甲基

New ruthenium benzylidene complexes benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene] [k~2-diphenylphosphinoacetato] monochlororuthenium (46), benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene][k~2-3-propionato]monochlororuthenium (47), benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene] [k~2-2-benzonato]monochlororuthenium (48) featured five-membered, flexible six-membered and rigidsix-membered chelating rings respectively are prepared by reactions of complex 41 withcorresponding sodium phosphino-carboxylates. It is confirmed by X-ray crystallographicanalysis that the coordination geometries of complexes 46 and 47 are distorted squarepyramids with phosphino-carboxylate ligands chelating to ruthenium, and the coordinationbetween ruthenium and benzylidene ligands are strengthened.

用二苯基瞵乙酸盐、二苯基膦丙酸盐、二苯基膦苯甲酸盐与钌卡宾配合物41反应合成了三个新的钌卡宾配合物：含五元膦-氧螯合环的1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基1-苯亚甲基--一氯合钌(46)、含六元柔性膦-氧螯合环的[1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基1-苯亚甲基--一氯合钌(47)及含六元刚性膦-氧螯合环的[1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基]-苯亚甲基--一氯合钌(48)。X射线单晶衍射分析证明，配合物46、47都为变形的四方锥构型，膦-氧与钌形成螯合配位，其中苯亚甲基与钌的配位得以加强。

Benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene]dichloro(2-methylpyridine)ruthenium (62), benzylidene[1,3-bis(2,6-dimethylphenyl)-4,5-dihydroimidazol-2-ylidene] dichloro(2,4-dimethylpyridine)ruthen ium (63) introduce ortho substituted pyridine as dissociating ligand to weaken Ru-N bondand accelerate dissociation of pyridine derivative ligand through steric hindrance.

在钌卡宾配合物[1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基]-苯亚甲基-(2-甲基吡啶)-二氯合钌(62)，1，3-二-(2，6-二甲苯基)-4，5-二氢咪唑基1-苯亚甲基-(2，4-二甲基吡啶)-二氯合钌(63)中，邻位取代的吡啶作为解离配体，通过邻位基团的空间效应削弱钌-氮配位键，使配体更易解离，提高了催化剂的初活性。

ConclusionThe main components of liposoluble components are D-Limonene,-3,7-dimethyl-1,3,6-Octatriene,-2,6-dimethyl-2,4,6-Octatriene, Caryophyllene, 2,6-dimethyl-6-(4-methyl-3-pentenyl)-Bicyclo［3.1.1］hept-2-ene, alpha-Farnesene, and-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-Tetracosahexaene.

结论蹄叶橐吾的脂溶性成分主要为D-柠檬烯（2.98%）、-3，7-二甲基-1，3，6-辛三烯（15.07%）、-2，6-二甲基-2，4，6-辛三烯（3.61%）、石竹烯（3.62%）、2，6-二甲基-6-(4-甲基-3-戊烯)-二环［3.1.1］庚-2-烯（6.20%）、α-法呢烯（4.09%）、反式角鲨烯（26.91%）等。

Chromatography peaks were obtained by GC-MS and 56 compounds were identified. The main components were linalyl butyrate (30.212%),(1α, 3α, 4β, 6α)-4,7,7-trimethyl-bicycloheptan-3-ol (10.940%),-4-carene (1.826%), 4-methylene-1-(1-methylethyl)-bicyclo [3.1.0] hexane (1.109%),β-myrcene (1.170%), limonene (5.784%), 3, 7-dimethyl-1, 6-octadien-3-ol (5.742%), n-hexadecanoic acid (0.914%) and-9, 12-octadecadienoic acid (2.952%), etc.

用GC-MS分离出69个峰，鉴定出56种物质，主要成分为：芳樟丁酸酯(30.212%)、(1α， 3α， 4β， 6α)-4，7，7-三甲基－双环[4.1.0]庚烷－3-醇(10.940%)、-4-蒈烯(1.826%)、4-亚甲基－1-（1-甲基乙基）－双环[3.1.0]环己烷(1.109%)、β-月桂烯(1.170%)、柠檬烯(5.784%)、3，7-二甲基－1，6-辛二烯－3-醇(5.742%)、n-棕榈酸(0.914%)、-9，12-十八碳烯酸(2.952%)等。

According to the result, we believed that the reason resulted in the low sensitivity was that the marker residue compound MQCA structure has changed after conjugated with protein and the antibody induced by the conjugation could not recognize the free MQCA in the ci-ELISA. Therefore we designed some hapten which could reserve the marker residue structural speciality mostly. After synthesis route selection and optimum, the hapten 7-Hydroxymethyl-3-methyl-quinoxaline-2-carboxylic acid was synthesized, used 4-methyl-2-nitroaniline as the start material via six steps, such as oxidation cyclization, bromize reaction, hydrolysis, Beirut reaction, reduction, hydrolysis. This work established basis for producing the high affinity antibody and developing the sensitive ELISA residue detection method.

