甲基

The carboxymethyl soybean polysaccharides had been synthesized and the mechanical strength, solubility, bacteriostasis of algin, algin carboxymethyl soybean polysaccharides alloy membrane had been studied.

用氯乙酸作为羧甲基化试剂合成了羧甲基大豆多糖；测定了羧甲基大豆多糖、褐藻胶、褐藻胶-羧甲基大豆多糖合金膜的机械强度、溶解性；并对其肠溶性、抑菌性也作了探讨。

Apparent partition coefficient in octanol-water and binding percentage to BSA of ~(153)Sm-NTMP,~(153)Sm-HEDTMP,~(153)Sm-DCTMP,~(153)Sm-EDTMP,~(153)Sm-DTPMP,~(113,117) Sn~m-EDTMP,~(113,117) Sn~m-HEDTMP,~(113,117) Sn~m-DTPMP are measured. The results show that there is a linear relationship between the relative magnitude of the apparent partition coefficient in octanol-watetr and the relative magnitude of the binding percentage to BSA of these ~(153)Sm~(113,117Sn~m complexes.

测定了NTMP，HEDTMPN (羟乙基乙二胺基三亚甲基膦酸，DCTMP(1，2 环己二胺四亚甲基膦酸)，EDTMP(乙基二胺基四亚甲基膦酸)，DTPMP(二乙基三胺基五亚甲基膦酸)的153Sm配合物以及HEDTMP，EDTMP，DTPMP的113，117Snm配合物在正辛醇水中的表观脂水分配系数和在0 5%牛血清白蛋白水溶液中与BSA的结合率。

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

Methods 4-Hydroxy- benzonitrile was treated with sodium hydrogen sulfide and anhydrous magnesium chloride in dimethyl formamide to give thioamide, which was then directly cyclized with ethyl 2-chloroacetoacetate without separation to give ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(2) in one-pot; then 2 was formylated with Duff reaction adopting hexamethylenetetramine in trifluoroacetic acid to give ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate(3); finally, the target compound was obtained by the treatment of 3 with hydroxylamine hydrochloride and sodium formate in formic acid.

采用"一勺烩"方法，以4-羟基苯甲腈为起始原料，首先与硫氢化钠和无水氯化镁在N，N-二甲基甲酰胺中反应，所得中间体不经分离，直接加入2-氯乙酰乙酸乙酯进行环合反应，得到2-(4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（2）；然后通过六亚甲基四胺/三氟乙酸进行Duff反应，得到2-(3-甲酰基-4-羟基)苯基-4-甲基-5-噻唑甲酸乙酯（3）；再经盐酸羟胺/甲酸/甲酸钠体系脱水得到目标化合物。

Dimethicone ,Cyclopentasiloxane,Dimethicone/Vinyl Dimethicone Crosspolymer,Polysilicone-11,Glycoproteins,Panax Ginseng Root Extract,Equisetum Arvense Extract,Silica Dimethyl Silylate ,Bisabolol,Tocopheryl Acetate ,Sodium Hyaluronate,Ursolic Acid,Atelocollagen,Sodium Chondroitin Sulfate,Ethylhexyl Methoxycinnamate,Polyglyceryl-2 Tetraisostearate ,Glycerin ,Water,Alcohol,Butylene Glycol ,Lecithin,Xanthan Gum ,Mica,Fragrance ,Benzyl Alcohol,Linalool ,Hydroxycitronellal,Alpha-Isomethyl Ionone ,Amyl Cinnamal,Hexyl Cinnamal,Palm Tree Extract,Geraniol,Benzyl Benzoate,Butylphenyl Methylpropional,Phenoxyethanol,Methylparaben,Isopropylparaben,Butylparaben ,Isobutyl Paraben,Titanium Dioxide,Carmine

地美司康，环戊硅氧烷，聚二甲基硅氧烷/乙烯基聚二甲硅氧烷交联聚合物，聚硅氧烷-11，糖蛋白，人参根萃取，问荆萃取，二甲基甲硅烷基化硅石，没药醇，醋酸盐维他命E，透明质酸钠，熊果酸，去端肽胶原，硫酸盐软骨素，4-甲氧基肉桂酸-2-乙基己基酯，聚甘油-2 四异硬脂酸酯，甘油，水，酒精，丁二醇，卵磷脂，山羊胶，云母，香料，苯甲醇，沉香醇，羟基香茅醛，α异甲基紫罗酮，戊基肉桂醛，己基肉桂醛，棕榈树萃取，香叶醇，苯甲酸苯甲酯，丁苯基甲基丙醛，苯氧乙醇，羟苯甲酯，羟苯丙酯，羟苯丁酯，二氧化钛，胭脂虫红

Under the above optimum conditions, other trimethylolpropane fatty acid esters, such as trimethylolpropane lauric acid ester, trimethylolpropane myristic acid ester, trimethylolpropane capric acid ester and trimethylolpropane octanoic acid ester were synthesized, and their esterification rates were 80.97%, 87.03%, 80.73% and 81.24%, respectively.

