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The main results are: construction of Tarim desert highway shelter-forest promoted soil microbial development, and with increase of plantation time of the shelter-forest, the quantity, fatty acid diversity index of soil microbe and diversity index of bacterial DNA segment enhanced notably. As to soil microbial community structure, bacteria are dominant population with amounting for over 80% of total soil microbe, and fungi is not more than 1% of total soil microbe, but soil microbial community structure was different among three soil layers. The conclusions from study methods of conventional culture, biological marker and molecule biology were almost identical, which illuminates that construction of Tarim desert highway made soil microbial activity enhance and so promote nutrient cycle and utilization of Tarim desert highway shelter-forest land.

结果表明,塔里木沙漠公路防护林的建设促进了风沙土土壤微生物的发育,随着防护林定植年限的增加,土壤微生物数量、脂肪酸和细菌DNA片段的多样性指数明显增大;土壤微生物区系组成中,细菌是优势类群,占微生物总数80%以上,而真菌很少,不到微生物总数1%,但在不同土层间有所差异;传统培养法与现代生物标记和分子生物学方法对塔里木沙漠公路防护林地土壤微生物多样性的研究结果基本一致,说明塔里木沙漠公路防护林的建设使林地土壤生物活性有所增强,有利于林地土壤养分循环与利用。

Exploratory study was made on the Guanting reservoir influent treatment by using two-stage BAF at extreme low temperature.The results show that the removal of organics and ammonia nitrogen is seriously inhibited due to low temperature,and the conversion of nitrite into nitrate is no longer a limiting factor of complete nitrification.One possible hypothesis is that the activity of nitrobacter is hi gher than that of nitrosomonas at extreme low temperature.

摘 要:两级曝气生物滤池在极低温度下(1℃以下)处理官厅水库入库水的探索性研究试验结果表明,有机物和氨氮的去除受到了低温的严重抑制,亚硝酸盐转化成硝酸盐不再是完全硝化反应的限制步骤,这可能是在极低温度条件下硝酸菌的活性高于亚硝酸菌活性的缘故。

They are classified into three basic structural types according to the arrangement of the C-9/C-10 skeleton to form the Corynanthe, Aspidosperma and Iboga types, typified by ajmalicine, vindoline and catharanthine, respectively.

单萜吲哚生物碱因其骨架和官能团的丰富变化,加上它们的生物活性,多年来一直哟引着一代又一代的化学家对其进行结构和合成研究,它们的共同生物合成前体strictosidine是由色胺和单萜苷secologanin缩合形成的。

This paper focuses on the stability study of Rhizopus oryzae IFO4697 when used for the methanolysis of renewable oils for biodiesel production. The results showed that water content was important for achieving high catalytic activity and good stability of the biocatalyst. The optimum water content was found to be 5%-15%. Both particle size and desiccation methods showed no obvious effect on the stability of the biocatalyst. With GA cross-linking pretreatment, the stability of the biocatalyst could be improved significantly. When Rhizopus oryzae IFO4697 repeatedly used for next batch reaction, direct vacuum filtration was found to be a good way for the maintenance of good stability of the biocatalyst.

本实验对固定化全细胞Rhizopus oryzae IFO4697催化植物油脂合成生物柴油的稳定性进行了系统地研究,结果表明:反应体系水含量对于全细胞催化剂的反应活性和催化稳定性有重要影响, 5%~15%含水量适宜;研究范围内,载体粒度及干燥方式对稳定性影响不显著;经过戊二醛交联后,全细胞催化油脂甲醇解反应的稳定性显著提高, 1200 h反应后,仍然可以保持75%的生物柴油得率;真空抽滤直接回用的方式有利于稳定性的保持。

Tetra-O-benzyl-D-glucose reacted with bromine to give glucosylbromide. It reacted with hydroxyl phenyl acetonitrile or hydroxyl benzaldehyde to give substituted ph- enylacetonitrile or substituted benzaldehyde.11 New stilbenes were synthesized possessing 2,3,4,6-tetra-O-benzyl-D-glucoside by condensation reaction with pheny lacetonitrile or benzaldehyde, which had potential biological activity and would be sieved in the future.

由2,3,4,6-四芐氧基葡萄糖作为中间体,首先制备出的溴代糖和含有羟基的苯甲醛和苯乙反应制备出含有糖的取代苯甲醛和取代苯乙,再和简单的苯乙或苯甲醛缩合反应生成11种具有潜在的生物活性且含有2,3,4,6-四芐氧基葡萄糖的类化合物,这些新化合物有待于进一步进行药理活性筛选。

Among them, pyrazole and its derivatives play an important part, exhibit better bioactivity and are becoming one kind of the most important leading structures in the fields of the organic synthesis.

在这些化合物中,吡唑类的化合物,尤其是吡唑类的芳环化合物被发现有着广泛的生物活性,因此成为了重要的药物研究先导结构,在很多有机合成及生物代谢过程中起着承上启下的中间体作用。

These findings suggest that NC (13-17) may play important roles in pain modulation at supraspinal level in mice and elicits these effects through a novel mechanism independent of the NC receptor and the traditional opioid receptors The bioactivity study of NC related peptide-NST showed that: NST could dose-dependently reverse the effects of NC in antagonizing EMs-induced analgesia; NST itself could increase the MAP and HVBR of rat, and the tension of rabbit isolated aorta muscle strips.

