生物合成

Furin is also involved in many diseases such as the activation of viral glycoproteins and bacterial exotoxins and the metastasis of cancer.

中文摘要多肽或蛋白质以前体形式合成后，需要前体加工酶的剪切加工才能获得完全的生物活性。

Many functionalized fullerene derivatives have been synthesized hitherto,and have potential applications in material and medicine science.

至今，人们已经合成了大量的功能富勒烯衍生物。它们在材料科学，生物医药等方面具有巨大的潜在应用价值。

It has been tried to in- duce active hydrolytic grop to the ligands of BAT, attempting to use chemical hydrolyses instead of biological hydrolyses to find ide- al brain radiopharmaceuticals. However, because of the immense work, the shortage of funds, only the syntheses of some latents have been done in this theses, and further study is still needed.

本论方中企图通过对BAT类配体引入活泼水解基因，采用化学水解代替生物水解找到理想的脑放射性药物，但因工作量大，消耗经费等问题，本论文中只作了一些潜体的合成，有关工作，有待于进一步研究。

At the concentration of 5×10〓. To get optical active target compounds,α-aminophosphonates were prepared by the stereoselective addition of phosphates to chiral imines in the presence of catalyst 〓.

不饱和烯酸杂环衍生物的合成与生物活性研究当今农药发展主要表现为开发高效、低毒、易降解、对环境友好的绿色农药。

The advances in asymmetric reduction of prochiral ketones to chiral alcohol s with biocatalysis are reviewed.

综述了国内外利用生物催化羰基的不对称还原合成手性醇的研究情况。

Methods:The peptide sequences of human CYP1A2 were analyzed according to its bioinformatics, and synthesized on the basis of hydrophilicity, antigenicity, accessibility and flexsibility. The synthesized peptides were crosslinked with keyhole limpet hemocyanin, which was used to immunize rabbits for production of Ab.

利用生物信息学方法分析CYP1A2蛋白的序列，根据亲水性、抗原性、柔韧性及表面性等指标选择多肽序列，合成CYP1A2多肽，与载体蛋白钥孔戚血蓝素（Keyhole limpet hemocyanin， KLH）偶联，免疫日本大耳白兔制备抗CYP1A2抗体。

Methods ①Human peptides of CYP450 enzymes and their proteinic sequence were analyzed by means of bioinformatics, and certain sequences were chosen and synthesized according to four indexes (Hydrophilicity Plot, Flexible Regions, Antigenic Index and Surface Probability Plot) after homology analysis by software Blast. The synthesized peptides were conjugated to keyhole limpet hemocyanin to increase antigenicity.

①利用生物信息学方法分析CYP1A2、CYP3A4及CYP4A11蛋白的序列，利用DNAstar软件中蛋白质的亲水性结构、柔韧区、抗原指数及表面概率结构指标选择多肽序列，应用Blast软件对所选序列进行同源性分析并合成多肽，与载体蛋白钥孔戚血蓝素偶联，免疫大耳白兔制备抗CYP1A2、3A4及4A11抗体。

It was a microsomal membrane-bound hemoprotein without known physiological functions at that time and was characterized by a

细胞色素P450具有加单氧酶的作用，并能参与机体解毒、甾体激素的合成、脂肪酸代谢等重要的生理反应，并广泛分布于动物、植物和低等真核生物中。

At these nadirs, chemosynthesis—the thermal and chemical energy given off by deep-sea vents—gives life to creatures like the eelpout fish and tubeworms pictured here.

在这些最低点，化学合成---上升的热气流和化学能经由深海的排气口释放出---给生物的生命像这粘鱼类和管蠕虫图片在这里。

At these nadirs, chemosynthesis—the thermal and chemical energy given off by deep-sea vents—gives life to creatures like the eelpout fish and tubeworms pictured here.

在这些最低点，化学合成---上升的热气流和化学能量释放出经由深海的排气口---给予生命的生物如粘鱼之类和管蠕虫图片在这里。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失