甲基化作用

Objective: To investigate the role of p16 gene aberrant methylation in the malignant progression of human bladder cancer.

目的：研究膀胱移行细胞癌中p16基因甲基化失活及其在肿瘤发生中的作用。

Objective To detect methylation in p16 gene in whole blood and bronchia rinse of lung cancer,and to explore its significance for early diagnosis in lung cancer.

目的检测肺癌患者支气管灌洗液及全DNA中p16基因甲基化，并探讨其在肺癌早期诊断中的作用。

Sodium fatty alcohlo ether sulfate, S-80, fatty alcohol-polyoxyethylene ether and S-60 resulted in slow photodecomposition of rotenone in aqueous solution revealing a photo-extinction effect, sodium dodecylberzenesulfonate, tween-60, hexadecyl trimethyl ammonium bromide and poyl vinyl pyrrolidone made the photolysis of rotenone in aqueous solution fast showing an obvious photosensitized effect.

室内条件下研究了鱼藤酮水溶液存在不同表面活性剂时，鱼藤酮的紫外光降解，结果表明：脂肪醇聚氧乙烯醚硫酸钠、司本－80、长链脂肪醇聚氧乙烯醚和司本－60对鱼藤酮在水溶液中的光解速率表现出显著的光猝灭降解效应；十二烷基苯磺酸钠、吐温－60、十六烷基三甲基溴化铵和聚乙烯吡咯烷酮对鱼藤酮在水溶液中的降解表现出一定程度的光敏化作用。

During the process of nitrosamine-induced esophageal carcinoma, up-regulation of numerous genes may associate with the demethylation of genomic DNA at the early stage.

在亚硝胺诱导食管癌变过程中，大量基因的上调表达可能与早期基因组的低甲基化密切相关， Gadd45a可能参与了诱导早期的脱甲基作用。

During the process of nitrosamine-induced esophageal carcinoma, up-regulation of numerous genes may associate with the demethylation of genomic DNA at the early stage. Gadd45a may be involved in the demethylation during the early weeks.

在亚硝胺诱导食管癌变过程中，大量基因的上调表达可能与早期基因组的低甲基化密切相关，Gadd45a可能参与了诱导早期的脱甲基作用。

Gel-type cross-linked polystyrene-isocyanuric acid resin has been obtained by reaction of chloromethylated polystyrene with isocyanuric acid under the existence of triethylamine.

由氯甲基化低交联聚苯乙烯和异氰尿酸在三乙胺作用下反应，制得了凝胶型交联聚苯乙烯-异氰尿酸树脂，测定了该树脂对苯酚和间苯二酚在不同温度下的吸附等温线，依据Clapeyron-Clausius方程从吸附等温线计算出了吸附热，从热力学的角度论证了树脂是基于氢键键合和疏水作用而吸附苯酚和间苯二酚的。

Taken together, these results indicate that Hypb is required for embryonic vascular remodeling and provide a tool to study the function of H3K36 methylation in vasculogenesis/angiogenesis.

我们的这项研究结果证明HYPB基因在血管发育中具有重要作用，并为下一步研究H3K36三甲基化修饰在血管发育中的作用机制提供了一个良好的模型。

Objective: Design and synthesize the oligodeoxynucleotides containing unm- ethylated CpG dinucleotides to screen out the optimal CpG-ODN that could markedly enhance the immune function of cord blood mononuclear cells in health newborns. Moreover, observe the action of CpG-1826 (5'-TCCATGACGTTC CTGACGTT-3') as the immune adjuvant of the hepatitis B vaccine on the pregnant mice and their neonatal mice.

目的：设计并合成含非甲基化胞嘧啶和鸟嘌呤二核苷酸的寡聚脱氧核糖核苷酸，以期筛选出对新生儿脐血单个核细胞免疫刺激作用较强的CpG-ODN；观察不同剂量CPG-1826(5'-TCCATGACGTTCCTGACGTT-3')辅助乙肝疫苗免疫孕鼠及仔鼠的作用。

The specific inhibitor of DNA methylation that is available currently is 5-Aza-2'-deoxycytidine (5Aza-dc), which forms a covalent bond with the DNA methyltransferase, thus, limiting the number of free DMT molecules for methylating DNA and then decreasing its biology activity.

目前研究较多的甲基化抑制剂是胞苷类似物5-氮杂-2'-脱氧胞苷(5-Aza-2'-deoxycytidine， 5Aza-dc)。5Aza-dc的作用机制是与DNA甲基转移酶共价结合，降低酶的生物活性。

A DNA demethylating agent. This finding suggests that Met induce the flowering of detached cotyledon culture perhaps through acting as a methyl donor of DNA methylating not as the precursor of ethylene synthesis.

上述结果说明：10^(-5)M Met浸种3 h能显著促进子叶培养物的花芽形成，Met对离体子叶成花的诱导作用可能是作为甲基供体通过DNA甲基化途径来实现的。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。