对孤啡肽相关肽—NST的生理活性研究发现,NST可以剂量依赖的拮抗NC对抗内吗啡肽-1和内吗啡肽-2的镇痛作用;NST对NC的降低大鼠平均动脉压作用无显著影响,但其本身可以升高大鼠的平均动脉压,后肢灌流压和离体血管条的张力,在心血管系统方面是一个新的生物活性肽。

Itamin D from the skin and diet is metabolized in the lier to 25-hydroxyitamin D (Figure 1), which is used to determine a patient's itamin D status1,2,3,4; 25-hydroxyitamin D is metabolized in the kidneys by the enzyme 25-hydroxyitamin D-1-hydroxylase (CYP27B1) to its actie form, 1,25-dihydroxyitamin D.1,2,3,4 The renal production of 1,25-dihydroxyitamin D is tightly regulated by plasma parathyroid hormone leels and serum calcium and phosphorus leels.1,2,3,4 Fibroblast growth factor 23, secreted from the bone, causes the sodium–phosphate cotransporter to be internalized by the cells of the kidney and small intestine and also suppresses 1,25-dihydroxyitamin D synthesis.5 The efficiency of the absorption of renal calcium and of intestinal calcium and phosphorus is increased in the presence of 1,25-dihydroxyitamin D (Figure 1).2,3,6 It also induces the expression of the enzyme 25-hydroxyitamin D-24-hydroxylase (CYP24), which catabolizes both 25-hydroxyitamin D and 1,25-dihydroxyitamin D into biologically inactie, water-soluble calcitroic acid.2,3,4

从皮肤和食物来的维生素D在肝中代谢为25-羟基维生素D(图1),被用来决定病人体内维生素D情况的1,2,3,4;25-羟基维生素D在肾中被25-羟基维生素D1羟化酶(CYP27B1)转变为有活性的1,25-二羟基维生素D 。1,2,3,4由肾产生1,25-二羟基维生素D是被血浆甲状旁腺激素和血清钙,磷水平紧密调节。1,2,3,4由骨分泌的成纤维细胞生长因子23使钠磷协同转运蛋白被肾和小肠细胞内化及抑制1,25-二羟维生素D合成。5 在1,25-二羟基维生素D作用下肾和小肠吸收钙及磷的效率增高(图1)。2,3,6 它也包括25-羟四- 24 -羟化酶的表达(CYP24),且将1,25二羟基维生素D和25羟基维生素D异化成无生物活性,水溶性的维生素D3-23羧酸。2,3,4

The compositions of complexes were determined as, by chemical and elemental analyses, Mn2CI2, Mn2Cl2, Cu2Cl2-2H2O, Cu(NO3)2-H2O, Cu(CH3COO)2, Zn2Cl2, Zn2(NO3)2-4H2O,ZnSO4 and Zn4(NO3)2, respectively. These complexes were characterized by IR,'H NMR and XPS. The crystal structures of these complexes were determined by single crystal X-ray diffraction techniques. The thermstability of the complexes was investigated by TG-DTG and the processes of their thermal decomposition were speculated. The constant-volume combustion energies of complexes, cU, were determined by a precision rotating bomb calorimeter at 298.15 K. Their standard enthalpies of formation, Hm, were calculated respectively. Finally, their biological activity was researched after the bactericidal activity was determined by selection of 1-2 bacteria.

通过化学分析、元素分析确定化合物分子组成分别为Mn_2Cl_2,Mn_2Cl_2,Cu_2Cl_2·2H_2O,Cu(NO_3)_2·H_2O,Cu(CH_3COO)_2,Zn_2Cl_2,Zn_2(NO_3)_2·4H_2O,ZnSO_4和Zn_4(NO_3)_2;借助IR、~1H NMR和XPS对化合物的键型特征进行了表征,运用X-射线单晶衍射分析法测定了个别化合物的晶体结构;以TG-DTG技术研究了化合物的热稳定性,阐明了它们的热分解机理;用精密转动弹热量计测定了化合物在298.15 K的恒容燃烧能,并计算了它们的标准燃烧焓和标准生成焓;选取1~2种病菌,初步测定了化合物的杀菌活性,进而研究了它们的生物活性。

In this paper, four new and 15 known compounds were isolated from the fermentation of two endophytes and a marine fungus, two of which were shown to be strong bioactive against the growth of Helicobacter pylori, one of which were found to be significantly potential vasorelaxation agents, and three of which were exhibited strong antifungal bioactivities.

本论文对两株植物内生真菌和一株海洋真菌的次生代谢产物的结构和生物活性进行了研究,一共得到了23个化合物,鉴定了其中19个化合物的结构,其中4个是首次发现的新化合物,从中筛选出2个具有强活性的体外抗幽门螺旋杆菌化合物和1个具有显著体外舒血管作用的物质,并发现了3个具有较强抗菌作用的化合物。

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