生物合成

With its unique molecular structure and outstanding bio-activities, qinghaosu has been proven as a worthy subject for in-depth studies with profound influence, not only for pharmacy, but also for phytochemistry, biogenetic synthesis and organic synthetic chemistry, chemical biology, etc. A great amount of work has been done in the last 30 years, with a lot more issues to be explored. Researchers need to seize the opportunity and make more achievements.

青蒿素以其独特的分子结构和杰出的生物活性显示出它是一有深远影响的研究对象，不仅对于药学，而且对于植物化学、生源合成、有机合成化学、化学生物学等学科都是一个可以大有作为的课题。30年来国内外已做了不少工作，但是还有更多的问题有待探索，机不可失，时不再来，期待着在綻放青蒿素的故土上结出更多的果实。

Severe inflammatory reaction can in- jury the body. Thereflore, retarding synthesis of PAF, increasing catabolism of PAF or blocking the combination of PAF and its re- ceptor might be the appropriate treatment. Hitherto, antagonists of PAF have been studied extensively. More than a hundred of such antagonists have been reported, some of them having even been used in clinic and having presented an optimistical prospects, especially natural antagonists BN series and kadsurenone, which have shown sound effects in both basic and clinical experiments.

因此通过阻止PAF合成，增加PAF分解和阻止PAF与其受体结合发挥生物效应可以作为一种适宜的治疗手段，PAF受体拮抗剂研究已成为热点，天然及人工合成的PAF拮抗剂种类很多，已报道有一百种以上，有些已进入临床应用，具有较好的前景，尤其是天然拮抗剂BN系列（以BN52021为代表）及海风藤酮巳在基础及临床研究中取得了可喜成果。

The total synthese three natural compounds to explore enantioselective synthesis of flavanol: We use phloroglucin and 2, 4, 6-trihydroxyacetophone as starting materials to synthesis distenin in two ways; Resorcin was used to synthsis 2, 5-dimethoxymethoxyacetophone though 3 steps.

对黄烷醇化合物的立体选择性全合成进行了探索：以间苯三酚和2，4，6-三羟基苯乙酮为原料，尝试用两条路线对Distenin化合物进行了全合成研究；以对苯二酚为原料，经三步制得2，5-二甲氧甲氧基苯乙酮，与2，4，6-三甲氧甲氧基苯甲醛反应，经四步反应得到天然产物3，5，7，2′，5′-二五羟基黄烷关键中间体1-（2′，6′-二甲氧甲氧基苯）-3-（2"，4"，6-三甲氧甲氧基苯）丙烷-1R，2R-二醇83及其对映体84；简要介绍了EGCg类化合物的生物活性和研究概况。

Functinal complementation test showed that trehalose-6-phosphate synthase mutant (tps1△), transformed by the open reading frame of SpTPS1 gene, restored growth on the mediam supplemented with glucose as a sole carbon source. This result indicated that trehalose-6-phosphate synthase gene (SpTPS1) of Selaginella pulvinata has biologically activity and is hopful to be applied to transgeneic improvement of plant for abiotic stress tolerance.

酵母功能互补试验证明，用SpTPS1基因开放阅读框转化的海藻糖合成酶基因突变（tps1△）酵母菌株，可恢复在以葡萄糖作为唯一碳源培养基上的生长，说明垫状巻柏海藻糖-6-磷酸合成酶基因SpTPS1具有生物活性，可能应用于植物抗逆性的转基因改良。

The thesis aims at the studies on the synthesis of polyol dihydroagarofuran sesquiterpenes, the synthesis of isodaucane sesquiterpene and the biological activities of sesquiterpenes.

本论文以α--山道年为原料，对多羟基二氢沉香呋喃倍半萜的合成，Isodaucane倍半萜的合成和部分一些化合物的生物活性进行了研究。

A new, stereo-controlled method of aldehyde group synthesis is summarized, which is used to synthesize aldehyde group by introducing thiazole ring and has a wide appreciation for bio-activated compounds synthesis.

摘要本文综述了一种新型可立体控制的醛基合成方法––利用唑环引入醛基的方法以及它在具有生物活性物质合成中的应用。

The aconitic acid-acrylic acid copolymer, itaconic acid homopolymer and polyepoxysuccinic acid which were non-phosphorus scale and dispersing inhibitors were synthesized with the fermentation products citric acid, itaconic acid and maleic anhydride.

以生物发酵产品柠檬酸和衣康酸为主要原料，分别合成了无磷阻垢分散剂丙烯三羧酸－丙烯酸共聚物和衣康酸均聚物，利用马来酸酐合成了聚环氧琥珀酸。

The article is focused on the current progress on the development of the transgenic crops accumulating PHB and cyanophycin by the gene engineering approach.The challenge and prospect of transgenic plant based production of biodegradable plastic was also discussed.

本文论述了应用基因工程，培育可合成PHB和蓝藻素等多聚物农作物的技术策略及研究进展，并讨论了培育合成生物降解塑料转基因植物所面临的挑战和发展前景。

Biotinylated IGF-1 was complexed with tetravalent streptavidin and then bound to biotinylated self-assembling peptides.

首先用四价的抗生物素蛋白链菌素合成生物素化的IGF-1，然后和生物素化的自我组装的肽结合在一起。

Research activities also include synthesis and modification of biological-relevant intermediates, cofactors and their corresponding analogs, for elucidation of enzymatic mechanisms.

具体内容包括生物催化体系关键中间体和辅助因子及其类似物的化学合成和修饰；生物催化体系的重建；酶催化反应的机理和生物催化剂工程等。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失