生癌的

Clinical manifestations are soreness on epigastric region, decreased appetite, distention after meal and eructation. It belongs to "epigastric pain" and "Stomach Pi syndrome" in TCM with characteristics of repetition and pertinacity. In 1978, WHO listed chronic atrophic gastritis as precancerous lesions of gastric cancer because its complications of intestinal metaplasia and dysplasia are closely related to gastric cancer. This has been a research focus in clinical practice and pathology for years.

临床主要表现为上腹隐痛、食欲减退、食后饱胀、嗳气等，属中医学"胃脘痛"、"胃痞"等范畴，具有反覆发作、迁延难愈的特性。1978年WHO将慢性萎缩性胃炎列为胃癌的癌前状态，而在其基础上伴发的肠上皮化生(Intestinal metaplasia，IM)和域异型增生(DYSplasia， DYS)，则与胃癌的发生关系密切，被视为癌前病变(Precacerous lesions Of gastric cancer， PLGC)多年来始终是临床及病理学研究的重点。

As the old man has cancer in his lunge , his days are numbered .

由于肺部生癌，这老人的寿命不长了。

Purpose To investigate the clinical pathologic characteristics of adenocarcinoma with spindle cell metaplasia of the breast.

目的 探讨乳腺伴梭形细胞化生腺癌的临床病理特点及鉴别诊断要点。

Part I Role of glycogen synthase kinase 3 in squamous differentiation induced by cigarette smoke in porcine airway epithelial cell Squamous differentiation of airway epithelium induced by diverse stimuli, such as cigarette smoke, has been thought to be an adaptive response to chronic injury as well as a precancerous lesion of lung squamous carcinoma.

第一部分糖原合成酶激酶3在吸烟诱导的猪气道上皮细胞鳞状分化中的作用研究气道上皮的鳞状细胞化生常见于慢性支气管炎症、致癌剂刺激等，一般被认为是对慢性损伤的一种适应性反应，也是肺鳞癌的癌前病变，其分子机制尚未完全阐明。

Compared with control,①the mean tumor weight of H22 of SXKA Granules three dose groups were decreased significantly(P.01,P.05),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 30%;②the mean tumor weight of S180 of SXKA Granules three dose groups were decreased significantly(P.01),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 32%;③the mean tumor weight of EAC of SXKA Granules three dose groups were decreased significantly ( P.01, P.05),and the mean inhibition rates of SXKA Granules 20 g/kg dose groups were above 38%;④the mean tumor weight of Lewis carcinoma of SXKA Granules three dose groups were decreased significantly(P.01, P.05),and the mean inhibition rates of SXKA Granules 20、10、5 g/kg dose groups were above 36%;⑤the mean tumor weight of W256 of SXKA Granules three dose groups were decreased significantly ( P.01, P.05),and the mean inhibition rates of SXKA Granules 20、10 g/kg dose groups were above 32%;⑵Compared with control,SXKA Granules 20、10 g/kg dose groups had extended the survial time of the P388-bearing mice respectively(P.01),and the mean prolong rates of SXKA Granules 20、10 g/kg dose groups were above 50%;⑶Compared with S180-bearing group, SXKA Granules 20、10 g/kg dose groups could increase the weight of thymus and spleen, Spleen index and thymus index were increased, SXKA Granules 5 g/kg dose group could increase thymus index(P.05);⑷As Compared with control group, SXKA Granules 20、10 g/kg dose groups could improve mouse serum half hemolysis value depressed by transplanted tumor dramatically(P.01), which revealed the SXKA granules could improve the mouse humoral immunity system;⑸SXKA Granules 20 g/kg dose group could increase of englobe indexαon S180-bearing mice remarkably(P.01), which indicated the SXKA Granules could improve their cellular immunity system.

