甲基化的

We found that NaBu stimulated ALAS2 gene expression not only in erythroid K562 cells, but also in non-erythroid 293T cells with a concurrent increase in acetylation level of histone H3 and dimethylation level of K4 at the same histone at ALAS2 gene promoter.

同时ALAS2基因启动子的组蛋白H3乙酰化水平以及组蛋白H3的第4位赖氨酸的双甲基化水平升高。

Biological studies indicated that these conjugation could form quinone methide intermediate after illumination.

该类化合物能在光诱导下产生与核酸形成烷基化或交联化的醌的甲基化物中间体。

The bacterial, mammalian and plant cytochrome P450s involved in metabolism of herbicides are reviewed in this paper. The action modes of cytochrome P450s on herbicides including dealkylation, ring-methyl hydroxylation and aromatic ring hydroxylation etc are summarized.

本文综述了代谢除草剂的细菌、哺乳动物和植物细胞色素P450酶系，概述了细胞色素P450酶系参与除草剂代谢的作用方式：脱烷基化作用、环甲基化羟基化作用和芳环的羟基化作用等。

We have investigated whether the combination of decitabine and a clinically relevant inhibitor of histone deacetylase activity (belinostat, PXD101) can further increase the re-expression of genes epigenetically silenced by DNA methylation and enhance chemo-sensitisation in vivo at well-tolerated doses.

我们研究了地西他滨联合组蛋白去乙酰化酶抑制剂（belinostat，PXD101）是否可以进一步增加DNA甲基化后生沉默基因的重新表达，在耐受性良好的剂量下增加化疗敏感性。

Based on the methylation analysis of the glycan and 〓C NMR spectroscopy of the glycoconjugate, one of the probably structure of repeat unit of the glycoconjugate was estimated as follow:- [→4 βGlcp (1→4)βGlcp (1→4)βGlcp (1→4)βGlcp (1→4)βGlcp (1→4)βGlcp (1→4)-βGlcp (1→4)βGlcp (1→] 〓→4)βGlcp (1→3)βManp (1→3)βRhap (1→3)βRhap (1→3)-↓↓βGalp βArap -βRhap (1→3)βRhap 1→ GFPE, which was the extracellular polysaccharide, was sulfated and the production was called GFPEs, which sulfated radicals content was 20.02%.

以甲基化反应及核磁共振的方法分析糖链结构，假设糖链GFPI-g具有重复结构单元，其可能的一种重复单元结构为：〓对灰数花胞外多糖GFPE的硫酸化修饰产物命名为GFPE-s，硫酸根含量为20.02％。

Dot1 binding to chromatin occurs normally in the absence of H2B-K123 ubiquitylation, suggesting that ubiquitylation does not regulate enzyme recruitment but does regulate the processive activity of the histone methyltransferase.

Dot1结合到染色质通常出现在H2B－K123没有泛素化的状态，暗示泛素化并不调节酶的募集，但调节组蛋白甲基转移酶后续作用的活性。

At last,a convergent and general protocol to marine natural product,as demonstrated by the enantioselective total synthesis of malyngamides O,P,Q,R, 5"-epi-Q and 5"-epi-R bearing terminal vinylic chloride structure,was developed in detail.E,(7S)-7-methoxytetradec-4-enoic acid was prepared using the above described Johnson-Clainsen rearrangement,the terminal vinyl chloride was constructed using Wittig reaction as key step,the pyrrolidone derivative was constructed using L-serine as natural chiral pool.Starting from the synthesis of malyngamides O and P to explore the general route,an aldol reaction of methyl acetate with the vinyl chloride part in the presence of LDA gave the skeleton of amine portion,followed by amidation with the fatty acid finished the synthesis of malyngamide P.

先以malyngamides O和P为试点探索通用合成路线，将乙酸甲酯和烯氯部分在LDA存在下进行aldol反应得到氨部分的骨架，再将手性不饱和脂肪酸和氨部分进行酰胺化反应完成了malyngamide P的合成，将P在碱性条件下进行烯醇甲基化反应完成了malyngamide O的全合成。

Because of its nonpoisonous, DMC can substitute phosgene , dimethyl sulfate or methylating used as methyl pharmaceutical to improve the security of production and reduce the environmental pollution; As the solvent, DMC can substitute fluorine lyons , methyl chloroform , trichloroethylene , benzene , dimethylbenzene, etc.. And it can be used as the paint dope, clean solvent. As gasoline additive, DMC can raise hard octane value and oxygen content and improve its antiknock possibility.

由于DMC无毒，可替代剧毒的光气、硫酸二甲酯等作为甲基化剂或羰基化剂使用，提高生产操作的安全性，降低环境污染；作为溶剂，DMC可替代氟里昂、三氯乙烷、三氯乙烯、苯、二甲苯等用于油漆涂料、清洁溶剂等；作为汽油添加剂，DMC可提高其辛烷值和含氧量，进而提高其抗爆性。

It is possile to induce re-expression of a hypermethylated and silenced tumor suppressor gene by intervening in the DNA methylation and in histone deacetylation. It is worthful to deepen the study on the area of"transcriptional path"for prevention and cure of leukemia.

干扰DNA甲基化和组蛋白去乙酰化，以恢复抑癌基因的重新表达是可能的，通过这种&转录途径&防治白血病是值得深入探讨的研究领域。

All the derivatives were subjected to elemental analysis, FT-IR analysis, and Congo red test and their degrees of substitution were determined.

对虎奶多糖进行化学修饰，制备了多种不同取代度的羧甲基化和硫酸酯化虎奶多糖，并分别进行了元素分析、FT-IR分析及GPC分析，测定了它们的取代度和分子量。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。