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The title nano-sized polymeric microgels were synthesized by emulsion polymerization method,using divinyl benzene as crosslinking agent and methyl methacrylate,hydroxyl ethyl methacrylate,butyl acrylate as monomers.

通过乳液聚合的方法,以二乙烯基苯为交联剂,用甲基丙烯酸甲酯、甲基丙烯酸-β-羟乙酯、丙烯酸丁酯等丙烯酸酯类单体合成纳米尺寸的聚合物微凝胶粒子。

Use D4 or DMC, Divinyl tetramethyl disiloxane, Tetravinyl tetramethyl cyelo tetrasiloxane were used as raw materials and Tetramethyl ammonium hydroxide as catalyst to synthesize a high molecular weight of vinyl silicone oil. Concentrate hydrosilicone oil, tetramethyl dihydro disiloxane, hexamethyldisiloxane and D4 were used to synthesize the cross linker of low-hydro silicone oil required in experiments.

以D4或DMC,乙烯基双封头,乙烯基环体等为原料,四甲基氢氧化铵为催化剂合成了不同摩尔质量的乙烯基硅油;以高含氢硅油,含氢双封头,六甲基二硅氧烷,D4合成实验所需的交联剂低含氢硅油。

The results showed that MGM had good spherical shape and narrow size distribution,and the particles with diameters ranging from 0.13 mm to 0.28 mm were about 91 wt%.The surface hydrophilicity of Fe3O4 microcrystal was improved by formamide dispersing treatment.The gel particles made by the copolymerization of glycidyl methacrylate and N,N′-methylene bisacrylamide could encapsule Fe3O4 microcrystal to produce colloid cores,and uniform and stable MGM microspheres were formed by the conglomeration of the colloid cores.

结果表明,合成的MGM呈球形,且粒度分布较窄,粒径为0.13~0.28 mm的粒子占91%;甲酰胺分散Fe3O4,微晶表面的亲水性进一步增强,单体甲基丙烯酸缩水甘油酯和 N,N′亚甲基双丙烯酰胺交联共聚生成的胶粒能够包埋Fe3O4微晶形成胶核,胶核聚集形成均匀、稳定的MGM微球。

In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11, and PML-RARA leukemia entities are associated with specific methylation profiles.

此外,根据DNA甲基化的不同可将CEBPA基因畸变与其他亚型的白血病区分开来,并定义出四个不同表型的伴NPM1基因突变的急性髓系白血病,并且表明AML1-ETO, CBFb-MYH11,和 PML-RARA 三种白血病类型与特定的甲基化有关。

Treatment of cisplatin-resistant cell lines with an inhibitor of DNA methyltransferases, 2-deoxy-5'azacytidine, results in partial reversal of DNA methylation, re-expression of epigenetically silenced genes including hMLH1 and sensitisation to cisplatin both in vitro and in vivo.

DNA甲基转移酶抑制剂2 -脱氧- 5'氮胞苷可部分逆转顺铂耐药细胞株的DNA甲基化,在体外和体内使后生沉默基因包括hMLH1基因重新表达并增加对顺铂的敏感性。

The results show that:(1) When N-methylethylenediamine and N, N'-methylethylenediamine equatorially coordinated to Cd〓, arenedisulfonates such as 1, 5-naphthalenedisulfonate, 2, 6-naphthalenedisulfonate and 4, 4'-bipenyldisulfonate act as a bridging ligands coordinated to adjacent Cd〓 centers, leading to a one dimensional chain structure.

研究结果表明:(1)N-甲基乙二胺和N,N'-二甲基乙二胺与Cd〓在赤道平面配位后,芳烃二磺酸根离子作为桥联配体与相邻的Cd〓在轴向配位形成了一维链状结构。

The expression and activity of DNA methyltransferases are downregulated in patients with lupus erythematous, which is linked with the DNA hypomethylation of T cells.

狼疮患者DNA甲基转移酶的表达与活性降低,并与T 淋巴细胞DNA 低甲基化发生机制相关。

Using pentaerythritol as initiator, boron trifluoride diethyl etherate as catalyst.dichloroethane as dispersion agent, the chloride polyether polyol is synthesized based on the mechanism of cationic ring-opening polymerization of epiclilnrohyclrin.The azide polyether polyol is synthesized, in DMF through A and sodium azide, and the non-reported azide energetic curing agent is synthesized through the adduction of B and IIDI.

以季戊四醇为起始剂,三氟化硼乙醚为催化剂,1,2—二氯乙烷为分散剂,环氧氯丙烷经阳离子开环聚合反应制成氯化聚醚多元醇,A在N,N—二甲基甲酰胺中与叠氮化钠反应制得叠氮聚醚多元醇,B与六亚甲基二异氰酸酯加成反应制得未见文献报道的叠氮固化剂。

First, the preparation of the aminom ethylation of tannin using its electrophilic reaction activity of C-6, C-8 in ring-A; then process the quaternization base on the aminom ethylation; last, progress the sulfonation by use of the activity of phenolic hydroxyl hi ring-B.

首先利用单宁A环的C—6、C—8的亲电反应活性制备单宁胺甲基化产物;然后在胺甲基化的基础上进行季胺盐化;最后利用单宁B环的酚羟基的活性进行磺化。

OBJECTIVE: To observe the biocompatibility and fibrovascular condition of methl-methacrylate modified PHEMA hydrogel orbital implant.

目的:观察通过甲基丙烯酸改性聚甲基丙烯酸β羟乙酯水凝胶义眼台的生物相容性和纤维血管化情况。

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