对荷W256大鼠，生兴克癌冲剂20、10、5 g / kg三组的平均瘤重明显低于对照组(P.01，P.05)，生兴克癌冲剂20、10 g / kg组的平均肿瘤抑制率均大于32 %；⑵与空白对照组相比，生兴克癌冲剂20、10 g/ kg能显著地延长移植小鼠白血病P388小鼠的存活天数(P.01)，生兴克癌冲剂20、10 g/ kg对荷白血病P388小鼠生命延长率均在50%以上；⑶与S180荷瘤组相比，生兴克癌冲剂对荷瘤鼠的免疫器官重量、胸腺指数和脾指数有一定的提高趋势，其中生兴克癌冲剂5 g / kg组对荷瘤小鼠的胸腺指数有一定的提高作用(P.05)；⑷与S180荷瘤组相比，生兴克癌冲剂20、10 g /kg组可提高由荷瘤引起的小鼠血清半数溶血素值的降低(P.01)，表明其可提高荷瘤小鼠体液免疫功能；⑸与对照组相比，生兴克癌冲剂20 g /kg组可提高荷S180肉瘤小鼠的免疫吞噬系数α值(P.01)，表明其可提高荷瘤小鼠细胞免疫功能。

Fourteen pathologic conditions were diagnosed with a biopsy: 4 nasopharyngeal carcinomas (0.2%), 1 hypopharyngeal carcinoma (0.05%), 2 metastatic carcinomas of the hypopharynx (0.1%), 1 vocal cord dysplasia (0.05%), 1 interarytenoid leukoplakia (0.05%), 4 cases of lymphoid hyperplasia (0.2%; 1 in the epiglottis, 3 in the nasopharynx), and 1 pharyngitis (0.05%).

有14例经由切片证实的病理诊断：4个鼻咽癌（0.2%），1个下咽癌（0.05%），2个下咽转移癌（0.1%），1个声带异生（0.05%），1个杓状软骨间白斑（0.05%），4个类淋巴增生（0.2%﹔1个在上会厌，3个在鼻咽），及1个咽炎（0.05%）。

Methods MSI was examined in 38 surgically resected GC specimens and 22 corresponding paratumor intestinal metaplasis samples using PCR, PCr-denatured polyacrylamide gel based methods.

采用PCR、PCR一变性聚丙烯酰凝胶及银染法检测38例胃癌及相应的22例癌旁肠化生组织的MSI。

Barrett's esophagus, the most important risk factor in the deelopment of adenocarcinoma of the esophagus, is a metaplastic condition in which the normal squamous epithelium of the esophagus is replaced by columnar or glandular epithelium.

Barrett食管，是食管的正常的鳞状上皮被柱状或腺状上皮所取代的一种化生状态，为食管腺癌的发生中的最重要的危险因素。

Clear cell carcinomas that may occur in the lower urinary tract include variants of the more common cancers such as prostatic adenocarcinoma and transitional cell carcinoma as well as infrequent carcinomas such as clear cell carcinoma, which is similar to that of mullerian origin and metastatic renal cell carcinoma.8 A benign process that occasionally has been reported to show marked clear cell change is nephrogenic adenoma, a lesion that is considered a benign metaplastic process.3,5,12 Perhaps because of the great histo

透明细胞癌可能发生在较低泌尿系统包括变异更常见的癌症如前列腺腺癌和过渡细胞癌以及罕见的癌如透明细胞癌，它是相似的苗勒管起源和转移性肾细胞癌 18亿美元的良性碾压工艺，偶尔被报告显示标记为透明细胞变化腺瘤，被视为是一种良性病变的化生 process.3，5，12也许因为伟大的历史

In the recent 20 years, the morbility of esophageal adenocarcinoma raised markedly in western countries. The reason of these histological changes was correlated with the increasing incidence of gastroesophageal reflux and esophageal Barrett metaplasia which was caused by the former.

近 20年来，西方国家食管腺癌的发病率明显上升，这种组织学变化的原因，可能与其患胃食管反流的发生率升高，以及由之产生的食管的 Barrett 化生有关。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。