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To further testify the high efficiency of these new reagents in the synthesis of sterically hindered peptides, we successfully synthesized the extensively -N-methylated peptide moiety of the antineoplastic and lipophilic depsipeptide Dolastatin 15 using reagent BEP and FEP. We also synthesized the highly hindered tetrapeptide segment of Cyclosporin A using reagent BEMT and BEP, respectively.

为进一步检验这类吡啶正离子型缩合剂在有空间位阻的多肽合成中的性能,我们以BEP和FEP为缩合剂,成功地合成了具有抗肿瘤活性的亲脂性酯肽Dolastatin 15分子中高N-烷基化的肽链部分;分别以BEMT和BEP为缩合剂合成了生物活性肽Cyclosporin A中空间位阻最大的四肽片断。

The antibody was chemically conjugated onto the microspheres through the reaction between primary amino groups and the succinimide ester groups due to their high reactivity.

而琥珀酰亚胺酯基由于其与生物分子上的伯氨基具有高反应活性,条件温和,反应速度快,是一种很好的固定生物分子的功能基。

The first chapter focuses on study of theestablishment of acetylcholesterase's inhibitor's screening model and the algal fractions'inhibitory activity to acetylcholesterase. The second chapter focuses on study of chemicalconstituents of red alga Plocamium telfairia. The third chapter is a brief review aboutresearches on bioactive constituents of seaweeds.

第一章详述了乙酰胆碱酯酶抑制剂筛选模型的建立及海藻组分对乙酰胆碱酯酶抑制活性的研究,第二章详述了红藻海头红化学成分的研究,第三章对海藻生物活性成分研究概况进行了简要的综述。

The biological activity of two immunologically similar recombinant grass carp growth hormone were compared with recombinant tuna Thunnus thynnus growth hormone, as well as an analog of LHRH(D—Ala~6, Pro~9—N—Etylamide—LHRH, LHRH—A).

本文对两种具有相似免疫活性的草鱼基因重组生长激素(r—gGH—Ⅰ、r—gGH—Ⅱ)的生物活性进行了初步研究,并把它们对草鱼鱼种生长的促进能力与金枪鱼基因重组生长激素的一种高效类似物LHRH—A(D—Ala~6,Pro~9—N—Etylamide—LHRH)进行了比较。

The has been studied. Radix isatidis, a Chinese medicinal preparation used commonly , effectively in clinical and unclarified in active substance, was chosen as a model to be studied. Based on the concept of production quality control, considering the features of TCM itself, the process of TCM preparation, especially the heating process has been studied. The physico-chemical properties assay, chemical analysis and bioassay, also the bio-thermal activity had been applied in this study.

根据药物生产质量控制理念,结合中药的特点,本文选取临床常用、疗效确切但药效物质基础不清的板蓝根为研究载体,以中药制剂过程单元操作特别是加热过程质量控制为主要着力点和切入点,在常规理化检测和化学组分分析的基础上,引入生物活性检测,探索建立基于理化—生物关联检测的中药生产过程质量控制模式和方法,以期为中药生产中原料药、半成品和成品实现全程质量控制提供技术支持。

The experiment take the normal butyl alcohol as the dispersion medium, first comes to anchor using Biological glassthe effect in the negative pole Ti6Al4V deposition BG, then causes the hydroxy apatite to deposit in the BG coating, then passes through agglutinates obtains the contact surface union intensity better biological activity gradient ceramics coating.

实验以正丁醇为分散介质,先利用生物玻璃的抛锚效应在阴极的Ti6Al4V沉积上BG,然后使羟基磷灰石在BG的涂层上在沉积,再经烧结获得界面结合强度较好的生物活性梯度陶瓷涂层。

A part of microbial cells would autolyzed to release the intercellular alkanedegrading enzymes when they were cultured on alkane. Thus alkane could be degraded and synthesized alkane derivative with surface activity extracellularly. This surface-active agent would improve alkane emulsifying, and those unautolyzed cells could utilize the emulsified alkane sequentially.

微生物细胞在烃类基质中培养时,为了适应其疏水性环境以更好地摄取烷烃,会通过一部分细胞的自溶解体而使得胞内烃类代谢酶等释放,这样烃类在胞外被代谢生成具有表面活性的烷烃衍生物,该表面活性产物将促进烃类的乳化,使得剩余的未自溶解体的细胞可以借助生物表面活性剂而摄取降解烃类。

Based on the techniques of soybean peptides processing, this paper analyzes the possibility of producing exorphins during soybean peptides production, and dis cusses the safety of soybean peptides food.

外啡肽是一类来自人体外的具有类吗啡活性的生物活性肽,在对人体具有积极的生理作用的同时也存在着一些安全隐患。

In the present study, a gradated-combinatorial screening for antitumor -active microbial strains was carried out by the gradated combination of a 96-well plate lethality bioassay using brine shrimp and a flow cytometric bioassay using mouse tsFT210 cells.

为探索如何快速获取活性菌株的筛选模式,组合使用海虾生物致死法和tsFT2 10细胞的流式细胞术筛选模型,对从青岛前海和胶州湾潮间带海泥、动植物样品中分离的 162株海洋微生物,进行了抗肿瘤活性的分级组合筛选。

Up to now two series of compound have been synthesized and both of them show reasonable activities in bioassay in vitro .

经过大家的努力,已经有两类设计出来的化合物进行了有机合成。它们在初步的体外生物活性测定实验中都显示出了良好的抑制活性,有望成为先导化合物。

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。

There is no differences of cell proliferation vitality between labeled and unlabeled NSCs.

双标记神经干细胞的增殖、分化活力与未标记神经干细胞相比无改变。