生血的

I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and what not; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水；我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏；我爱撒出的热呼呼的尿和久治不愈的淋病；我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像；我爱亚马逊河和奥里诺科河这样的大河，那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说，淹死在瞎眼的河口中；我爱流动的一切，甚至爱女人来月经时流出的血，它冲走了生育能力不强的精子；我爱会流动的手稿，不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的；我爱流动的一切，一切其中有时间的和适当的东西，它们把我们带回永远不会结束的开始中，即先知们激烈、令人狂喜的猥亵，宗教狂的智慧，牧师和他的橡皮连祷文，妓女的下流话，从排水道里漂走的唾液，***里的奶汁和子宫里流出的带苦味的蜜水，以及一切流质的、溶化的、放荡的和有溶解力的，所有在流动中得到静化的脓和脏物，那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and what not; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水；我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏；我爱撒出的热呼呼的尿和久治不愈的淋病；我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像；我爱亚马逊河和奥里诺科河这样的大河，那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说，淹死在瞎眼的河口中；我爱流动的一切，甚至爱女人来月经时流出的血，它冲走了生育能力不强的精子；我爱会流动的手稿，不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的；我爱流动的一切，一切其中有时间的和适当的东西，它们把我们带回永远不会结束的开始中，即先知们激烈、令人狂喜的猥亵，宗教狂的智慧，牧师和他的橡皮连祷文，妓女的下流话，从排水道里漂走的唾液，乳房里的奶汁和子宫里流出的带苦味的蜜水，以及一切流质的、溶化的、放荡的和有溶解力的，所有在流动中得到静化的脓和脏物，那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

I love the amniotic fluid when it spills out of the bag. I love the kidney with its painful gallstones, its gravel and whatnot; I love the urine that pours out scalding and the clap that runs endlessly; I love the words of hysterics and the sentences that flow on like dysentery and mirror all the sick images of the soul; I love the great rivers like the Amazon and the Orinoco, where crazy men like Moravagine float on through dream and legend in an open boat and drown in the blind mouths of the river. I love everything that flows, even the menstrual flow that carries away the seed unfecund. I love scripts that flow, be they hieratic, esoteric, perverse, polymorph, or unilateral. I love everything that flows, everything that has time in it and becoming, that brings us back to the beginning where there is never end: the violence of the prophets, the obscenity that is ecstasy, the wisdom of the fanatic, the priest with his rubber litany, the foul words of the whore, the spittle that floats away in the gutter, the milk of the breast and the bitter honey that pours from the womb, all that is fluid, melting, dissolute and dissolvent, all the pus and dirt that in flowing is purified, that loses its sense of origin, that makes the great circuit toward death and dissolution.

我爱从羊膜中溅出的羊水；我爱生着引起痛苦的的结石、肾砂和诸如此类东西的肾脏；我爱撒出的热呼呼的尿和久治不愈的淋病；我爱歇斯底里的疯话、像拉痢疾一样一泻而出的句子和灵魂全部病态的映像；我爱亚马逊河和奥里诺科河这样的大河，那儿摩拉瓦基乃之流的狂人在一只无顶的小船上漂过了梦和古老的传说，淹死在瞎眼的河口中；我爱流动的一切，甚至爱女人来月经时流出的血，它冲走了生育能力不强的精子；我爱会流动的手稿，不论它们是用象形文字写的、深奥的、反常的、多形体的或是单边音的；我爱流动的一切，一切其中有时间的和适当的东西，它们把我们带回永远不会结束的开始中，即先知们激烈、令人狂喜的猥亵，宗教狂的智慧，牧师和他的橡皮连祷文，妓女的下流话，从排水道里漂走的唾液，***里的奶汁和子宫里流出的带苦味的蜜水，以及一切流质的、溶化的、放荡的和有溶解力的，所有在流动中得到静化的脓和脏物，那些失去其出身意识的东西和那些将大循环驱向死亡和瓦解的东西。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。