生物活性的

BACKGROUND: Muscle-derived stem cells have some problems in purification, amplification and directional differentiation during in vitro culture. Basic fibroblast growth factor as a membrane of bioactive factor has been paid great attention, due to its biological activity.

背景：肌源性干细胞在体外培养过程中存在纯化、扩增、定向分化等难题，碱性成纤维细胞生长因子作为生物活性因子的一员，因其生物活性的多效性而备受关注。

The research and development of marine fungus's biological activity metabolite have the vital and practical significance.

具有生物活性的海洋真菌代谢产物被用于开发现代农药中，研究和开发海洋真菌的生物活性代谢产物具有重要的实际意义。

There was no obvious correlation between relative lipophilicity and activity in the current study. Na2Fl showed obvious synergetic action to other xanthene derivatives; it also show obvious synergetic action as combined lipophilic xanthene chemical and hydrophilic xanthene chemical.

由物化性质和生物活性的测试结果可知：光敏生物活性的测试与单线态氧的测试结果保持了高度的一致性，用单线态氧的产率这个指标来评价对微生物的光敏活性比用亲脂亲水性指标更为有效。

Thus, the photosensitizers are expected to degrade more rapidly in the environment.5. Na2Fl shows no obvious algaecidal activity with or without illumination, however, the other five xanthene derivatives shows approximately similar inherent toxicity and phototoxicity.

实验证实，呫吨类化合物在自然条件下能在发挥光敏生物活性的同时迅速降解为小分子化合物，残留量少，同时，其降解中间产物和终产物的光敏生物活性也迅速降低，对环境的潜在风险很小。5。

The rules of photo bioactivities are: Without illumination, the tested xanthene derivatives showed almost the same level of inherent toxicity to the same organism, which showed the inherent toxicity of xanthene derivatives were primarily dependent on the structure of parent molecule. Upon illumination, the photosensitizers showed obvious phototoxicity to all organisms. The xanthene derivatives showed stronger phototoxicity to Gram-positive bacteria. With the increasing number of halogen substituents, the singlet oxygen yields increased and the phototoxic activity increased too.

呫吨类化合物的生物活性的变化规律为：未经光照的条件下，呫吨类化合物的对同种待测微生物的固有生物活性基本相同，说明固有毒性可能主要决定于化合物分子的母核结构，其卤素取代基团对其影响较小；经实验光源照射下，所测MLC值明显低于未经光照条件下的值，表明呫吨类化合物对三种微生物的光敏活性明显强于对其相应的固有活性；呫吨类化合物对革兰氏阳性菌能发挥较大的光敏活性。

Preliminary antitumor activity in vitro of the new compounds indicated that the compounds have obvious inhibitory effect on human leukaemia cell (HL-60) and human galactophore cancer cell (MDA-MB-468) in the concentration of 10-4 mol/L. This result is a basis for further study on the synthesis and biological activity of this kind of compounds.

对所合成的10个新化合物进行了抗肿瘤体外生物活性试验，初步生物活性实验结果表明，该类化合物在浓度为10-4 mol/L时对人白血病细胞株(HL-60)和人乳腺癌细胞株(MDA-MB-468)有明显的抑制作用，在浓度为10-5 mol/L时没有明显的抑制作用，这一研究结果为进一步研究此类化合物的合成、生物活性的研究奠定了基础。

Five bistin Schiff base complexes were synthesized by the reaction of bistin dichloride with Schiff base derived from amino acids and salicylaldehyde in the presence of triethylamine,and were characterized by IR,1HNMR and MS.

二烃基锡配合物的结构类型及其具有较强的抗癌活性引起了人们极大的兴趣。大量的研究表明，有机锡化合物的生物活性主要取决于烃基，但配位基团也有一定的影响[1-3]，尤其在水解、输送等过程中。某些配体对生物活性的发挥还有协同作用。

In this paper, the stable Au complexes are classified according to the coordination atoms and their characteristic structure. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationship, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexes and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征，按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果：配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大；介绍了用于检测三价金配合物与可能的生物靶分子之间的相互作用的多种物理和生物学方法，重点关注了相互作用的模式，如嵌入/静电吸引/共价结合等，并解释了三价金配合物抗肿瘤活性的原因。

In this paper, the stable Au complexes are classified according to the coordination atoms and their structural characteristics. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationships, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexe and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征，按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果：配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大；介绍了用于检测三价金配合物与可能的生物靶分子之间相互作用的多种物理和生物学方法，重点关注了相互作用的模式，如嵌入/静电吸引/共价结合等，并解释了三价金配合物抗肿瘤活性的原因。

This paper categorizes the different kinds of sulfone antifungal research, emphasizing a review of some of the bioactivity research that has been conducted and discussing the effect on bioactivity of different substituent groups. Sulfone development trends and prospects for future application of sulfone compounds is also discussed.

本文从杀菌剂方面对砜类化合物的生物活性研究进行了分类综述，重点介绍了该类化合物的一些生物活性研究方面的工作，简述了不同取代基对砜类化合物生物活性的影响，并对它的发展趋势和应用前景作了展望。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。