生物合成

Most of these peptides are amidated at their C-terminals, which is essential for their full activities. The a-amide comes from posttranslational modification that is catalyzed by α-amidase (α-AE or PAM). The amidation reaction is a rate-limiting step in the biosynthesis of regulatory peptides.

大部分活性肽的C-端是酰胺化的，而且α-酰胺基为多肽的完全生物活性所必需；α-酰胺基来自多肽的翻译后加工，由α-酰胺化酶催化完成，是酰胺化多肽生物合成途径中的限述步骤。

The foreground of transforming biomass energy by boosting up lipid biosynthesis according to transgene and thermochemistry or biochemistry way is very considerable.

通过转基因方式增强油脂生物合成以及通过热化学和生物化学方法转化生物质能的前景是非常可观的。

NADPH is required for many biosynthetic pathways and particularly for synthesis of fatty acid and steroids.

NADPH 对许多生物合成途径都是需要的，特别是对脂肪酸和甾体的合成。

The cloning of corresponding biosynthetic gene clusters is essential for new drug discovery and yield improvement by metabolic engineering.

微生物产生众多结构和生物活性多样的次级代谢产物，其生物合成基因簇的克隆是药物创新和产量提高的必要前提。

NADPH isrequired for many biosynthetic pathways and particularly for synthesis of fatty acids and steroids.

NADPH是许多生物合成途径，特别是脂肪酸和胆固醇的合成所需要的。

When 2.0 g/L of malate was added to the fermentation medium, the metabolic flux of byproducts L-Ala and lactic acid decreased by 22.1% and 16.5%. At the same time, the metabolic channeled to EMP and glyoxyl circle decreased by 2.26% and 9.09%. However, the metabolic flux channeled to HMP increased by 2.26%.The metabolic flux channeled to the L-glutamic acid synthesis pathway increased from 73.59% to 79.92%.

在L-谷氨酸发酵中、后期添加2.0 g/L苹果酸后，合成副产物L-丙氨酸和乳酸的代谢流量明显减少，分别降低了22.1%和16.5%，EMP途径和乙醛酸循环的代谢流分别减少了2.26%和9.09%，HMP途径的代谢流增加了2.26%，而L-谷氨酸生物合成的代谢流从73.59%增长至79.92%，较未添加前提高了6.33%。

The progress on chemical synthesis and biosynthesis of levulinic acid and 5-aminolevulinic acid(5-ALA) were discussed.

基于生物质资源的利用和开发，论述了乙酰丙酸的制取、5-氨基乙酰丙酸的化学合成与生物合成，阐述了其在医药、农业等方面的应用，讨论了发展趋势和亟待解决的问题。

The metabolism of glucose and glutamine of rBHK cells were prone to energy production, and the utilization of them for biosynthesis decreased. On the other hand, rBHK increased the uptake of amino acids to compensate for the osmotically elevated external environment.

随着培养基渗透压的升高，细胞的葡萄糖和谷氨酰胺代谢明显增强，代谢过程更倾向于能量生产，用于生物合成途径的比例下降，同时更多的氨基酸用于胞内氨基酸池的积累，合成更多的胞内蛋白以弥补渗透压造成的影响。

In this paper,functions of key enzymes in the biosynthesis pathway of shikimic acid were analyzed,and the breeding of engineering bacterium by genetic improvements for high yield of shikimic acid was also discussed.

简述了莽草酸生物合成的途径，着重从基因工程角度分析了莽草酸合成过程中的关键酶及其对莽草酸产量的影响，旨在为研究和开发微生物工程菌生产莽草酸提供参考。

We synthesized and used LP533401, a small molecule inhibitor of tryptophan hydroxylase-1 (Tph-1), the initial enzyme in GDS biosynthesis.

我们合成和使用LP533401，这是一种色氨酸羟化酶-1（Tph-1）的小分子抑制剂，Tph-1是GDS的生物合成最初需要的酶。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失