH has recently been selected as an attractive specific target for design of agents for immunosuppression, antiviral, treatment of atherosclerosis and Alzheimer's disease.

鉴于SAHH在调节生物体转甲基化反应中的核心地位，它已被选择作为多种新药研发的重要靶点，包括免疫抑制剂、抗病毒药、防治动脉粥样硬化和阿尔茨海默病药物。

The pharmacokinetic parameters of scutellarin were significantly different in normal and model rats. The metabolic pathways of scutellarin was proposed to be dehydroxylation and methylation.

正常和模型大鼠体内灯盏乙素的药动学参数有显著性差异；灯盏乙素在大鼠血浆样品中的代谢主要是脱羟基和甲基化途径。

DNA methylation on CpGs constitutes an epigenetic mark generally correlated with transcriptionally silent condensed chromatin.

DNA序列中CpGs结构的甲基化对表观遗传的调节具有显著作用，它可以使染色体转录沉默。

SAMe actually donates a part of itself to form these new compounds through a process called methylation or transmethylation.

其实捐出了自己的一部分一样，形成新化合物或转移的过程称为甲基化。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。