生物动力学

Studies of the binding of metal to calmodulin and the subsequent binding of metal-calmodulin complexes to the target protein/peptide revealed that the La-content calmodulin complexes to its target exhibit similar affinity with the Ca-calmodulin complexes.However, there were substle differences in protein conformation as well as the kinetical properties between the two kinds of metal-calmodulin complexes, suggesting Ln could produce cellular effects via the Ca/calmodulin signaling systems.

稀土离子和钙调蛋白的结合以及后续和靶酶的结合，在热力学上与钙离子激活蛋白具有相同的亲合力，但在动力学性质上以及细微构象上明显不同，显示稀土离子可通过细胞钙相关信号系统产生特别的生物效应。

QUfujun, vice professor, PhD, who engages in preclinical research and clinical trials of new drugs, including pharmaceutical dosage form, quality standard, medicamentous stability, pharmacodynamics, toxicology pharmacokinetics and bioequivalence and go in for the study of experiment in molecular biology.

曲福军，博士，副教授，主要从事新药的临床前实验（药物剂型、质量标准，稳定性、药效学、毒理学等）、临床实验（药代动力学、生物等效性等）及分子生物学实验研究工作。

Musculoskeletal biomechanics ; human hand movement ; metacarpophalangeal joint ; forward dynamics ; neural control ; redundancy analysis

肌骨生物力学；人手运动；掌指关节；正向动力学；神经控制；冗余分析

Over the past two decades, there have been several approximate methods that adopt different mutation models and used for estimating nonsynonymous and synonymous substitution rates based on protein-coding sequences across species or even different evolutionary lineages.

比较基因组分析是研究生物进化关系的基本工具，非同义替换率和同义替换率的计算是研究分子进化动力学的重要内容。在过去的二十多年，基于马尔科夫链的核酸替代模型一直在不断发展。

Over the past two decades, there have been several approximate methods that adopt different mutation models and used for estimating nonsynonymous and synonymous substitution rates based on protein-coding sequences across species or even different evolutionary lineages.

近日，中国科学院北京基因组研究所基因组科学及信息重点实验室通过引入新的参数构造模型，发展了一个新的ka/ks算法，该研究成果在近期出版的 Biology Direct 杂志上发表。比较基因组分析是研究生物进化关系的基本工具，非同义替换率和同义替换率的计算是研究分子进化动力学的重要内容。

The correlation of such ultrafast process with the system temperature and property of solvents is analyzed, which is useful for the further study about the ultrafast process of DNA, protein and other biological molecules, such as intra- and intermolecular electron, proton and energy transfer and photoisomerization.

本文的主要内容是利用飞秒时间分辨荧光亏蚀光谱探测技术对液相体系中的染料大分子在不同条件下的激发态振动弛豫、取向弛豫和分子间碰撞传能等超快动力学过程进行了研究，分析得到了这些超快过程与体系温度和溶剂性质之间的关系，同时为进一步研究DNA、蛋白质等生物分子体系的电子转移、质子转移、能量传递以及光致异构化等反应过程打下了基础。

Femtosecond time-resolved studies using fluorescence depletion spectroscopy were performed on the vibrational relaxation; orientational relaxation and the intermolecular energy transfer of dye molecules in solutions under different conditions. The correlation of such ultrafast process with the system temperature and property of solvents is analyzed, which is useful for the further study about the ultrafast process of DNA, protein and other biological molecules, such as intra- and intermolecular electron, proton and energy transfer and photoisomerization.

本文的主要内容是利用飞秒时间分辨荧光亏蚀光谱探测技术对液相体系中的染料大分子在不同条件下的激发态振动弛豫、取向弛豫和分子间碰撞传能等超快动力学过程进行了研究，分析得到了这些超快过程与体系温度和溶剂性质之间的关系，同时为进一步研究DNA、蛋白质等生物分子体系的电子转移、质子转移、能量传递以及光致异构化等反应过程打下了基础。

In order to further enrich and extend the studies on functional complexes, the molecular magnetism, kinetics of catalytic hydrolysis and biological activities of bridged polynuclear complexes have been studied systematically in this dissertation.

本论文围绕桥联多核配合物的分子磁学、催化水解动力学及生物活性等前沿课题进行了较深入和系统的研究，为进一步丰富和拓宽功能配合物的研究提供了一定的理论依据和某些有用的信息。

AIM: To study the bioavailability and steady state pharmacokinetics of sustained release pseudoephedrine tablet.

目的 ：研究盐酸伪麻黄碱缓释片的相对生物利用度及稳态药物动力学。

Rhabditis sp. Is a kind of nematode frequently detected in the drinking water treated with the biological GAC process. The inactivation effect of chlorination on Rhabditis sp. And kinetic model of inactivation were studied.

以采用生物活性炭工艺制成的生活饮用水中出现频率较高的小杆线虫为研究对象，研究了氯消毒剂对小杆线虫的灭活效果和动力学模型。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。