甲基

Methods: 2ethyl aniline was used as starting material of the synthesis and was processed by acetic anhydride acylation, strong nitric acid nitraction at low temperature, and desacyl synthesis to produce 2ethyl5nitro aniline. The product was then synthesized to 3methyl6nitro1Hindazole by using ringclosing reaction in the presence of NaNO2, and then ethylated to obtain 2,3diethyl6 nitro2Hindazole. The latter compound was then reduced by SnCl2/Hcl to get target compound 2,3diethyl6nitro2Hindazole.

以2乙基苯胺为原料经醋酐酰化、浓硝酸低温硝化及去酰基保护合成2乙基5硝基苯胺，后用亚硝酸钠关环得3甲基6硝基1H吲唑，经硫酸二甲酯甲基化得2，3二甲基6硝基2H吲唑，最后用氯化亚锡将其还原得到目标产物，通过1H NMR确定结构与目标产物一致。

Methods: 2-ethyl aniline was used as starting material of the synthesis and was processed by acetic anhydride acylation, strong nitric acid nitraction at low temperature, and desacyl synthesis to produce 2-ethyl-5-nitro aniline. The product was then synthesized to 3-methyl-6-nitro-lH-indazole by using ring-closing reaction in the presence of NaNO2, and then ethylated to obtain 2, 3-diethyl-6- nitro-2H-indazole. The latter compound was then reduced by SnC12/Hcl to get target compound 2, 3-diethyl-6-nitro-2H-indazole.

以2-乙基苯胺为原料经醋酐酰化、浓硝酸低温硝化及去酰基保护合成2-乙基－5-硝基苯胺，后用亚硝酸钠关环得3-甲基－6-硝基－1H-吲唑，经硫酸二甲酯甲基化得2，3-二甲基－6-硝基－2H-吲唑，最后用氯化亚锡将其还原得到目标产物，通过1HNMR确定结构与目标产物一致。

Although PRMT1 methylates nuclear orphan receptor HNF4,whether TR3,another orphan receptor,is methylated by PRMT1 and how the methyltransferase activity of PRMT1 is affected by nuclear receptor remain largely unknown.

虽然PRMT1可以甲基化核受体HNF4，但孤儿受体TR3能否发生甲基化以及PRMT1的甲基化酶活性是否被核受体调控等问题还不清楚。

A novel method combining a conventional free-radical solution polymerization with a chemical saponification was used to synthesize a, cu-dicarboxyl terminated oligo s with molecular weight below 1500. Here, cn-carboxyl terminated oligo s were firstly synthesized by the free-radical polymerization in THF, where 4,4'-azobis(4-cyanovaleric acid) was used as initiator, thioglycolic acid as chain transfer agent, then CTBMA were transformed into di-CTBMA via saponifying CTBMA in dioxane/H_2O/KOH solution.

利用传统自由基聚合法，在四氢呋喃溶液中自由基引发聚合甲基丙烯酸丁酯单体而得到w-羧基-甲基丙烯酸丁酯低聚物(分子量在1500左右)；利用CTBMA 末端酯基的反应特性，在二氧六环／水／KOH混合溶液中皂化CTBMA，使之转化为a ，w-羧基甲基丙烯酸丁酯低聚物；研究了溶剂的类别、反应时间等反应条件对皂化产物结构的影响；利用MALDI-TOF-MS及LSIMS对皂化各阶段产物进行了分析监测。

In this thesis, based on a recent genome-scale dataset of DNA methylation in human brain tissues, we developed a classifier for predicting methylation status of CpG islands using a Support Vector Machine. Nucleotide sequence contents, transcription factor binding sties and Alu repeats are used as features for the classification. The method achieves accuracy of ~85% on the brain data.

本文的主要工作就是基于人脑测得的DNA甲基化数据，挖掘DNA序列特征，用支持向量机的方法实现了预测CpG岛甲基化的目标，得到了85%的预测正确率，同时还验证了所选的三类特征对于CpG岛甲基化的指导作用，它们分别是DNA序列组合、转录因子结合位点TFBS和短重复序列Alu。

They are insoluble in water, ethanol, methanol, acetone, chloroform and benzene, but soluble in DMA, DMF and DMSO.