在上述的最优条件下，分别合成三羟甲基丙烷月桂酸酯、三羟甲基丙烷豆蔻酸酯、三羟甲基丙烷癸酸酯、三羟甲基丙烷辛酸酯，其酯化率分别为80.97%、87.03%、80.73%和81.24%。

Ingredients: Rose oil, rose fruit Oil, clove flower oil, deionized water, isopropyl myristate, glycerol, propylene glycol, polyethylene glycol -400, central PDMS, poly dimethyl siloxane, PDMS alcohol, polyacrylamide, C13-14 iso-paraffin, octoic acid / capric Acid Triglyceride, lauryl alcohol -7, hydroxyethyl acrylate, acryloyldimethyltaurate copolymer, squalane, poly sorbate esters -60, PEG-20 sorbitan laurate, panthenol, allantoin, methyl p-hydroxybenzoate, diazolidiny1 urea, 3-iodo-2-propynyl-butyl-carbamate, essence.

产品成分：玫瑰精油、玫瑰果油、丁香花油、去离子水、肉豆蔻酸异丙酯、甘油、丙二醇、聚乙二醇-400、环聚二甲基硅氧烷、聚二甲基硅氧烷、聚二甲基硅氧烷醇、聚丙烯酰胺、C13-14 异链烷烃、辛酸/癸酸甘油三酯、月桂醇醚-7、羟乙基丙烯酸酯、丙烯酰二甲基牛磺酸钠聚物、角鲨烷、聚山梨酸酯类-60、PEG-20 失水山梨醇月桂酸酯、泛醇、尿囊素、对羟基苯甲酸甲酯、双咪唑烷基脲、碘代丙炔基丁基甲氨酸酯、香精。

The results indicated that the total hydrodesulfurization ratio of sulfur-containing compounds of FCC gasoline was 86.3%, sulfide and tetrahydrothiophene were completely conversed, the hydrodesulfurization ratio of mercaptans was 96.6%, the hydrodesulfurization ratio of thiophene was 78.8%, the hydrodesulfurization ratio of alkyl-substituted thiophene was 85.8%, the hydrodesulfurization ratio of benzothiophene was 81.4% The conversed products of 3-methylthiophene were including little sulfur specie, isomerized sulfur specie (2-methylthiophene) and larger sulfur specie (2, 5-dimethylthiophene, 2,4-dimethylthiophene, 2,3-dimethylthiophene).

结果表明FCC汽油硫化物总脱硫率为86.3%，其中，硫醚和四氢噻吩的转化率都达到100%，硫醇硫转化率96.6%，噻吩硫转化率78.8%，烷基噻吩转化率85.8%，苯并噻吩转化率81.4%。3-甲基噻吩在OTA催化剂上的转化产物中含有小分子，异构硫化物（2-甲基噻吩），以及大分子异构硫化物（如2，5-二甲基噻吩、2，4-二甲基噻吩和2，3-二甲基噻吩）。

Bromo-5-formyl -3-methylpyrrole is an important intermediate of tolyporohin. On the base of introducing the present research and development of tolypo- rohin and pyrroles ramification at home and abroad, an emphasis was made on synthesis of 2-Bromo-5-formyl -3-methylpyrrole and the technical conditions of all steps, which was described as follows.

由于2-溴-5-甲基-3-甲基咯是合成托尼吩的重要中间体，本文在阐述了当前托尼吩及咯衍生物的国内外研究和开发的基础上，重点研究了2-溴-5-甲基-3-甲基咯的合成，并对各步反应进行了工艺研究，具体合成步骤如下：本文通过对乙乙酸乙酯的亚硝化、还原、成环，反应生成咯单环衍生物2，4-二乙氧羰基-3，5-二甲基咯。

By using Morris Maze task,The results indicated the learning and memory impairment was continuously maintained by MA-induced neurotoxity,PF_(11) significantly antagonized the learning and memory impairment by MA-induced neurotoxicity, Motor incoordination was studied by using the rotating rod method in mice,PF_(11) markedly alleviated the injury induced by MA.using HPLC-ECD,there were markedly decrease the contents of DA,DOPAC,HVA and 5-HIAA,PF_(11) markedly antagonised decrease of DA in MA-induced neurotoxicity.

在Morris水迷宫空间辨别性学习记忆实验中，甲基苯丙胺中毒小鼠找到平台的潜伏期明显延长，PF_(11)沈阳药科大学硕士学位论文中文摘要能显著缩短延长的潜伏期。转棒实验表明，甲基苯丙胺中毒小鼠运动协调性显著降低，而PF；；能桔抗小鼠运动协调性的降低。甲基苯丙胺中毒小鼠大脑内多巴胺及其代谢产物DOPAC、HVA含量明显降低，另外，5一羟色胺的代谢产物5－HIAA明显降低，而PF；；与甲基苯丙胺联合给药小鼠大脑内DA、HVA的含量显著升高。这些结果提示PF；通过影响多巴胺神经系统而桔抗甲基苯丙胺神经毒性的作用。

Now, however, all children continue in "comprehensive" schools, and the eleven-plus determines which courses of study the child will follow.

然而现在，所有的孩子都要在综合学校继续学习，所以这次考试只是决定他们将要学习哪些课程。

Cultivatable land , and led to a general recognition that development must not be carried at the cost of agriculture .

城区的迅速扩大在很多情况下侵占了宝贵的可耕地，使人们普遍认识到发展不能以牺牲农业为代价。