本论文认为导致ELISA检测灵敏度较低的原因，是残留标示物和蛋白偶联后的特征结构发生改变，诱导产生的抗体不能够对游离MQCA很好的识别，因此，本论文设计了能够最大化保留MQCA结构特征的系列半抗原结构，并对其合成路线进行了筛选和优化，最终以对甲基邻硝基苯胺为起始原料，经氧化环化、溴代、水解、Beirut缩合、还原、水解六步反应制备含羟甲基结构的MQCA衍生物7-羟基甲基-3-甲基-喹噁啉-2-羧酸，为制备对游离残留标示物高亲和力的抗体，高灵敏度的ELISA残留检测方法的建立奠定基础。

Compounds were determined from more than 3 stages, including germacrene D, caryophyllene, phenol, 2, 6-bis (1, 1-dimethylethyl)-4-methyl-,β-elemene,γ-elemene, 1-octanol, 2-butyl-, dibutyl phthalate, cyclohexane, 1-ethenyl-1-methyl-2-(1-methylethenyl)-4(1-methylethylidene)-and butyl caprylate.

其中，3个时期以上能检测到相同的化学成分有9种，分别是大牻牛儿烯D、丁香烯、2，6-二叔丁基－4-甲基苯酚、β-榄香烯、γ-榄香烯、2-丁基－1-辛醇、邻苯二甲酸二丁酯、1-乙烯基－1-甲基－2-（1-甲基乙烯基）－4-（1-甲基亚乙烯基）环己烷和辛酸丁酯。

Their adsorption rate on the molecular sieve catalysts surface and the stability of their carbonium ions were then obtained based on the molecular simulation on these molecules from their dipole moment, 2-dimensional electrostatic potential energy contours and 3-dimensional electrostatic potential energy isosurface.

采用半经验的AM1量子化学计算方法和静态理论，分别考察了噻吩、 3 甲基噻吩和 2 ，5 二甲基噻吩分子结构特性的不同，从偶极矩、各自垂直于芳香环平面的二维电势能分布曲线和整个分子周围三维电势能分布情况等方面分析了它们在分子筛催化剂表面吸附速度的快慢和生成正碳离子稳定性的高低，进一步比较了噻吩及其衍生物所生成的正碳离子进一步反应的能量变化，从而可判断噻吩及其衍生物裂化脱硫速度的快慢，噻吩及其衍生物裂化脱硫的速度由大到小分别为：2 ，5 二甲基噻吩、 3 甲基噻吩、噻吩。

The inhibitor for DNA methyltransferase, 5-azacytidine (5-azaC), can demethylate the methylated DNA and restore transcription of genes. High dose homocystine can mediat DNA methylation and suppress gene expression.

应用甲基转移酶抑制剂5-氮杂胞苷(5-azacytidine， 5-azaC)可以使甲基化的启动子去甲基化，启动基因重新转录；高浓度同型半胱氨酸(homocystine， Hcy)可以介导基因甲基化而抑制其表达。

With benzoic acid, terephthalic acid, 2. 6naphthalene dicarboxylic acid, dimethyl-2, 6-naphthalene dicarboxylate as solutes, water, acetic acid, N, N-dimethylformamide, N, N-dimethylacemide, dimethyl sulphoxide, N-methl2-ketopyrolidine, and the mixture of water and acetic acid as solvents respectively, the solubilities of 15 binary systems and 4 ternary systems were determined.

实验以苯甲酸、对苯二甲酸、2，6-NDCA、2，6-萘二甲酸二甲酯为溶质，以水、醋酸、N，N-二甲基甲酰胺、N，N-二甲基乙酰胺、二甲基亚砜、N-甲基-2-吡咯烷酮以及水和醋酸的混合溶液为溶剂，测定了十五个二元物系和四个三元物系的溶解度数据。

In this Ph. D. dissertation, reverse microemulsion method was fully used infabricating and modifying polyacrylamide with functional and high-relative moleculeweight. The copolymerization of 2-acrylamide-2-methylpxopanesulfonic acid, fluorescent monomer 4-methoxy-N-(2-N\', N\'-dimethylamino ethyl)naphthalimide alkyl chloride quaternary ammonium salt, fluorescentmonomer 4-(N\'-methyl-1-piperazinylallyl)-N-butyl-naphthalimide chloride quaternaryammonium salt, Cationic monomer dimethylethylammonium bromide and hydrophobical monomer octadecylacrylate with acrylamide and properties of the copolymers werestudied. The interaction between five polymers and Al_2O_3(012) crystal surface have beensimulated by Materials Studio 3.0 program package, binding energies and non-bondinteraction energies and deformation energies have also been acquired.

本文以制备具有较高相对分子质量和功能型PAM为研究目的，将反相微乳液法运用到其制备及改性的有关环节，通过反相微乳液聚合工艺，将几种改性功能单体2-丙烯酰胺基-2-甲基-丙磺酸、荧光单体2-(4-甲氧基-1，8-萘二甲酰亚胺基)-乙基二甲基烯丙基氯化铵、荧光单体4-(N'-甲基-1-哌嗪基)-N-丁基-1，8-萘烯丙氯季铵盐、阳离子单体丙烯酰氧乙基-二甲基-乙基溴化铵和疏水单体丙烯酸十八酯与AM共聚，制备AMPS改性PAM、荧光示踪型PAM、阳离子单体DMB改性PAM和OA改性PAM等四类不同功能单体改性PAM，并研究其应用性能。

Now, however, all children continue in "comprehensive" schools, and the eleven-plus determines which courses of study the child will follow.

然而现在，所有的孩子都要在综合学校继续学习，所以这次考试只是决定他们将要学习哪些课程。

Cultivatable land , and led to a general recognition that development must not be carried at the cost of agriculture .

城区的迅速扩大在很多情况下侵占了宝贵的可耕地，使人们普遍认识到发展不能以牺牲农业为代价。