它们溶于N，N-二甲基甲酰胺、N，N-二甲基乙酰胺和二甲基亚矾等溶剂，但不溶于水、乙醇、甲醇、丙酮、氯仿和苯。

By the bio-assay directed fractionation of the volative constituents.dimethyl disulfide,allyl methyl trisulfide,allyl methyl sulfide and diallyl disulfide were found to increase the beating rate and beating amplitude in a standard medium,but the compund 2-pentanone without sulfide did not affect either of them.

从具有生物活性的挥发性提取物中分离得到的二甲基二硫、烯丙基甲基三硫、烯丙基甲基硫醚和二烯丙基二硫对培养心肌细胞心率和振幅均有不同程度的增强作用，而不含硫的2-戊酮则没有作用。

Bromo-5-formyl -3-methylpyrrole is an important intermediate of tolyporohin. On the base of introducing the present research and development of tolypo- rohin and pyrroles ramification at home and abroad, an emphasis was made on synthesis of 2-Bromo-5-formyl -3-methylpyrrole and the technical conditions of all steps, which was described as follows. Diethyl 3,5-dimethylpyrrole-2,4-dicarboxylate was made by nitrification, reduction and cycle of ethyl acetoacetate.

由于2-溴-5-甲酰基-3-甲基吡咯是合成托尼卟吩的重要中间体，本文在阐述了当前托尼卟吩及吡咯衍生物的国内外研究和开发的基础上，重点研究了2-溴-5-甲酰基-3-甲基吡咯的合成，并对各步反应进行了工艺研究，具体合成步骤如下：本文通过对乙酰乙酸乙酯的亚硝化、还原、成环，反应生成吡咯单环衍生物2，4-二乙氧羰基-3，5-二甲基吡咯。

The algicidal performances of monomer dimethyldiallylammonium chloride and a commercial algicide dodecyldimethylbenzylammonium chloride（ 1227 ） were contrasted with that of PDM.

对两种营养化的模拟水体，通过灭藻实验，研究了聚二甲基二烯丙基氯化铵系列样品的静态灭藻性能，考察了加药量、作用时间、特征黏度等因素对灭藻性能的影响规律，并与聚合物单体二甲基二烯丙基氯化铵及市售灭藻剂十二烷基二甲基苄基氯化铵（1227）的灭藻性能进行了对比。

objective: to prepare the molecularly imprinted composite membranes with propofol as template.methods: with the ultraviolet light and initiator, template molecular propofol, functional monomer methacrylate and crosslinking agent ethylenegly-coldimethacrylate formed molecularly imprinted composite membrane through polymerization on the surface of polyvinyli-dene fluoride microporous membrane.inspection of the combination of template molecule and functional monomer, characterization of the membrane surface morphology with scanning electron microscopy.results: the morphology of composite membranes was well.propofol bonded to methylacrylic acid with hydrogen bond.conclusion: the method of ultraviolet light-struck is feasible for preparation of molecularly imprinted composite membranes with propofol as template.

目的：制备异丙酚分子印迹复合膜。方法：在紫外光照和引发剂的作用下，模板分子异丙酚、功能单体甲基丙烯酸和交联剂乙二醇二甲基丙烯酸酯在聚偏氟乙烯微孔滤膜表面聚合形成分子印迹复合膜，考察模板分子和功能单体的结合特性，用扫描电镜表征膜的表面形态。结果：复合膜形态良好，异丙酚和甲基丙烯酸以氢键的方式缔合。结论：用紫外光照射法可以制得异丙酚分子印迹复合膜。

Now, however, all children continue in "comprehensive" schools, and the eleven-plus determines which courses of study the child will follow.

然而现在，所有的孩子都要在综合学校继续学习，所以这次考试只是决定他们将要学习哪些课程。

Cultivatable land , and led to a general recognition that development must not be carried at the cost of agriculture .

城区的迅速扩大在很多情况下侵占了宝贵的可耕地，使人们普遍认识到发展不能以牺牲农业为代价。